DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and AT5G16040

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_197108.1	Gene:	AT5G16040 / 831461	AraportID:	AT5G16040	Length:	396	Species:	Arabidopsis thaliana

Alignment Length:	394	Identity:	127/394 - (32%)
Similarity:	187/394 - (47%)	Gaps:	40/394 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  4048 ASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGG 4112
            |:::..||....||||.......:..:..:||.......:.||.::..|:..|||||..|:...|
plant     4 ATSVIAWGSGEDGQLGLGTDEEKELASVVDALEPFNVRSVVGGSRNSLAICDDGKLFTWGWNQRG 68

  Fly  4113 RLG-VGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGH------ 4170
            .|| ...:.:.:.|:|:.||.:|.:.:.|:  ||.||||:..:|..||||..|.|:.|.
plant    69 TLGHPPETKTESTPSLVKSLANVKIVQAAI--GGWHCLAVDDQGRAYAWGGNEYGQCGEEPSKDE 131

  Fly  4171 -GNRMSYD--RPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPK 4232
             |..:..|  .||  .....::|..:|.|..||..:|..|:|.|||:    ....||.:....|.
plant   132 TGRPVRRDIVIPK--RCAQQLTVRQVAAGGTHSVVLTREGYVWTWGQ----PWPPGDIKQISVPV 190

  Fly  4233 LVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVV 4297
            .|:.|...|.|.:    |....|.:.:|..:|:||:.:||:||.|.:.....|..::.|..|.:|
plant   191 RVQGLENVRLIAV----GAFHNLALKEDGTLWAWGNNEYGQLGTGDTQPRSYPIPVQGLDDLTLV 251

  Fly  4298 KVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRR--PKKVAALQGKKIISIATGSLHCVA 4360
            .:..|...|.|||..|.||.||:|:..|||.|..|...:  |:||..|.|:.||.::.|..|.||
plant   252 DIAAGGWHSTALTNEGEVYGWGRGEHGRLGFGDNDKSSKMLPQKVNLLAGEDIIQVSCGGTHSVA 316

  Fly  4361 CSDSGEVYTWGDNDEGQLGDG-TVTAIQRPRLVAAL--------------QGKHIVK-VTCGSAH 4409
            .:..|.::::|..|.|:||.| .||..|...|...:              .||.|.| |.||..|
plant   317 LTRDGRIFSFGRGDHGRLGYGRKVTTGQPLELPIHIPPPEGRFNHTDEEDDGKWIAKHVACGGRH 381

  Fly  4410 TLAL 4413
            |||:
plant   382 TLAI 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	13/29 (45%)
		RCC1	4154..4203	CDD:278826	17/57 (30%)
		RCC1	4206..4257	CDD:278826	14/50 (28%)
		RCC1	4260..4309	CDD:278826	15/48 (31%)
		RCC1	4312..4360	CDD:278826	20/49 (41%)
		RCC1	4364..4413	CDD:278826	21/64 (33%)
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
AT5G16040	NP_197108.1	ATS1	6..339	CDD:227511	111/344 (32%)
AT5G16040	NP_197108.1	RCC1	320..385	CDD:395335	21/64 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3500
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820