DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and RCC1L

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_110425.2	Gene:	RCC1L / 81554	HGNCID:	14948	Length:	464	Species:	Homo sapiens

Alignment Length:	474	Identity:	131/474 - (27%)
Similarity:	187/474 - (39%)	Gaps:	118/474 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  2957 GVGPGSTAGAGAVSTSHEEAAAAPEQDLPCT------------VMVWGLNDKEQLGGLKGSKVKV 3009
            |:|.|....||. |.|..|||.| |.::|..            |.|||.:....||        |
Human    20 GLGRGHWTAAGR-SRSRREAAEA-EAEVPVVQYVGERAARADRVFVWGFSFSGALG--------V 74

  Fly  3010 PTF------------SQTISRLRPI-----------HIAGGSKSLFIVSQDG---KVYACGEGTN 3048
            |:|            ::...|::|:           ..|.|.....:.|:..   ||:..|...:
Human    75 PSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKD 139

  Fly  3049 GRLGL---------GVTHNV-PLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDG 3103
            .:||.         |..:.: |.|..||:.|....:.:.|..|..|:|.||....|||.|....|
Human   140 SQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYG 204

  Fly  3104 KLGHGNRTTLDKPRLVEALRAKKIRD-------VACGSSHSAAISSQGELYTWGLGEYGRLGHGD 3161
            :.|   |..::.....|:.|..:::|       ||||..||..::.:||:|:.|.|..|:.|.|.
Human   205 QCG---RKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGH 266

  Fly  3162 -NTTQLKPKLVTALAGRRVVQVA----CGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDT 3221
             |.|....||...|||..|:|||    |      .||::.||.:|.||:.::.:|   .|....|
Human   267 YNITSSPTKLGGDLAGVNVIQVATYGDC------CLAVSADGGLFGWGNSEYLQL---ASVTDST 322

  Fly  3222 PHEIER---LSGIGVV-QIECGAQFSLALTRAGEVWTWGKGDYYRLGHGG---DQHVRK--PQPI 3277
            ...:.|   .||:|.| |..||......|...|.|:.||   |..||.|.   :..|.:  |..:
Human   323 QVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTL 384

  Fly  3278 GGLR----GRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVN 3338
            .||.    ..:|..:..|..|..|:|:.|:::.||.|..|..|.|..           .|..|..
Human   385 FGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRL-----------EDQYFPW 438

  Fly  3339 R---------VACGSSHSI 3348
            |         ||||..|.:
Human   439 RVTMPGEPVDVACGVDHMV 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826	15/63 (24%)
		RCC1	3091..3140	CDD:278826	16/55 (29%)
		RCC1	3144..3194	CDD:278826	21/54 (39%)
		RCC1	3197..3246	CDD:278826	16/52 (31%)
		RCC1	3250..3298	CDD:278826	15/56 (27%)
		RCC1	3302..3350	CDD:278826	15/56 (27%)
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
RCC1L	NP_110425.2	RCC1 1. /evidence=ECO:0000255, ECO:0000305\|PubMed:28608466	58..124		13/73 (18%)
		RCC1 2. /evidence=ECO:0000255, ECO:0000305\|PubMed:28608466	128..191		16/62 (26%)
		RCC1	130..189	CDD:278826	15/58 (26%)
		RCC1_2	176..205	CDD:290274	10/28 (36%)
		RCC1 3. /evidence=ECO:0000255, ECO:0000305\|PubMed:28608466	193..247		16/56 (29%)
		RCC1	195..245	CDD:278826	16/52 (31%)
		RCC1_2	232..261	CDD:290274	11/28 (39%)
		RCC1 4. /evidence=ECO:0000255, ECO:0000305\|PubMed:28608466	248..300		22/57 (39%)
		RCC1	248..298	CDD:278826	21/55 (38%)
		RCC1	301..351	CDD:278826	16/52 (31%)
		RCC1 5. /evidence=ECO:0000255, ECO:0000305\|PubMed:28608466	302..353		16/53 (30%)
		RCC1 6. /evidence=ECO:0000255, ECO:0000305\|PubMed:28608466	354..411		16/59 (27%)
		RCC1_2	396..425	CDD:290274	9/28 (32%)
		RCC1 7. /evidence=ECO:0000255, ECO:0000305\|PubMed:28608466	412..461		15/57 (26%)
		RCC1	412..455	CDD:278826	14/53 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820