DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Ubr5

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_006520242.1 Gene:Ubr5 / 70790 MGIID:1918040 Length:2800 Species:Mus musculus


Alignment Length:3024 Identity:550/3024 - (18%)
Similarity:919/3024 - (30%) Gaps:1118/3024 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  2362 GVLYRHQVALRRILKQRAPGSIYA---SPDEPDRSDAESQQPG-EQDQQLSSGSGQEPQLLIQCI 2422
            |.||...:|:      .:.|.:|.   |..||.|:   :|.|. ...:....|...|..:|:...
Mouse   375 GALYSELLAV------SSKGELYQWKWSESEPYRN---AQNPSLHHPRATFLGLTNEKIVLLSAN 430

  Fly  2423 LLRATQASPVKACYSYMDLATAALNCIQSLATQAHQELSEGGGVPPNGRALSSPPQPTMVHGVPV 2487
            .:|||.|:......:::|...:::........|.:.||        .|..:.|      :|...:
Mouse   431 SIRATVATENNKVATWVDETLSSVASKLEHTAQTYSEL--------QGERIVS------LHCCAL 481

  Fly  2488 YNVARKE--------------QKPSEQVEQKSKWPAAA------------TDAQL---------- 2516
            |..|:.|              :|..|:...|:|.|.::            |...|          
Mouse   482 YTCAQLENNLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGA 546

  Fly  2517 -----------IGQIME--------MGFTRRTVELALKQLSLQAEIMPT-PE---QIVQWILEHP 2558
                       :|.:||        ..|..|:.| :||.:...::.:.| ||   :.|:..:..|
Mouse   547 VAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPE-SLKSMEKASKTLETKPESKQEPVKTEMGPP 610

  Fly  2559 DVCANTIEEDTLPLASSAS-----------SHDPEADSDNECPSSNSTTSSSTSSDTVEGQPMAV 2612
            ...|:|. .|...:|||||           ..:.|..::.:.|...........:..| |:.:.|
Mouse   611 PSPASTC-SDASSIASSASMPYKRRRSTPAPREEEKVNEEQWPLREVVFVEDVKNVPV-GKVLKV 673

  Fly  2613 SGPAPPVKFESRKDFQT--------ADLYALYVRGLVRPGMTVRCCR-----DFEEIKQGDMGTV 2664
            .|....|||.......|        ||           |...::.||     :.:.:|.|  ||.
Mouse   674 DGAYVAVKFPGTSTNTTCQNSSGPDAD-----------PSSLLQDCRLLRIDELQVVKTG--GTP 725

  Fly  2665 LI-----------------------VDTEGLHDLNVQVDWRNHGSTYWVCFVHIELVEAAQTHHQ 2706
            .:                       ||::|:|.:.....|..:      |...:...:|.|.::.
Mouse   726 KVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGSWVRY------CVFDLATGKAEQENNF 784

  Fly  2707 PRPPPIAVGARVRLRTSSLRYGMLCPLRLGRSQGSSAI---GVVSSV--RSKQLTVDFPDQPAWQ 2766
            |              |||:.:       ||:.:.|.||   |..|.:  |....|: :|......
Mouse   785 P--------------TSSVAF-------LGQDERSVAIFTAGQESPIVLRDGNGTI-YPMAKDCM 827

  Fly  2767 GHINEVELVASQPTSATLPSLG---DSCSQMPPSDLIEDWSRCIRSLTVSSNEAAAKHLLNGSNQ 2828
            |.|.:.:.:...|.|    |||   .|...:|.:..|:..:..|  :.....:...:|:|.    
Mouse   828 GGIRDPDWLDLPPIS----SLGMGVHSLINLPANSTIKKKAAII--IMAVEKQTLMQHILR---- 882

  Fly  2829 PWQSCSSGPCRHWIRLELHDRILVHSLTLKVSPEDHSHMPSLLEIRVGDCVDSLKEYTWIPVPAG 2893
                |....||.:: :.|...:::         |.:..|..                |:|.....
Mouse   883 ----CDYEACRQYL-VNLEQAVVL---------EQNLQMLQ----------------TFISHRCD 917

  Fly  2894 ASRVLLMQQVPTYYPW------VEVVVKQCQNNGIQCKIHGIKFVGRRQQPDLQHILANAQFLAS 2952
            .:|.:|...|...:|.      .|...::.:.|....::..::            .:|||..:.|
Mouse   918 GNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE------------AIANAISVVS 970

