DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and AT5G42140

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001318728.1	Gene:	AT5G42140 / 834219	AraportID:	AT5G42140	Length:	1078	Species:	Arabidopsis thaliana

Alignment Length:	928	Identity:	234/928 - (25%)
Similarity:	346/928 - (37%)	Gaps:	252/928 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  3955 SSSSNSNANPGCQS---------------PGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCH 4004
            ||.:||:.   |.|               |..|...::.|...|.|::.||...:.|...|
plant   151 SSPTNSSV---CASRDFNIADSPYNSTNFPRTSRTENSVSSERSHVASDSPNMLVRGTGSD---- 208

  Fly  4005 AHQLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGH------------N 4057
            |.::..:|......|.  .||.|...|                 ..:|.||.            .
plant   209 AFRVSVSSVQSSSSHG--SAPDDCDAL-----------------GDVYIWGEVLCENVTKFGADK 254

  Fly  4058 HRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSW 4122
            :.|.||  ..|.:..|.|.|:..:|....:|.|.:....|:..|::|..|..||||||.|.....
plant   255 NIGYLG--SRSDVLIPKPLESNVVLDVHHIACGVKHAALVSRQGEVFTWGEASGGRLGHGMGKDV 317

  Fly  4123 AIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEG--EDGKLGHGNRMSYDRPKLVE-H 4184
            ..|.|:.||....:..||  .|..|..|:|..||:|.||:|  ..|.||||..:|:..||.:. .
plant   318 TGPQLIESLAATSIDFVA--CGEFHTCAVTMTGEIYTWGDGTHNAGLLGHGTDVSHWIPKRISGP 380

  Fly  4185 LNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGS 4249
            |.|:.:|.::||..|:|.||::|.:.|:|.|.:|.|||||.|....|:.||:|.|.|.|.:|||.
plant   381 LEGLQIASVSCGPWHTALITSTGQLFTFGDGTFGVLGHGDKETVFYPREVESLSGLRTIAVACGV 445

  Fly  4250 GDAQTL---CITDDDN------VWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQF 4305
            ..|..:   .:|...:      :::|||||..:||.|..:....|..:.:|......:|.||...
plant   446 WHAAAIVEVIVTHSSSSVSSGKLFTWGDGDKSRLGHGDKEPRLKPTCVSALIDHTFHRVACGHSL 510

  Fly  4306 SVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKII-----SIATGSLHCVACSDSG 4365
            :|.||.||.|||.|...:.:||:.:.|     .|:..|...|:.     .||.|:.|....:...
plant   511 TVGLTTSGKVYTMGSTVYGQLGNPNAD-----GKLPCLVEDKLTKDCVEEIACGAYHVAVLTSRN 570

  Fly  4366 EVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLAL----------------- 4413
            ||:|||....|:||.|.|...:.|.||.||:.:|:..:.|||..|.|:
plant   571 EVFTWGKGANGRLGHGDVEDRKAPTLVDALKERHVKNIACGSNFTAAICLHKWVSGTEQSQCSAC 635

  Fly  4414 -------------------------STSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILLHHF 4453
                                     |...|...|.|.|..|..
plant   636 RQAFGFTRKRHNCYNCGLVHCHSCSSKKSLKAALAPNPGKPYR---------------------- 678

  Fly  4454 SELVC-PCLAMLPISGDLSLGALKDVLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSR 4517
               || .|.:.|....:.::.:.|:|:.....|...|  :..|.:|..:.|  |..|...:|:..
plant   679 ---VCDSCHSKLSKVSEANIDSRKNVMPRLSGENKDR--LDKTEIRLAKSG--IPSNIDLIKQLD 736

  Fly  4518 NRCNGLAGIDGMKSVFGQMVQ--KLPLLTQEALAL------------------------------ 4550
            ||    |...|.|:....:|:  :.| |||...||
plant   737 NR----AARQGKKADTFSLVRTSQTP-LTQLKDALTNVADLRRGPPKPAVTPSSSRPVSPFSRRS 796

  Fly  4551 --PHRVWKVKFVGESVDDCGGGYSESIAE---MCDELQNGSVPLLINTPNGRGEAGANRD-C--- 4606
              |..|..:..      :.|.|:|.||||   ..:||.|..|..|      |.:|.:.|. |
plant   797 SPPRSVTPIPL------NVGLGFSTSIAESLKKTNELLNQEVVRL------RAQAESLRHRCEVQ 849

  Fly  4607 -FLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEV-----LRPTDLTEVD 4665
             |.:..::..|.:         .|.:|....:  ....|:.|.:.||.:|     |.|....|.:
plant   850 EFEVQKSVKKVQE---------AMSLAAEESA--KSEAAKEVIKSLTAQVKDIAALLPPGAYEAE 903

  Fly  4666 RDYVAGLL--------------CIRNMDDDPKLFTALELPFSTSSARGHEVPLSTRYTHISPRNR 4716
            ....|.||              ..|....|....|:|..|.:..:...:.:..:::    ||||.
plant   904 TTRTANLLNGFEQNGFHFTNANGQRQSRSDSMSDTSLASPLAMPARSMNGLWRNSQ----SPRNT 964

  Fly  4717 --------AEYVRLALGF 4726
                    :|.||::.||
plant   965 DASMGELLSEGVRISNGF 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	12/31 (39%)
		RCC1	4154..4203	CDD:278826	21/51 (41%)
		RCC1	4206..4257	CDD:278826	22/53 (42%)
		RCC1	4260..4309	CDD:278826	14/54 (26%)
		RCC1	4312..4360	CDD:278826	16/52 (31%)
		RCC1	4364..4413	CDD:278826	20/48 (42%)
		HECTc	4509..4880	CDD:238033	61/287 (21%)
		HECTc	4553..4878	CDD:214523	46/209 (22%)
AT5G42140	NP_001318728.1	PH_PLC_plant-like	12..124	CDD:270171
		ATS1	<282..614	CDD:227511	120/338 (36%)
		FYVE	621..689	CDD:214499	10/92 (11%)
		BRX_N	869..904	CDD:372684	8/36 (22%)
		BRX	1003..1057	CDD:369842
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3500
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820