DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and MAGIX

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_079135.3 Gene:MAGIX / 79917 HGNCID:30006 Length:334 Species:Homo sapiens


Alignment Length:351 Identity:80/351 - (22%)
Similarity:110/351 - (31%) Gaps:110/351 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1259 ELRDGDDMGWPGIICRGGPKGGPPPADPET-HYVRRADMENL----LLDGSRCIILAGYVCDLSG 1318
            |.|.||.....|  .||| :|..|.|.|.. ..:.|.|...|    .:|.:..:..||       
Human     2 EPRTGDAADPRG--SRGG-RGPSPLAGPSARQLLARLDARPLAARAAVDVAALVRRAG------- 56

  Fly  1319 YNCESETLR-------SVLDSGLGKDLTAEMSSQVHRTAMEHILEHHKL-----GKYMVQASTEE 1371
                 .|||       |||||.   |:....|...|.|.::|..:|..|     ...::|.... 
Human    57 -----ATLRLRRKEAVSVLDSA---DIEVTDSRLPHATIVDHRPQHRWLETCNAPPQLIQGKAR- 112

  Fly  1372 KSSAPGPSRLT-HFSSE-----CALAQLLG-----------LVANLMCSGPALQPAELQCRQLDK 1419
              |||.||:.: |||.|     ......||           .|..|:..|||     .:|.:|:.
Human   113 --SAPKPSQASGHFSVELVRGYAGFGLTLGGGRDVAGDTPLAVRGLLKDGPA-----QRCGRLEV 170

  Fly  1420 SSLL---------------------SGGLQL-LQPSNPFDEEKGEARS-SHSCHSTAGNTPTELP 1461
            ..|:                     :||.|| |....|.:...|:.|. .........:.|...|
Human   171 GDLVLHINGESTQGLTHAQAVERIRAGGPQLHLVIRRPLETHPGKPRGVGEPRKGVVPSWPDRSP 235

  Fly  1462 PP------------------LPMQQQLAPGRGKSQ--LQLRADAFISGLAEARVSEP------PV 1500
            .|                  .|.:..|...||..:  .:..||.......|.|..:|      ..
Human   236 DPGGPEVTGSRSSSTSLVQHPPSRTTLKKTRGSPEPSPEAAADGPTVSPPERRAEDPNDQIPGSP 300

  Fly  1501 AAWLALT-ERYCKAHNLMWHQEFATE 1525
            ..||..: ||..:|..:....:.|.|
Human   301 GPWLVPSEERLSRALGVRGAAQLAQE 326

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597 21/88 (24%)
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
MAGIXNP_079135.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 11/26 (42%)
PDZ_signaling 124..206 CDD:238492 18/86 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 209..306 16/96 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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