DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and AT3G55580

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_191117.1	Gene:	AT3G55580 / 824723	AraportID:	AT3G55580	Length:	488	Species:	Arabidopsis thaliana

Alignment Length:	394	Identity:	103/394 - (26%)
Similarity:	162/394 - (41%)	Gaps:	112/394 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  4043 LSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTP------------------CEALSLLRPVQLAG 4089
            ::||....:        ||.....|...:||.|                  |.|::..:.|...|
plant    86 ITWGSTDDL--------GQSYVTSGKHGETPEPFPLPPEVCVQKAEAGWAHCVAVTENQQVYTWG 142

  Fly  4090 GEQSLFAVTPDGKLFATGYG-----------------SGGRLGVGGSDSW--------------- 4122
            ..:.:    |.|::|....|                 |.|:...||:.|.
plant   143 WRECI----PTGRVFGQVDGDSCERNISFSTEQVSSSSQGKKSSGGTSSQVEGRGGGEPTKKRRI 203

  Fly  4123 -------------------AIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKL 4168
                               |:|.|:.....|.:  |:|.:||:|.|||:..|:|:.||.|.:|:|
plant   204 SPSKQAAENSSQSDNIDLSALPCLVSLAPGVRI--VSVAAGGRHTLALSDIGQVWGWGYGGEGQL 266

  Fly  4169 GHGNRM---------------SYDR--------PKLVE--HLNGMSVADIACGSAHSAAITASGH 4208
            |.|:|:               ||.:        ..:|:  .:.|..|..||||..|||.||.:|.
plant   267 GLGSRVRLVSSPHPIPCIEPSSYGKATSSGVNMSSVVQCGRVLGSYVKKIACGGRHSAVITDTGA 331

  Fly  4209 VLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGK 4273
            :||:|.|.||:.|.|.::|:|.|..|.:|||.|..::|.|..  .|.|.:.|.:|:::|...:|:
plant   332 LLTFGWGLYGQCGQGSTDDELSPTCVSSLLGIRIEEVAAGLW--HTTCASSDGDVYAFGGNQFGQ 394

  Fly  4274 LGRGGSDGCKLPYKIE--SLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRR 4336
            ||.|......||..:|  :|..:.|..:.||::.:..:|..|.|:.||...:.:||.|.|.....
plant   395 LGTGCDQAETLPKLLEAPNLENVNVKTISCGARHTAVITDEGRVFCWGWNKYGQLGIGDVIDRNA 459

  Fly  4337 PKKV 4340
            |.:|
plant   460 PAEV 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	13/29 (45%)
		RCC1	4154..4203	CDD:278826	22/73 (30%)
		RCC1	4206..4257	CDD:278826	20/50 (40%)
		RCC1	4260..4309	CDD:278826	14/50 (28%)
		RCC1	4312..4360	CDD:278826	10/29 (34%)
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
AT3G55580	NP_191117.1	ATS1	83..463	CDD:227511	102/392 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820