DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Ube3b

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001137366.1 Gene:Ube3b / 687633 RGDID:1583074 Length:1070 Species:Rattus norvegicus


Alignment Length:509 Identity:130/509 - (25%)
Similarity:213/509 - (41%) Gaps:125/509 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  4429 PLEYDLVRDLAPEAL---------HARLILLHHFSELVCPCLAMLPISGDLSLGALKDVLVYNIK 4484
            |.::.|.:||.|..|         .|:|||||                       :..|:.:..:
  Rat   614 PEDHWLRKDLKPGVLFQELDKDRKRAQLILLH-----------------------IPHVVPHKNR 655

  Fly  4485 EAAFRKVIQTTMVRDKQHGPVIE-------LNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPL 4542
            ...||.::    :::|:...::|       :..|.::|||...:|.           :.:::|| 
  Rat   656 VLLFRNMV----IKEKEKLGLVETSSASPHVTHITIRRSRMLEDGY-----------EQLRQLP- 704

  Fly  4543 LTQEAL--ALPHRVWKVKFVGE-SVDDCG----GGYSESIAEMCDELQNGSVPLLINTPNGRGEA 4600
              |.|:  |:     :||||.: .||:.|    |.:.|.:.|:...:.:.::.|...|      :
  Rat   705 --QHAMKGAI-----RVKFVSDLGVDEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTT------S 756

  Fly  4601 GANRDCFLLDPTLSSVLQMN---MFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGE-----VLR 4657
            |..|    |.|:.:|.:..|   :|.|:|.::|.||..|..:.:..|.....|:.|.     ...
  Rat   757 GDER----LYPSPTSYIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQMLGHHHSVFYSS 817

  Fly  4658 PTDLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFS-TSSARG----HEVPLSTRYTHISPRNRA 4717
            ..:|..:|.::...|..|:..|.|   ...|.|..| .....|    ||:....:...::..|:.
  Rat   818 VDELPSLDSEFYKNLTSIKRYDGD---VADLGLTLSYDEDVMGQLVCHELVPGGKTIPVTDENKI 879

  Fly  4718 EYVRLALGFRLH-EFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCG-SPDIPL-GLLKSVAT 4779
            .|:.|...||:| :...|..|:..|...:|....:.:||..|||.::.| :.:|.| .|.|....
  Rat   880 SYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVY 944

  Fly  4780 YKGFDPSSALVTWFWEVM-EEFTNQERSLFLRFVWGRTRLP---------------------RTI 4822
            |.||..|..::.|.|::: .:||..||::||:||...:|.|                     :..
  Rat   945 YGGFHGSHRVIVWLWDILASDFTPGERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDT 1009

  Fly  4823 ADFRG---RDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
            .|..|   |.|.  .:.|..|...||.|.|||.|||:|.||.|:||.|||:|||
  Rat  1010 GDTLGSVLRGFF--TIRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAI 1061

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033 113/413 (27%)
HECTc 4553..4878 CDD:214523 103/367 (28%)
Ube3bNP_001137366.1 HECTc 684..1068 CDD:238033 113/412 (27%)
HECTc 709..1067 CDD:214523 104/373 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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