  Fly  2953 EYSAGVGPGSTAG--------------------------AGAVSTSHEEAAAAPEQDLPCTVMVW 2991
            ..    |||:.||                          |||.|:.|::..:.|           
Mouse   971 SN----GPGNRAGSSNSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP----------- 1020

  Fly  2992 GLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKV-----YACGEGTNGRL 3051
                           :..|::......:.|               ||.:     .|.|..|....
Mouse  1021 ---------------IAPPSWVPDPPSMDP---------------DGDIDFILAPAVGSLTTAAT 1055

  Fly  3052 GLG---VTHNVPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTL 3113
            |.|   .|..:|.|...|.:.:...:|...|    ..|.|..|..|.                  
Mouse  1056 GSGQGPSTSTIPGPSTEPSVVESKDRKANAH----FILKLLCDSAVL------------------ 1098

  Fly  3114 DKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRR 3178
             :|.|.|.|.||..|.:   :...:|:|  |..|                    |..:|.|    
Mouse  1099 -QPYLRELLSAKDARGM---TPFMSAVS--GRAY--------------------PAAITIL---- 1133

  Fly  3179 VVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFS 3243
                    ..||.:|..|..|.....|...|.:...|:...|:|          :..:.|....|
Mouse  1134 --------ETAQKIAKAEVSASEKEEDVFMGMVCPSGTNPDDSP----------LYVLCCNDTCS 1180

  Fly  3244 LALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCL-AVTDAGQVYAW 3307
            .       .||            |.:|:.  |.|...|       ..|.|..| ..|:..:|...
Mouse  1181 F-------TWT------------GAEHIN--QDIFECR-------TCGLLESLCCCTECARVCHK 1217

  Fly  3308 GDNDHGQQGSGNTFVN-----KKPALVIG-----LDAVF-----------------------VNR 3339
            |.:...::.|...:.:     |...|:.|     ||.::                       |..
Mouse  1218 GHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLTATNLVTLPNSRGEHLLLFLVQT 1282

  Fly  3340 VACGSSHSIAWGLPNASSDEEKRGPVPFSS----------------------------------- 3369
            ||..:.....:..|....|..::...|..|                                   
Mouse  1283 VARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLEPPRFAQLALERVLQDWNALRSMIMFGS 1347

  Fly  3370 --TRDPLGGSS-LGIYEAETMQTLKQEAKPLNQSS----------------LSESLALE------ 3409
              .:|||..|| :|       ..|.:|...|||.|                .::.|.|:      
Mouse  1348 QENKDPLSASSRIG-------HLLPEEQVYLNQQSGTIRLDCFTHCLIVKCTADILLLDTLLGTL 1405

  Fly  3410 --------TPAARQAALGHVLRAM-SILQARQLIVAALTSHSKVN-------------FKERGAV 3452
                    ||..|:.|:...:|.: |:.:...::...:.|..|.|             |:.....
Mouse  1406 VKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMASSKKKNNFIPQPIGKCKRVFQALLPY 1470

  Fly  3453 GGEE-----DHLIGGPIMG-----APLQLAETIAQGGGEAPADATDAGLQEHSPEAAVDALTGGM 3507
            ..||     :.||....||     ||..||.|                        ::||:.|  
Mouse  1471 AVEELCNVAESLIVPVRMGIARPTAPFTLAST------------------------SIDAMQG-- 1509

  Fly  3508 SGGANTLPPLSAGPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEMLSH 3572
            |....::.||...|.|...|     |.|.|.||..:...:..|:|.|  ..:.....:|::::| 
Mouse  1510 SEELFSVEPLPPRPSSDQAS-----SSSQSQSSYIIRNPQQRRISQS--QPVRGRDEEQDDIVS- 1566

  Fly  3573 ISHCHGLDDFGGLLGE------------------------PEAKSLVELLKLAVCGRCGPPSTSQ 3613
             :....::...|:.||                        .|..|.:||..||         .::
Mouse  1567 -ADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGHHDEHDEDGSDMELDLLA---------AAE 1621

  Fly  3614 TIADTLISLGAGTPAVAAMLLETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDNVN-----VT 3673
            |.:|:                                          ||:|...||.:     ||
Mouse  1622 TESDS------------------------------------------ESNHSNQDNASGRRSVVT 1644

