DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and Herc3

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001348895.1	Gene:	Herc3 / 73998	MGIID:	1921248	Length:	1050	Species:	Mus musculus

Alignment Length:	1080	Identity:	245/1080 - (22%)
Similarity:	402/1080 - (37%)	Gaps:	302/1080 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  4054 WGHNHRGQLG---GLEGSRIKTPTPCEALSLLRPVQLA-GGEQSLFAVTPDGKLFATGYGSGGRL 4114
            ||:...||.|   .|:|. :..|..|..:|.....::| ||..|:| :..||:::..|..:.|:|
Mouse     4 WGYWSLGQPGISSNLQGI-VAEPQVCRFVSDRSIKEVACGGNHSVF-LLEDGEVYTCGVNTKGQL 66

  Fly  4115 G---VGGSDSWAIPTLLGSL--QHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLG-HGNR 4173
            |   .|..     |..:|:|  ||:    :.|..|..|.|||:..|::::||.|.||:|| ....
Mouse    67 GHEREGNK-----PEQIGALADQHI----IHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTE 122

  Fly  4174 MSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHG-DSEDQLRPKLVEAL 4237
            .|...|:|::.||..::..::||:.|..|:.|.|...||||..:|:||.| :...|..|:.|.:|
Mouse   123 DSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQTSPQRVRSL 187

  Fly  4238 LGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECG 4302
            .|.....:|  :|.|.:..::....|:.||..:.|:||.......:.|..::.|....||.:.||
Mouse   188 EGIPLAQVA--AGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCG 250

  Fly  4303 SQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVA-CSDSGE 4366
            .:.:..|||||.|:|:|.|...:|||.||:....|::|..|.|.::..||.|..|.:| ...||.
Mouse   251 EEHTAVLTKSGGVFTFGAGSCGQLGHDSVNDEVNPRRVLELMGSEVTQIACGRQHTLALVPSSGL 315

  Fly  4367 VYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKH--------------IVK----------VTC-- 4405
            :|.:|...:||||.|....::.|..|......|              :||          |.|
Mouse   316 IYAFGCGAKGQLGTGHTCNVKCPSPVKGHWAAHSSQLSARADRFKYRVVKQIFSGGDQTFVLCST 380

  Fly  4406 -------------------------------------GSAHTL-----ALSTS----------QL 4418
                                                 .:|:|:     .||::          ::
Mouse   381 YENSSPAVDFRTVNQTHYTNLINDETIAVWRQKLTEHNNANTVNGVVQILSSAACWNGSFLEKKI 445

  Fly  4419 SERLRPLPN-PPLEYDLVRDLAPEALHAR--LIL---LHHFSELVCPCLAMLP----------IS 4467
            .|..:..|. |.::.:..|.|..:.:|::  :||   |:.|...:.|.|:..|          |.
Mouse   446 DEHFKTSPKIPGIDLNSTRILFEKLMHSQHSMILEQILNSFESCLIPQLSSSPPDVEAMRIYLIL 510

  Fly  4468 GDLSLGALKD-----VLVYNIKEAAFRKVIQTTMVRDK----------------QHGPVIELNR- 4510
            .:..|  |:|     .|...:..|..|.....:.|.|.                ..|.|:.|.|
Mouse   511 PEFPL--LQDSKYYITLTIPLAMAILRLETNPSKVLDNWWSQACPKYFMKLVTLYKGAVLYLLRG 573

  Fly  4511 ----------------------------IQVKRSR------NRCNGLAGI-----------DGMK 4530
                                        ::||...      ...:.|..|           .|||
Mouse   574 RKTFLIPVLFNNYMTATLKLLEKLYKVNLKVKHVEYDKFYIPEISSLVDIQEDYLMWFLHQSGMK 638

  Fly  4531 --------------------------------------SVFGQMVQKL-------PLLTQEALAL 4550
                                                  :|.|..:|.:       |||.:....:
Mouse   639 ARPSIMQDAVTLCSYPFIFDAQAKTKMLQTDAELQMQVAVNGANLQNVFMLLTLEPLLARSPFLV 703

  Fly  4551 PH-----------------------RVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLIN 4592
            .|                       :..||.|.||...|.||...|....:..||.|   |:.
Mouse   704 LHVRRNHLVGDALRELSIHSDIDLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKELLN---PIY-- 763

  Fly  4593 TPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTG---- 4653
                 |.....:|..||..:.:..::.|.|..:|:..|:|:...:.:.::....::::|..
Mouse   764 -----GMFTYYQDSNLLWFSDTCFVEHNWFHLIGITCGLAIYNSTVVDLHFPLALYKKLLNVKPS 823

  Fly  4654 ----EVLRPT------DLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTSSARGHEVPLSTRY 4708
                :.|.||      :|.:...:.:....|:.        ||.....:.....: ..:|...|.
Mouse   824 LEDLKELSPTEGRSLQELLDYPGEDIEETFCLN--------FTVCRESYGVIEQK-KLIPGGDRV 879

  Fly  4709 THISPRNRAE----YVRLALGFRLHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDI 4769
            . :...||.|    ||.......:||:   ..|...|..||....:|.||..|||:||:.|:.:.
Mouse   880 A-VCKDNRQEFVDAYVNYIFQISVHEW---YTAFSSGFLKVCGGKVLELFQPAELRAMMVGNSNY 940

  Fly  4770 PLGLLKSVATYKG-FDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQ 4833
            ....|:..|.|:| :..:...|..|||...||..:::..||.|:.|..|:|  |........::|
Mouse   941 DWEELEETAVYRGDYSSTHPTVKLFWETFHEFPLEKKKKFLLFLTGSDRIP--IYGMASLQIIIQ 1003

  Fly  4834 VLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
            .....  :.:||.::||:.||.:|:||.|.::..:|..|:
Mouse  1004 STATG--EEYLPVAHTCYNLLDLPKYSSKEIMKARLTQAL 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274	10/29 (34%)
		RCC1	4154..4203	CDD:278826	16/49 (33%)
		RCC1	4206..4257	CDD:278826	17/51 (33%)
		RCC1	4260..4309	CDD:278826	12/48 (25%)
		RCC1	4312..4360	CDD:278826	19/47 (40%)
		RCC1	4364..4413	CDD:278826	18/116 (16%)
		HECTc	4509..4880	CDD:238033	97/498 (19%)
		HECTc	4553..4878	CDD:214523	82/340 (24%)
Herc3	NP_001348895.1	ATS1	2..331	CDD:227511	111/339 (33%)
		RCC1	313..377	CDD:366085	14/63 (22%)
		HECTc	702..1048	CDD:238033	83/367 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820