Protein Alignment HERC2 and WWC2

DIOPT Version :9

• Sequence 1: NP_608388.2
• Gene: HERC2 / 33035
• FlyBaseID: FBgn0031107
• Length: 4912
• Species: Drosophila melanogaster
• Sequence 2: XP_011530571.1
• Gene: WWC2 / 80014
• HGNCID: 24148
• Length: 1216
• Species: Homo sapiens
• Alignment Length: 1459
• Identity: 255/1459 - (17%)
• Similarity: 452/1459 - (30%)
• Gaps: 524/1459 - (35%)

  Fly  1249 DRLNRALGEGELRDGDDMGWPGIICRGGPKGGPPP---------------ADPETHYVRRADMEN 1298
            |||.:.|...:. .||::.|      |...|..|.               .||...:  |.:.|.
Human    43 DRLTKPLSFADC-VGDELPW------GWEAGFDPQIGVYYIDHINKTTQIEDPRKQW--RGEQEK 98

  Fly  1299 LLLDGSRCIILAGYVCDLSGYNCESETLRSVLDSGLGKDLTAEMSSQVHRTAME--HILEHH--- 1358
            :|.|         |:              ||....|             ||..|  |:.|..
Human    99 MLKD---------YL--------------SVAQDAL-------------RTQKELYHVKEQRLAL 127

  Fly  1359 KLGKYM-VQASTEEKSSA-----PGPSRLTHFSSECALAQLLGLVANLMCSGPALQPAELQ---- 1413
            .|.:|: :..:.:||||:     .|.|..|.:..:...|::         |...|:..:|:
Human   128 ALDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDPDILKAEI---------STTRLRVKKLKRELS 183

  Fly  1414 ---------------CRQLDKSSLLSGGLQLLQPSNPFDEEKG---EARSSHSCHSTAGNTPTEL 1460
                           .:|:||.  :|||    |......|.|.   |.:|.....|:......:|
Human   184 QMKQELLYKEQGFETLQQIDKK--MSGG----QSGYELSEAKAILTELKSIRKAISSGEKEKQDL 242

  Fly  1461 PPPLPMQQQ---LAPGRGKSQLQLRADAFISGLAEARV-----SEPPVAAWLALTERYCKAHNLM 1517
            ...|...|:   |....|:|:..||.....|.|..:|.     |:..::..:.:..|...|..:.
Human   243 MQSLAKLQERFHLDQNIGRSEPDLRCSPVNSHLCLSRQTLDAGSQTSISGDIGVRSRSNLAEKVR 307

  Fly  1518 WHQEFATEHPVQELERLLSAVLIRHQYLGGLVLNALETEVPPPRQLGEIIRLVHQAKWSVVRTRQ 1582
            ...::      :|.:|.::.:.|.        |:.|::|..|    |.:.  :.:.|..::..::
Human   308 LSLQY------EEAKRSMANLKIE--------LSKLDSEAWP----GALD--IEKEKLMLINEKE 352

  Fly  1583 QLNRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRLPILQRPPRFKMLVRRLLQELRSSRQPA 1647
            :|           |:.|:|        ::||:|                 .:..|:.|.:.||..
Human   353 EL-----------LKELQF--------VTPQKR-----------------TQDELERLEAERQRL 381

  Fly  1648 KPEDLLNASIQQEQEKKPQSMPKQELEE----QEEEETLLRRLNERQIHGEGELDPALMQDIVDF 1708
            : |:||:.          :..|.:.|.|    :|..:.||::|.
Human   382 E-EELLSV----------RGTPSRALAERLRLEERRKELLQKLE--------------------- 414

  Fly  1709 ALQDSCDVETARRAMYCQMQRYQLRLAGLQIVQQLLELHGLLDAAQYSLLNGFLGLHLKSTSSGG 1773
                    ||.:...|                     ||..|.:...|.|:...|..|.|.:|..
Human   415 --------ETTKLTTY---------------------LHSQLKSLSASTLSMSSGSSLGSLASSR 450

  Fly  1774 GS--TGSGSSLHVLGQLNMISAYQKARLLLAQSRVLDWAVRELRRLVNQEQQGHARGKDSTNLGT 1836
            ||  |.|..||:.|....:..:.|..::.:.....||:.:        ||:.|:......|.:..
Human   451 GSLNTSSRGSLNSLSSTELYYSSQSDQIDVDYQYKLDFLL--------QEKSGYIPSGPITTIHE 507

  Fly  1837 YVLLKRLPRARFLLSVFGLLAKELGPNELGFLINSGLLGTVLGLLAQTGGEGATGGQVHGELSIL 1901
            ..::|                   .|::.|   .|||.|..      ....|.|........|:
Human   508 NEVVK-------------------SPSQPG---QSGLCGVA------AAATGHTPPLAEAPKSV- 543

  Fly  1902 YEDSVLKQKSSKAQLSGPDLAKLMKIGTRIVRGADWKWGDQDGNPPG-----EGRIISEVGEDGW 1961
               :.|..:||.:.||                            |||     ||........|
Human   544 ---ASLSSRSSLSSLS----------------------------PPGSPLVLEGTFPMSSSHD-- 575