  Fly  3674 --------GVVRIPGAEMLRLEFDSQCSTEKRNDPLVIMDGTGRVLAMRSGREFAHWAPEIRVLG 3730
                    |...:|.   ...|.|||.:....:|              .|..:......|..:|.
Mouse  1645 AATAGSEAGASSVPA---FFSEDDSQSNDSSDSD--------------SSSSQSDDIEQETFMLD 1692

  Fly  3731 DELRWKFSSDSSVNG---------WGWRFWVHAIMPAATLGESGSDRAVLSQPSMALVMSLLDSR 3786
            :.|. :.::.|..||         |..|...|             .||..:.||.....:...:.
Mouse  1693 EPLE-RTTNSSHANGAAQAPRSMQWAVRNPQH-------------QRAASTAPSSTSTPAASSAG 1743

  Fly  3787 LAPRQPSVLLR----------LASALAACSQLGALTTAQRIWSLRKLHAVLLLEQAPRPQDPSLS 3841
            |....||.|.|          .|:||.|.:....||:|.   ||.:.:::::.:         :|
Mouse  1744 LIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSAS---SLARAYSIVIRQ---------IS 1796

  Fly  3842 TLLQPLIPELLRQYEY-EEPQVRGGIHLMHSDYFKTLAALACDMQ--LDAALPAT--------SS 3895
            .|: .|||    :|.: ...|:...:.|.:.|        |.::|  ::..|..|        .|
Mouse  1797 DLM-GLIP----KYNHLVYSQIPAAVKLTYQD--------AVNLQNYVEEKLIPTWNWMVSVMDS 1848

  Fly  3896 SSSSSAAPGAISSTGDV----HKWAWFKRYCIAVRVAQSLIRR-----TELPRAFCLEVRKKFAE 3951
            :.:......|::|.||.    |          .:..:|:..||     .|......||.|:: |.
Mouse  1849 TEAQLRYGSALASAGDPGHPNH----------PLHASQNSARRERMTAREEASLRTLEGRRR-AT 1902

  Fly  3952 MLPSSSSNSNANPGCQSPGASMLNSTTSLSSS---TVSNVSPPPGI------------------- 3994
            :|       :|..|..|.....||...||..|   ..|:|.|...:                   
Mouse  1903 LL-------SARQGMMSARGDFLNYALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKA 1960

  Fly  3995 TGEQPDLHCHAHQLESTSTLL-----HEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGW 4054
            ..:|..|.....:.:.|..||     :|| :..:...|......||.:.||        |.....
Mouse  1961 MNQQTTLDTPQLERKRTRELLELGIDNED-SEHENDDDTSQSATLNDKDDD--------SLPAET 2016

  Fly  4055 GHNH----RGQ----LGGLEGSRIKTPTPCEALSLL-RP--VQLAGGEQSLFAVTPDGKLFATGY 4108
            |.||    |..    ||.:..:..:.|. .||:.|. :|  :|....::.||. .|...|:::..
Mouse  2017 GQNHPFFRRSDSMTFLGCIPPNPFEVPL-AEAIPLADQPHLLQPNARKEDLFG-RPSQGLYSSSA 2079

  Fly  4109 GSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWG------------ 4161
            |||                         |.:...:..::||.:......||..            
Mouse  2080 GSG-------------------------KCIVEVTMDRNCLEVLPTKMSYAANLKNVMNMQNRQK 2119

  Fly  4162 -EGEDGKL----GHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITA-----------SGHVL 4210
             |||:..|    ...::.....|.:...|....:|:|....:....:|:           ..|.:
Mouse  2120 KEGEEQSLLAEEADSSKPGPSAPDVAAQLKSSLLAEIGLTESEGPPLTSFRPQCSFMGMVISHDM 2184

  Fly  4211 TWGKGR-----YGRL-----------------GHGDSEDQLRPKLVEALLGYRAIDIACG---SG 4250
            ..|:.|     :||:                 |....|.:.|.:: |.|...::.|::..   ..
Mouse  2185 LLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEVKESKFRREM-EKLRNQQSRDLSLEVKVDR 2248

  Fly  4251 DAQTL---------------CITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVE 4300
            |...|               |.|....|                ...|:.:|.|...|.||.:  
Mouse  2249 DRDLLIQQTMRQLNNHFGRRCATTPMAV----------------HRVKVTFKDEPGEGSGVAR-- 2295

