DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and AT3G47660

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001325559.1	Gene:	AT3G47660 / 823920	AraportID:	AT3G47660	Length:	990	Species:	Arabidopsis thaliana

Alignment Length:	764	Identity:	196/764 - (25%)
Similarity:	310/764 - (40%)	Gaps:	165/764 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  2955 SAGVGPGSTAGAGAVSTSHEEAAAAPEQDLPCTVMVWG--LNDKEQLGGL--KGSKVKVPTFSQT 3015
            |.||.....:.:.|||:|.:.:.....:.| |.|.|||  :.|....||:  .||...:.|.| .
plant   262 SPGVDTSKYSISSAVSSSSQGSTFEDLKSL-CDVFVWGESIGDGLLGGGMHKSGSSSSLMTDS-F 324

  Fly  3016 ISRLRPIHIAGGSKSL-------FIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVV 3073
            :.::...|:|..::|:       .:|::.|::|:.||.:.||||.||...||.|..:.......|
plant   325 LPKVLKSHVALDAQSISCGTNYAVLVTKQGQMYSWGEESGGRLGHGVCSYVPHPKLIDEFNGSTV 389

  Fly  3074 KKVAVHSGGKHALALTLDGKVFSWGEGED--GKLGHGNRTTLDKP-RLVEALRAKKIRDVACGSS 3135
            :  ....|..|..|:|..|.:::||:|:.  |.||.|:..:..|| |::..:....::.::||..
plant   390 E--LADCGEFHTCAVTASGDLYAWGDGDHNAGLLGLGSGASHWKPVRILGQMEGIYVKAISCGPW 452

  Fly  3136 HSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGS-RDAQTLAL----T 3195
            |:|.::|:|:|:|:|.|.:|.|||||..:...|:.|.||.|.|.::.|||. ..|..:::    |
plant   453 HTAFVTSEGKLFTFGDGTFGALGHGDRISTNIPREVEALNGCRTIKAACGVWHSAAVVSVFGEAT 517

  Fly  3196 EDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDY 3260
            ..|.:|:|||||.|:||.|..|....|..:..|......|:.||...::||:.:|:|:..|..|
plant   518 SSGKLFTWGDGDDGRLGHGDIECRLIPSCVTELDTTSFQQVACGQSITVALSMSGQVYAMGTAD- 581

  Fly  3261 YRLGHGGDQH--VRKPQPI-GGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFV 3322
                   ..|  ||.|..| |||....|..||.|..|...:....:||.||...:||.|.|:|..
plant   582 -------PSHDIVRAPSCIEGGLGKSFVQEVACGFHHIAVLNSKAEVYTWGKGSNGQLGHGDTEY 639

  Fly  3323 NKKPALVIGLDAVFVNRVACGSSH--SIAWGLPNASSDEEKRGPV--PFSSTRDPLGGSSLGIYE 3383
            ...|.||..|....|.:|.|||::  :|....|...:|..|....  ||:..|......:.|...
plant   640 RCMPTLVKALKGKQVRKVVCGSNYTATICLHKPITGTDSTKCSGCRHPFNYMRKLHNCYNCGSVF 704

  Fly  3384 AETMQTLKQEA--------KP--------LNQSSLSESLALETPAAR--QAAL--GHVLRAMSIL 3428
            ..:..:.|..|        :|        :....:.||||....:||  .|:|  .:.:..:.|.
plant   705 CNSCTSKKSLAAAMAPKTNRPYRVCDDCYIKLEGIRESLATPANSARFSNASLPSSYEMDEIGIT 769

  Fly  3429 QARQLIVAALTSHSKVNFKERGAVGGEEDHLIGGPIMGAPLQLAETIAQGGGEAPADATDAGLQ- 3492
            ..|||:                                                ..|:.|...|
plant   770 PQRQLL------------------------------------------------RVDSFDFFRQT 786

  Fly  3493 EHSPEAAVDALTGGMSGGANTLPPLSAGPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMS 3557
            :|:....:    |..|||:.|            .|:..::.:.||.:...:.:          :|
plant   787 KHADLKTI----GETSGGSCT------------SSIHSNMDIKGSFNLKGIRR----------LS 825

  Fly  3558 VMAATMTQQEEMLSHISHCHGLDDFGGLL------GEP-EAKSLVELLKLAVCGRCGPPSTSQTI 3615
            .:.:..:.|||......||....|...|:      |.| ..:..|||..|::  :..|..:..|.
plant   826 RLTSFDSVQEEGKQRTKHCASKSDTSSLIRHSVTCGLPFSRRGSVELFPLSI--KSSPVESVATT 888

  Fly  3616 ADTLISLGAGTPAVAAMLLETCITELEDLCTSRHCLGKLPKPVMQESSH 3664
            :|                ..|.||:.|       .|.::||...|..||
plant   889 SD----------------FTTDITDHE-------LLQEVPKKSNQCLSH 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826	16/50 (32%)
		RCC1	3091..3140	CDD:278826	15/51 (29%)
		RCC1	3144..3194	CDD:278826	21/50 (42%)
		RCC1	3197..3246	CDD:278826	17/48 (35%)
		RCC1	3250..3298	CDD:278826	17/50 (34%)
		RCC1	3302..3350	CDD:278826	19/49 (39%)
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
AT3G47660	NP_001325559.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3500
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820