DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and herc5.2

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	XP_005160175.1	Gene:	herc5.2 / 794323	ZFINID:	ZDB-GENE-090311-16	Length:	987	Species:	Danio rerio

Alignment Length:	935	Identity:	212/935 - (22%)
Similarity:	376/935 - (40%)	Gaps:	195/935 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  4075 PCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHV----F 4135
            |.:.|...:.:|:|.|:|...|::.||:||..|..:.|:||:....:     |:.|.||:    .
Zfish   111 PLKGLDNTKVIQIACGDQHSVALSNDGQLFVWGENAHGQLGLRKEQA-----LIQSPQHLQSLCG 170

  Fly  4136 VKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHS 4200
            :....:::||.|...|:..|.|:.||....|:||.|:......|.:|:.|:|.....|:||..|:
Zfish   171 IPVAQISAGGNHSFVLSLSGVVFGWGSNSAGQLGLGDTTDRFVPTIVKSLSGKKTVSISCGGEHT 235

  Fly  4201 AAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWS 4265
            |.::..|.|.|:|.|.:|:|||...:|:..|:||..|.|.:...:.||......| :...:.::|
Zfish   236 ATLSKGGTVFTFGSGGFGQLGHNSLKDEHHPRLVAELWGSKVSQVTCGRHHTLVL-VALTNRIYS 299

  Fly  4266 WGDGDYGKLGRGGS------------DGCKLPYKIESLAGLGVVKVECGSQFSVAL--------- 4309
            :|.|..|:||.|..            ..|...:.:|        |:..|.:.|.||
Zfish   300 FGCGMQGQLGNGEQVKQSVPLPVLLPTDCNCEFTME--------KIIAGEKHSFALFFKNPGNES 356

  Fly  4310 TK-----SGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIA---TGSLHCVACSDS-- 4364
            ||     :|.:.|.......|...||.......|::     ||:.|.|   .||....:..:.
Zfish   357 TKPKSSMNGGILTLNDRMIDRWVSGSYPWPTVKKEI-----KKVFSSAVCLNGSFLKPSLDEQDF 416

  Fly  4365 ---GEVYTWGDNDEGQLGDGTVTAIQR----------------------PRLVAALQ-------- 4396
               |:.::...::|..:.: .|..||:                      |.|:..|:
Zfish   417 DLVGKSFSKLTDNEKVISE-VVKVIQQTLLPSLNPKPAHEESLRLYLLLPELIKGLEQYQRSELN 480

  Fly  4397 ---GKHIVKVTCGSAHTLALSTSQL-SERLRPLPN-------PPLEYDLVRDLAPEALHAR-LIL 4449
               ...|:::...:...|.:..|:| .:.|:.|..       ..::|..|..:..:..|.: |:.
Zfish   481 KALASKILQLNSAAREMLEMFWSKLPDDWLKSLVKLFHKESADLIDYMSVCAMDSDLKHLQNLLR 545

  Fly  4450 LHHFSELVCPCLAMLPISGDLSLGALKDVLVYNIKEAAFRKVIQTTMVRDKQHGPVIE------- 4507
            :...:..|| |.....|:       :.|.::|.|.:  ....:|.|:.......|.::
Zfish   546 ILQMAYKVC-CSTHRDIT-------ISDFIIYEISD--LLNALQATIDDLADWDPFVDYVYMMKL 600

  Fly  4508 --------------------------LNRIQVK---RSRNRCNGLAGID----GMKSVFGQMVQK 4539
                                      .|.:::|   ||.||..|.|..:    ..:|:   ::..
Zfish   601 RDYFIKTLEILVKFPFVADYASKRGIFNHLEIKMIRRSSNRFLGNATFNVLHINRESL---LMDT 662

  Fly  4540 LPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANR 4604
            |..|.|...:..| :.:|.|:||...|..|..:|..:             ||:      ::....
Zfish   663 LKYLRQNTHSFSH-LSRVAFIGEDGIDMRGLSAEFFS-------------LIS------KSFLKW 707

  Fly  4605 DCFLLDPTLSSVLQMN--------MFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDL 4661
            |..:|:...||::..|        .|.:|||:.|:|:.....::|:....::::|..:.....||
Zfish   708 DKKILEVHPSSLVWFNPHHTRGNKNFYYLGVICGMALYNRHHINIDFPLALFKKLLQQKPSLDDL 772

  Fly  4662 TEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTSSARGHEVPLSTRYTHISPRNRAEYVRLALGF 4726
            .|:.......|..:...|::     .::|.|...:.:|||:..:.....::..||.:||.|.:.|
Zfish   773 EELSPVEARSLKNLLKEDEE-----VVDLLFLDFTVKGHELVPNGSQIQVNKVNRQKYVDLYVDF 832

  Fly  4727 RLHEFDEQVKAVRD----GMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSS 4787
               .|::.||...:    |.||..|:...::|...|||.::.|||.......:..|:|:|...|.
Zfish   833 ---VFNKSVKTQFEQFTRGFSKGCPLDAWTMFHPEELQELLHGSPQYNWKEFQQSASYEGCSASD 894

  Fly  4788 ALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNPPDHFLPESYTCFF 4852
            .|:..||.|..|.:.:.:..||.|::|..|:|  ...|..|...:...:...||..||::.|||.
Zfish   895 ELIKNFWTVFFELSEEHKKKFLMFLYGTERVP--AGGFSKRRIKISTRDCPDPDDHLPKAQTCFG 957

  Fly  4853 LLKMPRYSCKAVLLEKLKYAIHFCK 4877
            .|.:|:|:....|..||.:||:.|:
Zfish   958 RLVLPKYTDINTLRNKLTHAINVCE 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	8/29 (28%)
		RCC1	4154..4203	CDD:278826	17/48 (35%)
		RCC1	4206..4257	CDD:278826	18/50 (36%)
		RCC1	4260..4309	CDD:278826	12/60 (20%)
		RCC1	4312..4360	CDD:278826	12/50 (24%)
		RCC1	4364..4413	CDD:278826	10/86 (12%)
		HECTc	4509..4880	CDD:238033	98/388 (25%)
		HECTc	4553..4878	CDD:214523	85/337 (25%)
herc5.2	XP_005160175.1	RCC1_2	120..149	CDD:290274	10/28 (36%)
		RCC1	136..186	CDD:278826	15/54 (28%)
		RCC1	189..238	CDD:278826	17/48 (35%)
		RCC1	242..290	CDD:278826	17/47 (36%)
		RCC1	296..347	CDD:278826	12/58 (21%)
		HECTc	649..985	CDD:294058	90/367 (25%)
		HECTc	678..984	CDD:214523	85/334 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820