DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and RUG2

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_199644.2	Gene:	RUG2 / 834886	AraportID:	AT5G48330	Length:	455	Species:	Arabidopsis thaliana

Alignment Length:	442	Identity:	115/442 - (26%)
Similarity:	182/442 - (41%)	Gaps:	99/442 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  2957 GVGPGSTAGAG-----------------AVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQLGGLKG 3004
            |:...|..|.|                 ::|..|..:.|.....   .:..||.||:.|||
plant    58 GLSSSSIPGMGMDAYEPTVVSNLPSDISSISAGHYHSLAVTSSG---EIWAWGRNDEGQLG---- 115

  Fly  3005 SKVKVPTFSQTISRLRPIHIAG----GSKSLF-------IVSQDGKVYACGEGTNGRLGLGVTHN 3058
               ::...|...||..|..:.|    ..::.|       .:..||.::..|....|:||||   |
plant   116 ---RIVIDSSRDSRSEPKRVEGLENVNVQAAFASGVVSAAIGDDGSLWVWGRSKRGQLGLG---N 174

  Fly  3059 VPLPHQLP-----VLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRL 3118
            ..:..::|     :..::|||   |..|..||||||:|||||.||...||::|:     :..|
plant   175 GIIEARVPSRVENLAAEHVVK---VSLGWGHALALTVDGKVFGWGYVADGRVGN-----VGLP-- 229

  Fly  3119 VEALRAKKIRDVACGSSHSA--------------AISSQGEL-YTWGLGEYGRLGHGDNTTQLKP 3168
            :||.....|.|.:....|:|              |:|.:.:: ..|                 :|
plant   230 LEASLLDSITDGSMKGHHAAGDLNLEAAEKKVVEAMSKENDMPIAW-----------------EP 277

  Fly  3169 KLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGV 3233
            .||......:|..:||||  ..:|.|..||.:.|.|...:|:|||...:....|.:|..    ..
plant   278 CLVEETCNEKVADIACGS--DHSLILCHDGTLLSAGSNIYGQLGRSKQDLGMKPVDITE----SP 336

  Fly  3234 VQIECGAQFSLALTRAGE--VWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCL 3296
            :.|..|...|||:...||  :.:||.....:||.|..:::  |:.:.|..|.....|:.|.:|.|
plant   337 ISIAAGLGHSLAICNRGERNILSWGWNRSRQLGRGKPENL--PREVEGFDGESPASVSAGRVHSL 399

  Fly  3297 AVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHSI 3348
            .||:.|:.:.||...:|:.|.|::....:|.|:..::...:..|| |..||:
plant   400 CVTEKGEAWVWGCGKNGRLGLGSSSDEPEPMLLEDVEGCVLQAVA-GFDHSL 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826	18/55 (33%)
		RCC1	3091..3140	CDD:278826	17/62 (27%)
		RCC1	3144..3194	CDD:278826	10/50 (20%)
		RCC1	3197..3246	CDD:278826	14/48 (29%)
		RCC1	3250..3298	CDD:278826	14/49 (29%)
		RCC1	3302..3350	CDD:278826	13/47 (28%)
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
RUG2	NP_199644.2	ATS1	36..432	CDD:227511	109/421 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820