DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and Nedd4l

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	XP_036017204.1	Gene:	Nedd4l / 83814	MGIID:	1933754	Length:	1261	Species:	Mus musculus

Alignment Length:	1530	Identity:	298/1530 - (19%)
Similarity:	498/1530 - (32%)	Gaps:	502/1530 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  3518 SAGPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEMLSHISHCHGLDDF 3582
            |.|..|..|...|:|..|.|:....|.....:|.:.|: ||..:...:..:         |..|.
Mouse    50 STGEDSGLQEGVGALKRSSSMFIPQLLARVDARPTRSS-SVQISLQRKAAD---------GATDS 104

  Fly  3583 GGLLGEPEAKSLVELLKLAVCGRCGPPSTSQTIADTLISLGAGTPAVAAMLLETCITELEDLCTS 3647
            .|....||.:               ||||...:.|          ..||..:...|:..|
Mouse   105 CGPPEGPEDR---------------PPSTQADLGD----------QAAATRVSAQISSSE----- 139

  Fly  3648 RHCLGKLPKPVMQESSHPYVDNVNVTGVVRIPGAEMLRLEFDSQCSTEKRNDPLVIMDGT----G 3708
                   |.||....|.|             |.|..               ||..:::||    |
Mouse   140 -------PSPVDTPGSSP-------------PRAAW---------------DPGTLVNGTCDHHG 169

  Fly  3709 RVLAMRSGREFA-------HWAP-----EIRVLGDELRWKFSSDSSVNGWGWRFWVHAIMPAATL 3761
            :...:..|.|.|       |.|.     ::|:|      .|..|.....   |.|....:|.|:
Mouse   170 QCPHLAEGPEEATPGLRIQHRASSADVRQVRLL------PFGPDGQAEP---RRWSLQHVPDAS- 224

  Fly  3762 GESGSDRAV--LSQPSMALVMSLLD----------SRLAPRQPSVLLRLASALAACSQLGALT-T 3813
            |.||....|  |.||....:....|          .||. |.|.:.|..:::.....:.|.:: |
Mouse   225 GSSGKRCFVFQLQQPQQGALGLTGDFNFGFTGTKGDRLV-RYPRIRLERSTSYPTQPRAGRVSPT 288

  Fly  3814 AQRIWSLRKLHAVLLLEQAPRPQDPSLSTLLQPLIPELLRQYEYEEPQVRGGIHLMHSD------ 3872
            ..|                   ..|..|.....::||:.|......||..|.:..:..|
Mouse   289 EDR-------------------GTPEASPRASRVVPEIRRTNSERTPQSPGCMFKIRQDQNAGQQ 334

  Fly  3873 YFKTLAALACDMQLDAALPATSSSSSSSAAPGAISSTGD-------------------VHKWAWF 3918
            :|:.|....    .:.|......:..|...|||.:.|.|                   :.:...|
Mouse   335 HFRILVTRG----PEEAPQNQEETHKSPGHPGAGAPTRDDFLGQVDVPLSHLPTEDPTMERPYTF 395

  Fly  3919 KRYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEMLPSSSSNSNANPGCQSP---GASMLNSTTSL 3980
            |.:.:..|..:|.:      :.|   :|.|.|.| |.:......|...:..   |..:::|..|
Mouse   396 KDFLLRPRSHKSRV------KGF---LRLKMAYM-PKNGGQDEENSEQRDDMEHGWEVVDSNDS- 449

  Fly  3981 SSSTVSNVSPPPGITG--EQPD--------------LHCHAHQLESTSTLLHEDHTLFQAPHDAQ 4029
            :|.....:.|||...|  |:.|              ...|...|...|:  ..|:.:.|...:|.
Mouse   450 ASQHQEELPPPPLPPGWEEKVDNLGRTYYVNHNNRSTQWHRPSLMDVSS--ESDNNIRQINQEAA 512

  Fly  4030 LLQWLNRR-----------------PDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCE 4077
            ..::.:||                 |:.|       .||     :....:.|...|....|.|..
Mouse   513 HRRFRSRRHISEDLEPEASEGGGEGPEPW-------ETI-----SEEMNMAGDSLSLALPPPPAS 565

  Fly  4078 ALSLLRPVQLAGGEQSLFAVTPD--GKLFAT--GYGSGGRLGVGGSDSWAIPTLLGSLQHV---- 4134
            .:|...|.:|:........:|||  |:.|::  ......||     .|.::...:....|:
Mouse   566 PVSRTSPQELSEEVSRRLQITPDSNGEQFSSLIQREPSSRL-----RSCSVTDTVAEQAHLPPPS 625

