DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and Rcc1

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	XP_006239135.1	Gene:	Rcc1 / 682908	RGDID:	1592835	Length:	434	Species:	Rattus norvegicus

Alignment Length:	343	Identity:	100/343 - (29%)
Similarity:	162/343 - (47%)	Gaps:	37/343 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly  2988 VMVWGLNDKEQLG---GLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACG--EGT 3047
            |..:|.||:..||   .::||:: ||  .:...:.:.:.::.|......:::||:|:..|  ...
  Rat   101 VYSFGCNDEGALGRDTSVEGSEM-VP--GKVELQEKVVQVSAGDSHTAALTEDGRVFLWGSFRDN 162

  Fly  3048 NGRLGLGVTHNVPLPHQL-PVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLG----- 3106
            ||.:||    ..|:...: ||..|...:.|.|.||..|.:.||.||.:::.|.||.|:||
  Rat   163 NGVIGL----LEPMKKSMVPVQVQLDTQVVKVASGNDHLVMLTTDGDLYTLGCGEQGQLGRVPEL 223

  Fly  3107 ---HGNRTTLDK---PRLVEALRAK------KIRDVACGSSHSAAISSQGELYTWGLGEYGRLGH 3159
               .|.|..|::   ||.| .|:::      :.:|..||:..:.|||.:|.:|.:||..|.:||.
  Rat   224 FANRGGRQGLERLLVPRCV-LLKSRGTRGRVRFQDAFCGAYFTFAISREGHVYGFGLSNYHQLGT 287

  Fly  3160 GDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRG-GSEGSDTPH 3223
            ....:...|:.:|:........|........|:.:..:|..:|.|..::|:||.| |:|....|.
  Rat   288 PGTGSCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 352

  Fly  3224 EIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGG--LRGRRVI 3286
            .|.||..:.  .:.|||....|:::.|.|:.||.|..|:||.|.:.....|..:.|  |..|.|:
  Rat   353 LISRLPVVS--SVACGASVGYAVSKDGRVFAWGMGTNYQLGTGQEDDAWSPVEMTGKQLENREVL 415

  Fly  3287 HVAVGALH-CLAVTDAGQ 3303
            .|:.|..| .|.|.|..|
  Rat   416 TVSSGGQHTVLLVKDKTQ 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826	17/53 (32%)
		RCC1	3091..3140	CDD:278826	18/65 (28%)
		RCC1	3144..3194	CDD:278826	11/49 (22%)
		RCC1	3197..3246	CDD:278826	16/49 (33%)
		RCC1	3250..3298	CDD:278826	18/50 (36%)
		RCC1	3302..3350	CDD:278826	1/2 (50%)
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
Rcc1	XP_006239135.1	ATS1	19..432	CDD:227511	99/340 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820