DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and sergef

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001072233.1	Gene:	sergef / 779680	XenbaseID:	XB-GENE-6455308	Length:	349	Species:	Xenopus tropicalis

Alignment Length:	327	Identity:	92/327 - (28%)
Similarity:	152/327 - (46%)	Gaps:	45/327 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  4103 LFATGYGSGGRLGVGGSDSWAIPTL-LGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDG 4166
            |:|.|..|.|:||||.:....:|.| :|...|..|.: ::::||.|..|:|..|.||..|:..:|
Frog    11 LYAWGANSYGQLGVGSTQDTPVPQLVIGLPNHETVIR-SISAGGGHSAAVTESGRVYVCGQNSEG 74

  Fly  4167 KLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRP 4231
            :||..:.....:..|.....|:.|:.::||...:..:..:|.:|:.|...|.:||...:.....|
Frog    75 QLGLDHTTDVTQFCLCPGALGLRVSKVSCGWDFTLILAETGELLSCGANTYSQLGRAGAGRSCVP 139

  Fly  4232 KLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGR-----------GGSDGCKLP 4285
            :.| .:...:.||:|.|.  ...|.:||:..::.||.|......|           |.::.|.:|
Frog   140 RPV-GIQKRKVIDVAAGL--RHVLALTDNGQIFQWGSGLASHARRFSPQNPIPPVYGATEPCPVP 201

  Fly  4286 YKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDH----VRRPKKVAA--LQ 4344
                .:.|:....|..||...|||:.:|.:|.||...     ||.:.|    :..|.:|.|  ..
Frog   202 ----GMEGICGKVVTAGSYHCVALSDAGDMYAWGSNK-----HGQLLHPDPFLLHPHRVQAHFFL 257

  Fly  4345 GKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLG-----DGT---------VTAIQRPRLVAAL 4395
            |:.|:::.:|..|.||.:|:|:|:|||..:..|||     :||         :.|.|.|..:.:|
Frog   258 GESIVAVTSGWTHLVAQTDTGKVFTWGRANYSQLGRPPSTEGTGLNETLLEGIPANQVPAWIPSL 322

  Fly  4396 QG 4397
            .|
Frog   323 TG 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	10/29 (34%)
		RCC1	4154..4203	CDD:278826	12/48 (25%)
		RCC1	4206..4257	CDD:278826	13/50 (26%)
		RCC1	4260..4309	CDD:278826	12/59 (20%)
		RCC1	4312..4360	CDD:278826	14/53 (26%)
		RCC1	4364..4413	CDD:278826	15/48 (31%)
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
sergef	NP_001072233.1	RCC1	11..>294	CDD:332518	85/295 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010