DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and AT3G03790

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001189802.1	Gene:	AT3G03790 / 821145	AraportID:	AT3G03790	Length:	1099	Species:	Arabidopsis thaliana

Alignment Length:	934	Identity:	219/934 - (23%)
Similarity:	344/934 - (36%)	Gaps:	268/934 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  4066 EGSRIKTPTPCEALSLLRPVQLAGGEQSL---FAVTP------------DGKLFATGYGSGGRLG 4115
            |||.:...:   |||:|:.   .||..:|   :.:||            ..:|.|.|.....|.|
plant    35 EGSLVDVDS---ALSILKK---TGGNINLRNAYGLTPLHIAVWRNHIPIVRRLLAAGADPDARDG 93

  Fly  4116 VGGSDSWAIPTLLGSLQ--HVFVKKVAVNSG-------------------------GKHCLALTT 4153
            ..|   |:  :|..:|.  |:.|..|.::||                         |:...::.|
plant    94 ESG---WS--SLHRALHFGHLAVASVLIDSGASFTLEDIKLRTPVDLVSGPVAQVIGEQQSSVAT 153

  Fly  4154 EGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYG 4218
              ||::||.|.:.:||.||:.....|..|:.|:|..:..::....||.||:..|.|.|||.||.|
plant   154 --EVFSWGNGANYQLGTGNQHVQKVPGRVDSLHGCFIKLVSAAKFHSVAISTHGEVYTWGFGRGG 216

  Fly  4219 RLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCK 4283
            ||||.:                  .||..|    |...||
plant   217 RLGHPE------------------FDIHSG----QAAVIT------------------------- 234

  Fly  4284 LPYKIESLAGLG---VVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQG 4345
             |.::  ::|||   |..|......:|..|:.|.|||||.....:||:.|||....|:||.:|:.
plant   235 -PRQV--ISGLGSRRVKAVAAAKHHTVIATEGGDVYTWGSNREGQLGYTSVDTQATPRKVTSLKA 296

  Fly  4346 KKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQR--PRLVAALQGKHIVKVTCGSA 4408
             ||::::..:.|....||.|||:|||.|.|||||.||..:...  ||||..|:||....:.....
plant   297 -KIVAVSAANKHTAVVSDCGEVFTWGCNKEGQLGYGTSNSASNYSPRLVDYLKGKVFTAIASSKY 360

  Fly  4409 HTLALSTSQ----------------LSERLRPLPNPPLEYDLVRDLAPEALHARLILLHHFSELV 4457
            |||.|....                :|..|:...|..|.:...|.|...|:.|.::   |...|.
plant   361 HTLVLRNDGEVYTWGHRLVTPRRVIISRNLKKAGNTLLNFHRRRPLRLTAIAAGMV---HSLALA 422

  Fly  4458 CPCLAMLPISGDLS-----LGALKDVLVYNIKEAAF-RKVIQTT---MVRDKQHGPVI--ELNRI 4511
            ........:|.|.:     |.:|....|.:|....: ...:.:|   .:.|.::|..|  .|:|:
plant   423 EDGAFFYWVSSDSNLRCQQLHSLHGKTVVSISAGKYWASAVTSTGEVYMWDGKNGKDIAPSLSRL 487

  Fly  4512 -QVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESI 4575
             .:||:.....|...:..:.|::......:.|...:.|              ..|.|....:|.:
plant   488 HNLKRATTVAVGETHLLVVGSLYHPAYAPIVLKKSQTL--------------QADKCREEENEEL 538

  Fly  4576 AE--MCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQ----------MNMFRFLGVL 4628
            .|  |.|::::.:|...:...|.:..         :.|:|.|:.:          .|..:    |
plant   539 DEGFMFDDVESVNVLQSVQYDNPKER---------IVPSLKSLCEKVAAECIVEPRNAIQ----L 590

  Fly  4629 MGIAVRTGSPLSINLAEPVWRQLTGEVLR---------PTDLTEVDRDYVAGLLCIRNMDDDPKL 4684
            :.||...|       ||.:.:.....|:|         |..:.....|.:|.|   ..:.||...
plant   591 LEIADSLG-------AEDLKKYCEDIVIRNLDFILTFSPQSIANTSPDVLANL---EKLLDDRSS 645

  Fly  4685 FTALELPFSTSSA-----------RGHEVPLSTRYTHISPRNRAEYVRLALGFRLHEF----DE- 4733
            .|....|..|.:|           ......|.||.:|:      ::.....|.|:..|    ||
plant   646 ETWSSRPLPTPTATFPVVIDSEEEESESDILRTRDSHV------KHFSSIGGTRMDSFLQPEDEL 704

  Fly  4734 ------QVKAVRDGMSKVIPV-------PLLSLFSAAELQAMV-CGSPDIPLGL----------- 4773
                  :|:|:|..:.::..:       .||.....|:||..: ..|..:.||:
plant   705 TQHNSKEVRALRKKLQQIEILEAKQSRGQLLDGQQIAKLQKKLDIESSLVELGIPVEEFPEAKAT 769

  Fly  4774 ----LKSVATYKGFDPSSA------LVTW--FWEVMEEF-TNQERSL-----FLRFVWGRTRLPR 4820
                |:..|..||......      :.|:  |.||..|. |.|::.:     .::...|:|.|..
plant   770 TALPLEGKANKKGKKKKKGNQRFVQVETFPEFGEVKVEIDTMQDKEIEEICEAIKPKGGKTMLDT 834

  Fly  4821 T-IADF-RGRDFV-LQVLEKNPPD 4841
            | |:.| :..||| |...:.||||
plant   835 TMISGFPKESDFVSLSQKKDNPPD 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	11/54 (20%)
		RCC1	4154..4203	CDD:278826	15/48 (31%)
		RCC1	4206..4257	CDD:278826	16/50 (32%)
		RCC1	4260..4309	CDD:278826	7/51 (14%)
		RCC1	4312..4360	CDD:278826	18/47 (38%)
		RCC1	4364..4413	CDD:278826	24/50 (48%)
		HECTc	4509..4880	CDD:238033	82/417 (20%)
		HECTc	4553..4878	CDD:214523	75/372 (20%)
AT3G03790	NP_001189802.1	ANK	29..137	CDD:238125	26/112 (23%)
		Ank_2	29..126	CDD:289560	26/101 (26%)
		ANK repeat	29..59	CDD:293786	10/29 (34%)
		ANK repeat	61..92	CDD:293786	5/30 (17%)
		ANK repeat	95..126	CDD:293786	9/35 (26%)
		RCC1	154..201	CDD:278826	15/46 (33%)
		RCC1	205..259	CDD:278826	24/103 (23%)
		RCC1	264..311	CDD:278826	18/47 (38%)
		RCC1	315..365	CDD:278826	24/49 (49%)
		SPOP_C_like	586..>615	CDD:269810	9/39 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820