DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Smurf1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_006248944.1 Gene:Smurf1 / 690516 RGDID:1594738 Length:757 Species:Rattus norvegicus


Alignment Length:994 Identity:219/994 - (22%)
Similarity:340/994 - (34%) Gaps:329/994 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly  3962 ANPGCQSPGASMLNSTTSLSSSTVSNVS----PPP----GITGEQPDLHCHAHQLESTSTL---- 4014
            :|||.:..|:|:....|.|.:..::...    |.|    .:.|..   .||     ||.|:    
  Rat     2 SNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSG---QCH-----STDTVKNTL 58

  Fly  4015 ---LHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHN--HRGQLGGLEG------- 4067
               .::.:.|:....|                    :.||..|.|.  |:.|..|..|       
  Rat    59 DPKWNQHYDLYVGKTD--------------------SITISVWNHKKIHKKQGAGFLGCVRLLSN 103

  Fly  4068 --SRIKTPTPCEALSL--LRP--VQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPT 4126
              ||:| .|..:.|.|  |.|  .....|:..:...|.|            |:|.|||    :..
  Rat   104 AISRLK-DTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRD------------RIGGGGS----VVD 151

  Fly  4127 LLGSLQHVFVKKVAVNSG-GKHCLALTTEGEVYAWGEGEDGKLGHGN-----RMSYDRPKLVEHL 4185
            ..|.|::  ...|..:|| |:....|..|...|..|.|  ...|.||     ..|.|:..||:.|
  Rat   152 CRGLLEN--EGTVYEDSGPGRPLSCLMEEPAPYTDGTG--AAAGGGNCRFVESPSQDQRLLVQRL 212

  Fly  4186 NGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSG 4250
            ....|.    ||..:......||                    ..|:|.|   ||.......|  
  Rat   213 RNPEVR----GSLQTPQNRPHGH--------------------QSPELPE---GYEQRTTVQG-- 248

  Fly  4251 DAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAV 4315
              |...:.....|.:|.|.             ::|..:.::.|        |.:        ..:
  Rat   249 --QVYFLHTQTGVSTWHDP-------------RIPSPLGTIPG--------GDE--------AFL 282

  Fly  4316 YTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHC-----------VACSDSGEVYT 4369
            |     :|...||.|     .|:.:             .|::|           |..:.||.:|.
  Rat   283 Y-----EFLLQGHTS-----EPRDL-------------NSVNCDELGPLPPGWEVRSTVSGRIYF 324

  Fly  4370 WGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRP---------- 4424
            ...|:.       .|....|||      .||:...|           ||.|..:|          
  Rat   325 VDHNNR-------TTQFTDPRL------HHIMNHQC-----------QLKEPSQPLQLPSEGSVE 365

  Fly  4425 ---LPNPPLEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGDLSLGALKDVLVYNIKEA 4486
               ||....|.|||:.|.        :|.|..|       ...|.:|...:...::    .|.|.
  Rat   366 DEELPAQRYERDLVQKLK--------VLRHELS-------LQQPQAGHCRIEVSRE----EIFEE 411

  Fly  4487 AFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALP 4551
            ::|::::   :|.|.                                                |.
  Rat   412 SYRQIMK---MRPKD------------------------------------------------LK 425

  Fly  4552 HRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLL------INTPNGRGEAGANRDCFLLD 4610
            .|: .|||.||...|.||...|.:..:|.|:.|....|.      |.|.....::..|.|     
  Rat   426 KRL-MVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPD----- 484

  Fly  4611 PTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCI 4675
                   .::.|.|:|.:||:||..|..::.....|.::||.|:.::.:||..||.:....|:.|
  Rat   485 -------HLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWI 542

  Fly  4676 RNMDDDPKLFTALELPFSTS-SARG----HEVPLSTRYTHISPRNRAEYVRLALGFR-LHEFDEQ 4734
            ...|..|    .|:..|... :|.|    ||:..:.|...::..|:.|||||.:.:| :...:.|
  Rat   543 LENDITP----VLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQ 603

  Fly  4735 VKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEE 4799
            ..|::.|.:::||..||..|...||:.::.|...|.|...||....|.....|.:|.|||:.:|.
  Rat   604 FLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVET 668

  Fly  4800 FTNQERSLFLRFVWGRTRLPRTIADFRG----------RDFVLQVLEKNPPDHFLPESYTCFFLL 4854
            |..:.|:..|:||.|.||:|  :..|:.          |.|.:.:::.|..:  ||:::|||..:
  Rat   669 FDEERRARLLQFVTGSTRVP--LQGFKALQGSTGAAGPRLFTIHLIDANTDN--LPKAHTCFNRI 729

  Fly  4855 KMPRYSCKAVLLEKLKYAI 4873
            .:|.|.....|.|||..|:
  Rat   730 DIPPYESYEKLYEKLLTAV 748

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 9/30 (30%)
RCC1 4154..4203 CDD:278826 15/53 (28%)
RCC1 4206..4257 CDD:278826 9/50 (18%)
RCC1 4260..4309 CDD:278826 6/48 (13%)
RCC1 4312..4360 CDD:278826 8/58 (14%)
RCC1 4364..4413 CDD:278826 11/48 (23%)
HECTc 4509..4880 CDD:238033 100/387 (26%)
HECTc 4553..4878 CDD:214523 99/343 (29%)
Smurf1XP_006248944.1 C2_Smurf-like 14..138 CDD:176028 29/152 (19%)
WW 236..267 CDD:197736 9/50 (18%)
WW 307..339 CDD:197736 7/38 (18%)
HECTc 399..754 CDD:238033 105/426 (25%)
HECTc 423..754 CDD:214523 100/395 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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