DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and RUG3

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_974971.2	Gene:	RUG3 / 836208	AraportID:	AT5G60870	Length:	452	Species:	Arabidopsis thaliana

Alignment Length:	434	Identity:	134/434 - (30%)
Similarity:	204/434 - (47%)	Gaps:	74/434 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  4044 SWGGAST-------------------IYGWGHNHRGQL-GGLEGSRIKTPTPC--------EALS 4080
            |.|||:|                   ::.||....||| ||:|..|: .|:|.        ::.|
plant    24 SGGGANTKVPILYTSPDIDSDPVTLQLFSWGRGASGQLGGGIEEIRM-YPSPVANLLFRSDQSFS 87

  Fly  4081 LLRPVQLAGGEQSLFAV-----------TPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHV 4134
            |.:.......:.|.|.:           |.||.|:..|.|.|||||.|..:|..:|.|....:..
plant    88 LAQTPGRIDADSSSFRIGISCGLFHSGLTIDGDLWIWGKGDGGRLGFGQENSVFVPNLNPLFEEH 152

  Fly  4135 FVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDR---PKLVEHLNGMSVADIACG 4196
            .::.:|:  ||.|.:|||.:|:|:.||.|..|.|||   ..|.|   |:.|:......::.||..
plant   153 SIRCIAL--GGLHSVALTHQGDVFTWGYGGFGALGH---KVYTRELVPRRVDDSWDCKISAIATS 212

  Fly  4197 SAHSAAITASGHVLTWGK----GRYGRLGHGDSEDQ----LRPKLVEALLGYRAIDIACGSGDAQ 4253
            ..|:||||.||.:..||:    ||.| ||.|...::    ..|..|:||. .....::||.  ..
plant   213 GTHTAAITESGELYMWGREEGDGRLG-LGPGRGPNEGGGLSVPSKVKALT-VPVASVSCGG--FF 273

  Fly  4254 TLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTW 4318
            |:.:|.:..:|:||.....:||||.:.|...|..:.||.|:.:.::.||...|:|||:.|.|.:|
plant   274 TMALTKEGQLWNWGANSNYELGRGDNLGGWEPMPVPSLEGVRITQIACGGYHSLALTEEGKVLSW 338

  Fly  4319 GKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVA-------CSDSGEVYTWGDNDEG 4376
            |.|...:||..|:.:.:.|.::.||..|||:.||:|.....|       .:|.||::.||:..:.
plant   339 GHGGHGQLGSSSLRNQKVPTEIEALADKKIVFIASGGSSSAAITGWDWFLTDGGELWMWGNAKDF 403

  Fly  4377 QLGDGTVTAIQ-RPRLVAAL------QGKHIVKVTCGSAHTLAL 4413
            |||...:..|| .|..|..|      |...::.::.|::|.|.|
plant   404 QLGVPGLPEIQTTPVEVNFLTEEDECQPHKVISISIGASHALCL 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	12/29 (41%)
		RCC1	4154..4203	CDD:278826	17/51 (33%)
		RCC1	4206..4257	CDD:278826	17/58 (29%)
		RCC1	4260..4309	CDD:278826	15/48 (31%)
		RCC1	4312..4360	CDD:278826	17/47 (36%)
		RCC1	4364..4413	CDD:278826	16/55 (29%)
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
RUG3	NP_974971.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820