  Fly  4301 CGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSG 4365
               .|..|:.:                             |.|..:|:     .:|.|:..::.|
Mouse  2296 ---SFYTAIAQ-----------------------------AFLSNEKL-----PNLDCIQNANKG 2323

  Fly  4366 -------EVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALS-TSQLSERL 4422
                   .:...|:.|..:         :|.|.:....|     :..||....... ..|||...
Mouse  2324 THTSLMQRLRNRGERDRER---------EREREMRRSSG-----LRAGSRRDRDRDFRRQLSIDT 2374

  Fly  4423 RPL-----PNPPLEYDLV---RDLAPEALHARLILLH-HFSELVCPCLAMLPISGDLSLGALKDV 4478
            ||.     .||..:.|.:   |....|.|:.|:..:. .|:..:...|..|..:..|.|.|.:|.
Mouse  2375 RPFRPASEGNPSDDPDPLPAHRQALGERLYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDS 2439

  Fly  4479 LVYNIKEAAFRKVIQTTMVRDKQHG--PVIEL------NRIQVKRSRNRCNGLAGIDGMKSVFGQ 4535
            |...:.||     ::..:...:::|  .:::|      .::|..|.|:                 
Mouse  2440 LRARVDEA-----MELIIAHGRENGADSILDLGLLDSSEKVQENRKRH----------------- 2482

  Fly  4536 MVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEM-CDELQNG--SVPLLINTPNGR 4597
                                              |.|.|:.:| .::..:|  :.||... |..|
Mouse  2483 ----------------------------------GSSRSVVDMDLEDTDDGDDNAPLFYQ-PGKR 2512

  Fly  4598 G----EAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRP 4658
            |    ..|.|.:.           ::|.||.:|.::|:.:.......|.|...|.:.|.|..:..
Mouse  2513 GFYTPRPGKNTEA-----------RLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNW 2566

  Fly  4659 TDLTEVD---RDYVAGLLCIRNMDDDPKLFTALELPFSTSSAR---GHEVPLSTRYTHI--SPRN 4715
            .|....|   .:.:..|:......|...:|:|::|.|:....:   |.:|.|.....:|  :|:|
Mouse  2567 HDFAFFDPVMYESLRQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQN 2631

  Fly  4716 RAEYVRLALGFRLHEFDEQ-VKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVAT 4779
            ..||||.....|:....|| :.|:|.|:..|:|...|...:|.:.:.:|.|..::.:.:|.|..:
Mouse  2632 VYEYVRKYAEHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTS 2696

  Fly  4780 YKGFDPSSA-----LVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNP 4839
            :......:|     ...|||.::|:.:..||...:.| |  |..|...|...|...:..:..:.|
Mouse  2697 FNDESGENAEKLLQFKRWFWSIVEKMSMTERQDLVYF-W--TSSPSLPASEEGFQPMPSITIRPP 2758

  Fly  4840 PDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
            .|..||.:.||...|.:|.||.|.:|.:||..||
Mouse  2759 DDQHLPTANTCISRLYVPLYSSKQILKQKLLLAI 2792

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585 13/76 (17%)
Cul7 2624..2699 CDD:288381 16/110 (15%)
APC10-HERC2 2762..2932 CDD:176485 27/178 (15%)
RCC1 3037..3088 CDD:278826 14/58 (24%)
RCC1 3091..3140 CDD:278826 9/48 (19%)
RCC1 3144..3194 CDD:278826 7/49 (14%)
RCC1 3197..3246 CDD:278826 8/48 (17%)
RCC1 3250..3298 CDD:278826 10/48 (21%)
RCC1 3302..3350 CDD:278826 11/80 (14%)
RCC1_2 4136..4166 CDD:290274 8/42 (19%)
RCC1 4154..4203 CDD:278826 10/65 (15%)
RCC1 4206..4257 CDD:278826 13/90 (14%)
RCC1 4260..4309 CDD:278826 8/48 (17%)
RCC1 4312..4360 CDD:278826 5/47 (11%)
RCC1 4364..4413 CDD:278826 8/55 (15%)
HECTc 4509..4880 CDD:238033 86/386 (22%)
HECTc 4553..4878 CDD:214523 83/342 (24%)
Ubr5XP_006520242.1 CUE_UBR5 184..230 CDD:270606
ZnF_UBR1 1177..1244 CDD:197698 16/94 (17%)
PolyA 2391..2454 CDD:197769 14/67 (21%)
HECTc 2469..2797 CDD:214523 86/390 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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