DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and UVR8

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_201191.1	Gene:	UVR8 / 836506	AraportID:	AT5G63860	Length:	440	Species:	Arabidopsis thaliana

Alignment Length:	421	Identity:	130/421 - (30%)
Similarity:	212/421 - (50%)	Gaps:	26/421 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly  2969 VSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFI 3033
            :|.....:.|....|:.|:   ||..:..|||.........||....:...:.:.:..|:.....
plant    20 ISAGASHSVALLSGDIVCS---WGRGEDGQLGHGDAEDRPSPTQLSALDGHQIVSVTCGADHTVA 81

  Fly  3034 VSQDG-KVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSW 3097
            .||.| :||:.|.|..||||.|.:.::..|..:..|....:|::|  .|..|.||:|::|:|.||
plant    82 YSQSGMEVYSWGWGDFGRLGHGNSSDLFTPLPIKALHGIRIKQIA--CGDSHCLAVTMEGEVQSW 144

  Fly  3098 GEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDN 3162
            |..::|:||.|:......|:.::|....:|:.||.|:.|:||::..|:||.||.|.||.||.||.
plant   145 GRNQNGQLGLGDTEDSLVPQKIQAFEGIRIKMVAAGAEHTAAVTEDGDLYGWGWGRYGNLGLGDR 209

  Fly  3163 TTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIER 3227
            |.:|.|:.||:..|.::..||||.|  .|::::..||::::|...:|:||.|..|....||::|.
plant   210 TDRLVPERVTSTGGEKMSMVACGWR--HTISVSYSGALYTYGWSKYGQLGHGDLEDHLIPHKLEA 272

  Fly  3228 LSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGA 3292
            ||...:.||..|.:.::|||..|:::.||...:.::|.|.:.....|..:.....::|:.|:.|.
plant   273 LSNSFISQISGGWRHTMALTSDGKLYGWGWNKFGQVGVGNNLDQCSPVQVRFPDDQKVVQVSCGW 337

  Fly  3293 LHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALV--IGLDAVFVNRVACGS---SHSIAWGL 3352
            .|.||||:...|:|||...:||.|.|.:.....|.::  :.:|......:...:   |...:|..
plant   338 RHTLAVTERNNVFAWGRGTNGQLGIGESVDRNFPKIIEALSVDGASGQHIESSNIDPSSGKSWVS 402

  Fly  3353 PNASSDEEKRGPVPFSSTRDPLG---GSSLG 3380
            |     .|:...||     |..|   |||.|
plant   403 P-----AERYAVVP-----DETGLTDGSSKG 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826	17/51 (33%)
		RCC1	3091..3140	CDD:278826	17/48 (35%)
		RCC1	3144..3194	CDD:278826	24/49 (49%)
		RCC1	3197..3246	CDD:278826	16/48 (33%)
		RCC1	3250..3298	CDD:278826	11/47 (23%)
		RCC1	3302..3350	CDD:278826	11/52 (21%)
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
UVR8	NP_201191.1	RCC1_2	20..46	CDD:404432	6/28 (21%)
UVR8	NP_201191.1	ATS1	36..363	CDD:227511	112/333 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3500
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820