DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Rcbtb1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001347539.1 Gene:Rcbtb1 / 71330 MGIID:1918580 Length:531 Species:Mus musculus


Alignment Length:364 Identity:112/364 - (30%)
Similarity:174/364 - (47%) Gaps:29/364 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly  3008 KVPTFS----QTISRLRPIHIAGGS--KSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLP 3066
            |.|.|:    |....:|...:.|.|  :::::...| :|:..|...:..||.|...:..:|.:|.
Mouse     6 KWPIFTLLSPQEAGSIRKACVFGTSANEAIYVTDND-EVFVFGLNYSNCLGTGDNQSTLVPKKLE 69

  Fly  3067 VLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKP-RLVEALRAKKIRDV 3130
            .|....:|.:: :..|.|.|..|.||.|::||.....:||:|.......| ::...|..|::.:|
Mouse    70 ALCGKKIKSLS-YGSGPHVLLTTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVIEV 133

  Fly  3131 ACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVT-ALAGRRVVQVACGSRDAQTLAL 3194
            ||||.||.|:::.|||:.||....|::|.|....|..|:.|| .|..:|||.:|||  ...::|:
Mouse   134 ACGSHHSMALAADGELFAWGYNNCGQVGSGSTANQPTPRKVTNCLHTKRVVNIACG--QTSSMAV 196

  Fly  3195 TEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGD 3259
            .:.|.|:.||....|:||.|.:....||..:..|.|:.|.||.||...:||||..|.::.||...
Mouse   197 LDSGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHGMCVNQIVCGYAHTLALTDEGLLYAWGANT 261

  Fly  3260 YYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALH----CLAVTDAGQVYAWGDNDHGQQGSGNT 3320
            |.:||.|...::..|..| .:...|||.:|  |.|    ..|.|..|.||.||      |..|.:
Mouse   262 YGQLGTGSKNNLLSPTQI-MVEKERVIEIA--ACHSTHTSAAKTQGGHVYMWG------QCRGQS 317

  Fly  3321 FVNKKPALVIGLDAVFVNRVACGSSHSIAWGLPNASSDE 3359
            .:..........|.||    ||..:.:::|.|.:...::
Mouse   318 VILPHLTHFCCTDDVF----ACFGTPAVSWRLLSVEHED 352

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826 13/50 (26%)
RCC1 3091..3140 CDD:278826 18/49 (37%)
RCC1 3144..3194 CDD:278826 19/50 (38%)
RCC1 3197..3246 CDD:278826 18/48 (38%)
RCC1 3250..3298 CDD:278826 15/51 (29%)
RCC1 3302..3350 CDD:278826 12/47 (26%)
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
Rcbtb1NP_001347539.1 RCC1 1 40..91 13/52 (25%)
ATS1 43..>316 CDD:227511 96/284 (34%)
RCC1 2 93..145 19/51 (37%)
RCC1 3 147..198 20/52 (38%)
RCC1 4 199..250 20/50 (40%)
RCC1 5 252..302 16/52 (31%)
RCC1 6 304..356 14/59 (24%)
BTB_POZ_RCBTB1_CLLD7 350..466 CDD:349662 0/3 (0%)
BACK_RCBTB1 466..531 CDD:350603
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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