DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and RPGR

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001030025.1 Gene:RPGR / 6103 HGNCID:10295 Length:1152 Species:Homo sapiens


Alignment Length:627 Identity:150/627 - (23%)
Similarity:243/627 - (38%) Gaps:194/627 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  2990 VWGLNDKEQLGGLKGSKVKVPTFSQTISRLRPIHI---AGGSKSLFIVSQDGKVYACGEGTNGRL 3051
            ::|.|:..|||....|.:..||   .:..|:|..:   |.|.....:.::.|.|||.|....|:|
Human    58 MFGSNNWGQLGLGSKSAISKPT---CVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQL 119

  Fly  3052 GLGVTHNVPLPHQLPVL-RQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDK 3115
            |||.|......|.:... .::.:|:::  :|...:.|||.||::|.||:..:|::|..|.:.:..
Human   120 GLGDTEERNTFHVISFFTSEHKIKQLS--AGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCV 182

  Fly  3116 PRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLG-----HGDNTTQLKPKLVTALA 3175
            |:.|..  .|.:..::||..|||.:::.||||.:|..|.|:||     .|::.|   |:||:.:.
Human   183 PQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRT---PQLVSEIP 242

  Fly  3176 GRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGA 3240
             .:|:|||||..  .|:.|||: ||:::|.|.||:|                  |:|....|   
Human   243 -EKVIQVACGGE--HTVVLTEN-AVYTFGLGQFGQL------------------GLGTFLFE--- 282

  Fly  3241 QFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVY 3305
                                          ..:|:.|..:|.:.:.:::.|..|...:||.|.:|
Human   283 ------------------------------TSEPKVIENIRDQTISYISCGENHTALITDIGLMY 317

  Fly  3306 AWGDNDHGQQGSG-----NTFVNKKPALVIGLDAVFVNRVACGSSH------------------- 3346
            .:||..||:.|.|     |.|:   |.|........|..||||..|                   
Human   318 TFGDGRHGKLGLGLENFTNHFI---PTLCSNFLRFIVKLVACGGCHMVVFAAPHRGVAKEIEFDE 379

  Fly  3347 ------SIAWGLPNAS----------------SDEEKRGPVPFSSTR--DPLGGSSLG------- 3380
                  |:|..||.:|                ..|.:|.|..||..|  .|:.| :||       
Human   380 INDTCLSVATFLPYSSLTSGNVLQRTLSARMRRRERERSPDSFSMRRTLPPIEG-TLGLSACFLP 443

  Fly  3381 ----------------IYEAETMQ---------TLKQEAKPLNQSSLSESLALETPAARQAALGH 3420
                            :.|.:.||         .:.:||: ::.||..|||...|....   :.|
Human   444 NSVFPRCSERNLQESVLSEQDLMQPEEPDYLLDEMTKEAE-IDNSSTVESLGETTDILN---MTH 504

  Fly  3421 VL------RAMSI----LQARQLIVAALTSHSKV-------------NFKERGAVGGEEDHLIGG 3462
            ::      :::.:    .|.:|..:..||..:.:             ..||..|.   :.|:..|
Human   505 IMSLNSNEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKAC---KQHVSQG 566

  Fly  3463 PIMGAPLQLAETIAQGGGEAP------ADATDAGLQEHSPEA 3498
            ..|..|....|..:....|.|      .|:...|::|...||
Human   567 IFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEA 608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826 14/51 (27%)
RCC1 3091..3140 CDD:278826 16/48 (33%)
RCC1 3144..3194 CDD:278826 21/54 (39%)
RCC1 3197..3246 CDD:278826 10/48 (21%)
RCC1 3250..3298 CDD:278826 5/47 (11%)
RCC1 3302..3350 CDD:278826 19/77 (25%)
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
RPGRNP_001030025.1 RCC1 <38..312 CDD:332518 84/318 (26%)
RCC1 314..360 CDD:306840 17/48 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.920

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