DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and AT1G19880

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_173417.2	Gene:	AT1G19880 / 838576	AraportID:	AT1G19880	Length:	538	Species:	Arabidopsis thaliana

Alignment Length:	400	Identity:	108/400 - (27%)
Similarity:	174/400 - (43%)	Gaps:	85/400 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  4111 GGRLGVGGSDSWAI--------------PTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWG 4161
            ||.|...|:.:|.|              ||.|..|..|.::.||......||:||..||..|.||
plant    19 GGELLFCGATAWDIIGKRKGAMEGNLVSPTRLRPLVGVNIRFVATGCASFHCVALDVEGRCYTWG 83

  Fly  4162 EGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSE 4226
            ..|.|:||||:.:..|||.:|..|:...:...|.|..|:..::..|..|.:|..:||:||.|.::
plant    84 RNEKGQLGHGDMIQRDRPTVVSGLSKHKIVKAAAGRNHTVVVSDDGQSLGFGWNKYGQLGLGSAK 148

  Fly  4227 DQLRPKLVEA-----LLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSD------ 4280
            :......||:     ::.....::|||:.....|..|:..::.:.|...||:||.|..:
plant   149 NGFVSVEVESTPLPCVVSDEVTNVACGADFTVWLSSTEGASILTAGLPQYGQLGHGTDNEFNMKD 213

  Fly  4281 -GCKLPYK-------IESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRP 4337
             ..:|.|:       |.||||..:|||.||:..:||:.|:|.|||||.|.:.||||........|
plant   214 SSVRLAYEAQPRPKAIASLAGETIVKVACGTNHTVAVDKNGYVYTWGFGGYGRLGHREQKDEWAP 278

  Fly  4338 KKVAALQGKKIIS----IATGSLHCVACSDSGEVYTWG----DNDE------------------- 4375
            :::...|...::.    ::.||.:....:..|::|.||    :.|:
plant   279 RRIDVFQRNNVLPPNAILSAGSANSACTAGGGQLYMWGKIKNNGDDWMYPKPMMDLSGWNLRWMD 343

  Fly  4376 ----------------------GQLGDGT--VTAIQRPRLVAALQGKHIVKVTCGSAHTLAL-ST 4415
                                  |:||.|.  ..:...|:.|..|:|.|::.|.||..|::.: ..
plant   344 SGSMHHFVGADSSCISWGHAQYGELGYGPNGQKSSAAPKKVDMLEGMHVMGVACGFCHSMVIVDR 408

  Fly  4416 SQLSERLRPL 4425
            :.:::||..|
plant   409 TDIADRLEQL 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	12/29 (41%)
		RCC1	4154..4203	CDD:278826	19/48 (40%)
		RCC1	4206..4257	CDD:278826	14/55 (25%)
		RCC1	4260..4309	CDD:278826	19/62 (31%)
		RCC1	4312..4360	CDD:278826	15/51 (29%)
		RCC1	4364..4413	CDD:278826	18/95 (19%)
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
AT1G19880	NP_173417.2	ATS1	38..384	CDD:227511	91/345 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820