DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and AT5G19420

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001190338.1	Gene:	AT5G19420 / 832062	AraportID:	AT5G19420	Length:	1139	Species:	Arabidopsis thaliana

Alignment Length:	912	Identity:	227/912 - (24%)
Similarity:	351/912 - (38%)	Gaps:	208/912 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  3977 TTSLSSSTVSNVSPPPGITGEQPDLHCHAHQLESTSTLLHE--DHTLFQAPHDAQLLQWLNRRPD 4039
            |.|.|..|.|..:.|...|.....||   ....|..:...|  :|....:|:::.....:::...
plant   173 TESRSDGTPSEANSPRTYTRRSSPLH---SPFSSNESFQKEGSNHLRLHSPYESPPKNGVDKAFS 234

  Fly  4040 DW---------------------ALSWGGASTIYG------------------------------ 4053
            |.                     :||.||:.|::|
plant   235 DMSLYAVPPKGFFPPGSATMSVHSLSSGGSDTLHGHMKGMGMDAFRVSLSSAISSSSHGSGHDDG 299

  Fly  4054 --------WGHN-HRGQLGG---LEGSRIK------TPTPCEALSLLRPVQLAGGEQSLFAVTPD 4100
                    ||.. ..|.|||   ..||.::      .|...|:..:|....:|.|.|....||..
plant   300 DTLGDVFMWGEGIGEGVLGGGNHRVGSSLEIKMDSLLPKALESTIVLDVQNIACGGQHAVLVTKQ 364

  Fly  4101 GKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGED 4165
            |:.|:.|..|.||||.|...:...|.|:.:|....::.||  .|..|..|:|..|::|.||:|:.
plant   365 GESFSWGEESEGRLGHGVDSNVQHPKLIDALNTTNIELVA--CGEYHSCAVTLSGDLYTWGKGDF 427

  Fly  4166 GKLGHGNRMSYDRPKLVEHL-NGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQL 4229
            |.|||||.:|:..||.|..| .|:.|:.||||..|:|.:|::|.:.|:|.|.:|.|||||.:...
plant   428 GILGHGNEVSHWVPKRVNFLMEGIHVSSIACGPYHTAVVTSAGQLFTFGDGTFGVLGHGDRKSVF 492

  Fly  4230 RPKLVEALLGYRAIDIACG------------SGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGC 4282
            .|:.|::|.|.|.:..|||            ...:.:.|  ....:::|||||..:||.|..:..
plant   493 IPREVDSLKGLRTVRAACGVWHTAAVVEVMVGSSSSSNC--SSGKLFTWGDGDKSRLGHGDKEPK 555

  Fly  4283 KLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKK 4347
            .:|..:.:|......:|.||...:||||.||.|||.|...:.:||:...|. :.|.:|.....|.
plant   556 LVPTCVAALVEPNFCQVACGHSLTVALTTSGHVYTMGSPVYGQLGNPHADG-KVPTRVDGKLHKS 619

  Fly  4348 II-SIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTL 4411
            .: .||.|:.|....:...||||||....|:||.|.......|.||.:|:.|.:..:.|||..|.
plant   620 FVEEIACGAYHVAVLTSRTEVYTWGKGSNGRLGHGDADDRNSPTLVESLKDKQVKSIACGSNFTA 684

  Fly  4412 ALS----TSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILLHHFS--ELVCPCLAMLPISGDL 4470
            |:.    .|.:.:.:......|..:...|.   ...:..|:..|..|  :.:..|:|..|..
plant   685 AVCLHKWASGMDQSMCSGCRQPFNFKRKRH---NCYNCGLVFCHSCSNKKSLKACMAPNPNK--- 743

  Fly  4471 SLGALKDVLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSV--- 4532
                     .|.:.:..|.|:.:........|.   .|:|   :.|.|:  |...||..:.:
plant   744 ---------PYRVCDRCFNKLKKAMETDPSSHS---SLSR---RESVNQ--GSDAIDRDEKLDTR 791

  Fly  4533 -FGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSV-PLLINTPN 4595
             .||       |.:.:|..|.|         .||      |.|......|..:..| |:    |:
plant   792 SDGQ-------LARFSLLEPMR---------QVD------SRSKKNKKYEFNSSRVSPI----PS 830

  Fly  4596 GRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMG--IAVRTGSPLSINLAEPVWRQLTGEVLRP 4658
            |....|:.......:||..|..:.    |...:.|  ||.|..||:|...:.|  |..|     |
plant   831 GGSHRGSLNITKSFNPTFGSSKKF----FSASVPGSRIASRATSPISRRPSPP--RSTT-----P 884

  Fly  4659 TDLTEVDRDYVAGLLCIRNMDDDPK----------LFTALELPFSTSSARGHEVPLSTRYTHI-- 4711
            |..       ::||...:.:.||.|          :....::...|..|:..||.|......:
plant   885 TPT-------LSGLTTPKIVVDDTKRSNDNLSQEVVMLRSQVENLTRKAQLQEVELERTTKQLKE 942

  Fly  4712 --------SPRNRA--EYVRLALGFRLHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGS 4766
                    |.|.:|  |.:: :|..:|.:..|::..   |.::.:..|.|:.|.:         |
plant   943 ALAIASEESARCKAAKEVIK-SLTAQLKDMAERLPV---GSARTVKSPSLNSFGS---------S 994

  Fly  4767 PD 4768
            ||
plant   995 PD 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	11/29 (38%)
		RCC1	4154..4203	CDD:278826	24/49 (49%)
		RCC1	4206..4257	CDD:278826	18/62 (29%)
		RCC1	4260..4309	CDD:278826	14/48 (29%)
		RCC1	4312..4360	CDD:278826	16/48 (33%)
		RCC1	4364..4413	CDD:278826	19/48 (40%)
		HECTc	4509..4880	CDD:238033	62/289 (21%)
		HECTc	4553..4878	CDD:214523	51/241 (21%)
AT5G19420	NP_001190338.1	PH_PLC_plant-like	57..164	CDD:270171
		RCC1_2	348..377	CDD:290274	9/28 (32%)
		RCC1	365..413	CDD:278826	16/49 (33%)
		RCC1	416..466	CDD:278826	24/49 (49%)
		RCC1	470..518	CDD:278826	18/47 (38%)
		RCC1	534..582	CDD:278826	14/47 (30%)
		RCC1	585..634	CDD:278826	16/49 (33%)
		RCC1	639..686	CDD:278826	19/46 (41%)
		FYVE	690..757	CDD:279674	12/81 (15%)
		Tup_N	906..956	CDD:285748	7/49 (14%)
		BRX_N	949..984	CDD:290432	8/38 (21%)
		BRX_assoc	990..1057	CDD:293233	4/16 (25%)
		BRX	1064..1118	CDD:285568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3500
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820