  Fly  1962 VRVEWYTGATNSYRMGKEGQYDLQLADSALNVASPTEPEREDVSGSEASPTSDSHPSKLLRHCAA 2026
            ..:..:|.......:..... |:.|.::.:.:.|       |..|:..|.:.|    |.|..||.
Human   576 ASLHQFTADFEDCELSSHFA-DISLIENQILLDS-------DSGGASQSLSED----KDLNECAR 628

  Fly  2027 KLLQILAVGTGLHGAQLDKDALRGMTSMFRTIIYPKPSMSNISYALGWLNLGFIRAISGDCPRLC 2091
               :.|..||    |.::|.             .||   ..:.:.||........|:|.:
Human   629 ---EPLYEGT----ADVEKS-------------LPK---RRVIHLLGEKTTCVSAAVSDE----- 665

  Fly  2092 LELSTPGWLSHYLSLLEQPAGNEAGVYRQLHCLRLLQLILAQWGAEEEPRMPALVHQLFATLGRI 2156
               |..|....|.:.::||:..|...|                 :||
Human   666 ---SVAGDSGVYEAFVKQPSEMEDVTY-----------------SEE------------------ 692

  Fly  2157 ALHCPGDASLLPTAEGKARVLLTASHSGSVAEELVALLRRLHTLPSWNPVINSFL---AQKLCVA 2218
                  |.:::.||:.:..:...|..|..:.  ::|.||.||          :||   ..|:...
Human   693 ------DVAIVETAQVQIGLRYNAKSSSFMV--IIAQLRNLH----------AFLIPHTSKVYFR 739

  Fly  2219 AELLAEQSHSTALDSEQVFVLGVLGAMGGHDLRPRVGLHCFHEGSHMVIASFTPKGRCLLAPGGV 2283
            ..:|...:..:.|...:|              .|......|::...:.|:....:.:.|
Human   740 VAVLPSSTDVSCLFRTKV--------------HPPTESILFNDVFRVAISQTALQQKTL------ 784

  Fly  2284 GSGVGFVKVQLPAVMPH-----LDHTVFSLSRLPMNEMLLNAWTVLLYGPAPELRELPSSADGRL 2343
                   :|.|.:|..|     |..|..||:.||.:..:...|..||  |:   :::|...:...
Human   785 -------RVDLCSVSKHRREECLAGTQISLADLPFSSEVFTLWYNLL--PS---KQMPCKKNEEN 837

  Fly  2344 DLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDAESQQPGEQDQQLS 2408
            :.::.:..|..:..:..:.|         ..|..|....:.|.  |.:.:..|.::.|:::.:..
Human   838 EDSVFQPNQPLVDSIDLDAV---------SALLARTSAELLAV--EQELAQEEEEESGQEEPRGP 891

  Fly  2409 SGSGQEPQLLIQC------ILLRATQASPVKACYSYMDLATAAL--------------NCIQSLA 2453
            .|.......|. |      :..|.|    ||...:.:..|:..:              :|.:.|:
Human   892 DGDWLNTYFLC-CWELKDDVFTRLT----VKPLLTMLREASDEIVAEKEAEVKLPEDSSCTEDLS 951

  Fly  2454 T-QAHQELSEGGGVPPNGRA---LSSPPQ--PTMVHGVPVYNVARKEQKPSEQVEQKSKWPAAAT 2512
            : .:..|::|.|....:..|   .|.||.  ||:|.         ||....|          ||.
Human   952 SCTSVPEMNEDGNRKESNCAKDLRSQPPTRIPTLVD---------KETNTDE----------AAN 997

  Fly  2513 DAQLIGQIMEMGFTRRTVELALKQLSLQAEIMPTPEQIVQWI--LEHPDVCANTIEEDTLPLASS 2575
            |...:........:.|........:.::::.. :|.:..|:|  |...|..::|:.:.:|.:.:|
Human   998 DNMAVRPKERSSLSSRQHPFVRSSVIVRSQTF-SPGERNQYICRLNRSDSDSSTLAKKSLFVRNS 1061

  Fly  2576 ASSHDPEAD----------SDNECPSSNS 2594
            .........          :..|||...|
Human  1062 TERRSLRVKRTVCQSVLRRTTQECPVRTS 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597	14/77 (18%)
		MIB_HERC2	1928..1987	CDD:284184	8/63 (13%)
		UBA_HERC2	2515..2559	CDD:270585	5/45 (11%)
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
WWC2	XP_011530571.1	WW	12..41	CDD:278809
		WW	59..88	CDD:278809	4/34 (12%)
		DUF342	<283..385	CDD:302792	24/158 (15%)
		YlqD	351..>428	CDD:287979	26/173 (15%)
		C2_Kibra	700..823	CDD:176062	29/161 (18%)
		vWFA	<1058..>1153	CDD:294047	5/33 (15%)
		Phage_Nu1	<1117..1192	CDD:294991

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900