  Fly  4135 ----FVKKVAVNSGGKHCLAL----TTEGEVYAWGEGEDGK-----LGHGNR-MSYDRPKLVEHL 4185
                ..:...|..|.:...::    ||.|....|.|.:|.|     :.|.|| .::.||
Mouse   626 TPTRRARSSTVTGGEESTPSVAYVHTTPGLPSGWEERKDAKGRTYYVNHNNRTTTWTRP------ 684

  Fly  4186 NGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQL-RPKLVEALLGYRAIDIAC-- 4247
                :..:|...|..:|..::.|::               |.|: ||:    .|....:.::.
Mouse   685 ----IMQLAEDGASGSATNSNNHLV---------------EPQIRRPR----SLSSPTVTLSAPL 726

  Fly  4248 -GSGDAQTLCITDD--DNVWSWGDGDYGKLGRGGSDGCKLPYKI-ESLAGLGVVKVECGSQFSVA 4308
             |:.|:.......|  .|..|.....|        :..|..:|: :|....|         :.:.
Mouse   727 EGAKDSPIRRAVKDTLSNPQSPQPSPY--------NSPKPQHKVTQSFLPPG---------WEMR 774

  Fly  4309 LTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGD- 4372
            :..:|..:             .:||                              :.:..||.|
Mouse   775 IAPNGRPF-------------FIDH------------------------------NTKTTTWEDP 796

  Fly  4373 ----------------NDEGQLGDGTVTAIQRPRLVAALQGK-----HIVKVTCGSAHT---LAL 4413
                            ||.|.|..|....|.       |.|:     |..:|.||...|   :.|
Mouse   797 RLKFPVHMRSKASLNPNDLGPLPPGWEERIH-------LDGRTFYIDHSSQVLCGENDTRESVPL 854

  Fly  4414 STSQLSERLRP-LPNPPLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGDLSLGALKD 4477
            ..|::::...| |.||.:       ..|...::|     .|.:
Mouse   855 YDSKITQWEDPRLQNPAI-------TGPAVPYSR-----EFKQ---------------------- 885

  Fly  4478 VLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPL 4542
                  |...|||         |...|....||.::|..||            ::|.:..::: :
Mouse   886 ------KYDYFRK---------KLKKPADIPNRFEMKLHRN------------NIFEESYRRI-M 922

  Fly  4543 LTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQN-----------GSVPLLINTPNG 4596
            ..:....|..|:| ::|..|...|.||...|....:..|:.|           .:..|.||..:|
Mouse   923 SVKRPDVLKARLW-IEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSG 986

  Fly  4597 RGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDL 4661
            .    .|.|            .::.|.|:|.:.|:||..|..|......|.::.:.|:.:...|:
Mouse   987 L----CNED------------HLSYFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQITLNDM 1035

  Fly  4662 TEVDRDYVAGLLCIRNMDDDPKLFTALELPF---STSSARGHEVPLSTRYTHI--SPRNRAEYVR 4721
            ..||.:|...|..|  :::||   |.|:|.|   ..:..:.::|.|....:.|  :..|:.||:.
Mouse  1036 ESVDSEYYNSLKWI--LENDP---TELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYID 1095

  Fly  4722 LALGFR-LHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYK-GFD 4784
            |.:.:| ::...:|:.|..:|.::::|:.|:.:|...||:.::||..|:.:...:..:.|| |:.
Mouse  1096 LVIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYC 1160

  Fly  4785 PSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRT-IADFRGRDFVLQVLEKNPPDHF----- 4843
            |:..::.|||:.:.....::|...|:||.|.:|:|.. .|:..|         .|.|..|
Mouse  1161 PNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYG---------SNGPQLFTIEQW 1216

  Fly  4844 -----LPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
                 ||.::|||..|.:|.|.....|.|||..|:
Mouse  1217 GSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAV 1251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	7/33 (21%)
		RCC1	4154..4203	CDD:278826	12/54 (22%)
		RCC1	4206..4257	CDD:278826	8/54 (15%)
		RCC1	4260..4309	CDD:278826	8/51 (16%)
		RCC1	4312..4360	CDD:278826	3/47 (6%)
		RCC1	4364..4413	CDD:278826	16/73 (22%)
		HECTc	4509..4880	CDD:238033	96/394 (24%)
		HECTc	4553..4878	CDD:214523	89/350 (25%)
Nedd4l	XP_036017204.1	PHA03378	<107..318	CDD:223065	58/305 (19%)
		C2	<367..420	CDD:417471	10/61 (16%)
		WW	465..491	CDD:395320	4/25 (16%)
		WW	655..684	CDD:395320	7/28 (25%)
		WW	768..798	CDD:238122	7/81 (9%)
		WW	817..867	CDD:197736	13/56 (23%)
		HECTc	928..1257	CDD:214523	90/355 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900