DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and ALS2

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_065970.2 Gene:ALS2 / 57679 HGNCID:443 Length:1657 Species:Homo sapiens


Alignment Length:1682 Identity:324/1682 - (19%)
Similarity:491/1682 - (29%) Gaps:730/1682 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly  2972 SHEEAAAAPEQDLPCTVMVWGLND----KEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLF 3032
            |..||..:.|:.|   |.:|....    .|:|.|..|..|              :..|.|.|...
Human     7 SSTEAEGSKERGL---VHIWQAGSFPITPERLPGWGGKTV--------------LQAALGVKHGV 54

  Fly  3033 IVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLR-----QYVVKKVAVHSGGKHALALTLDG 3092
            ::::||:||:.|. ...|.|     .|.:....|:|.     |||   :.|.:|..|:.|:|.:|
Human    55 LLTEDGEVYSFGT-LPWRSG-----PVEICPSSPILENALVGQYV---ITVATGSFHSGAVTDNG 110

  Fly  3093 KVFSWGEGEDGKLGHGNRTTLDKPRLV-----EA--LRAKKIRDVACGSSHSAAISSQGELYTWG 3150
            ..:.|||...|:....|:..:.:|..|     ||  |.|.:|..:|||..|:.|:|...|::.||
Human   111 VAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWG 175

  Fly  3151 LG-EYGRLGHGDNTTQL---KPKLVTALAGRRVVQVACG------------SRDAQ--------- 3190
            .| :.|.:     ||..   ||:.|..||||.|:|||||            |:|.:         
Human   176 TGCQLGLI-----TTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQC 235

  Fly  3191 -----TLALTEDGAVFSWGDGDFGKLG-------------------------------------- 3212
                 |:...||..:.|  |.....||                                      
Human   236 SQLLITMTDKEDHVIIS--DSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVAND 298

  Fly  3213 -----------------------------------------------------------RGGSEG 3218
                                                                       |..||.
Human   299 QSVATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVREDSEH 363

  Fly  3219 SDTPHEIERL---------------------------SGIGV----------------------V 3234
            .:.|...:.|                           |.:||                      .
Human   364 GEKPVPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKKVMNFYSTT 428

  Fly  3235 QIECGAQFS-------------------------------------------------------- 3243
            ..|.|||..                                                        
Human   429 PCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSRRLSLPGLLSQVSP 493

  Fly  3244 ---------------LALTRAG-----------EVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRG 3282
                           |..|.:|           ||||||||...:||||......:|..:..|.|
Human   494 RLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDG 558

  Fly  3283 RRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAVFVNRVACGSSHS 3347
            :.|||:..|..|.||:|...|||:||.|..||.|..: |....|            |:|..||.:
Human   559 KEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD-FPTTVP------------RLAKISSEN 610

  Fly  3348 IAWGLPNASSD--------EEKRGPVPFSSTRDPLGGSSLGIYEAETMQTLKQEAKPLNQSSLSE 3404
            ..|.:. |..|        |:.:..:.:|..:||..|.:|                |.|.|    
Human   611 GVWSIA-AGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNL----------------PENHS---- 654

  Fly  3405 SLALETPAARQAALGHVLRAMSILQARQLIVAALTSHSKVNFKERGAVGGEEDH--LIGGPIMGA 3467
              ..:||                         .|.|.||:.:..| ...|::.:  |:...|||.
Human   655 --GSKTP-------------------------VLLSCSKLGYISR-VTAGKDSYLALVDKNIMGY 691

  Fly  3468 PLQLAETIAQGGGEAPADATDAGLQEHSPEAAVDALTGGMSGGANTLPPLSAGPLSAFQSLTGSL 3532
            ...|.| :|.......:..:|...|...|..:::.|      |..|...|.....|.|..|...:
Human   692 IASLHE-LATTERRFYSKLSDIKSQILRPLLSLENL------GTTTTVQLLQEVASRFSKLCYLI 749

  Fly  3533 SMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEMLSHISHCHGLDDF---GG--LLGEP--- 3589
            ...|:..||.|    |....|.::.::..:....:   |:..:|..:.:|   ||  ||.:|   
Human   750 GQHGASLSSFL----HGVKEARSLVILKHSSLFLD---SYTEYCTSITNFLVMGGFQLLAKPAID 807

  Fly  3590 -----------------EAKSLVE-------------------LLKLAVCGRCGPPSTSQTIADT 3618
                             |...|:|                   |||||.|.....|. .|.:.|:
Human   808 FLNKNQELLQDLSEVNDENTQLMEILNTLFFLPIRRLHNYAKVLLKLATCFEVASPE-YQKLQDS 871

  Fly  3619 LISLGAGTPAVAAMLLETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDNVNVTGVVR-IPGAE 3682
                            .:|..     |.:.| ||:..|    |:.:       ..|..: .||..
Human   872 ----------------SSCYE-----CLALH-LGRKRK----EAEY-------TLGFWKTFPGKM 903

  Fly  3683 MLRLEFDSQCSTEKRNDPLVIMDGTGRVLAMR-SGREFAHWAPEIRVLGDELRWKFSSDSSVNGW 3746
            .     ||....|:|    ::.:.:.|.|::: :||...:|            :...:|:.|:. 
Human   904 T-----DSLRKPERR----LLCESSNRALSLQHAGRFSVNW------------FILFNDALVHA- 946

  Fly  3747 GWRFWVHAIMPAATL-GESGSDRA--------VLSQPSMALVMSLLDSRLAPRQPSVLLRLAS-- 3800
              :|..|.:.|.||| .|..|:.|        ...:....|:.|      .|::.:..||..|  
Human   947 --QFSTHHVFPLATLWAEPLSEEAGGVNGLKITTPEEQFTLISS------TPQEKTKWLRAISQA 1003

  Fly  3801 ---ALAACSQL---GALTTAQRIWSLRKLHAVLLLEQAPRPQDPSLSTLLQPLIPELLRQYEYEE 3859
               ||...|.|   |:.::.||                   |:|.:|        ...:...|::
Human  1004 VDQALRGMSDLPPYGSGSSVQR-------------------QEPPIS--------RSAKYTFYKD 1041

  Fly  3860 PQVRGGIHLMHSDYFKTLAALACDMQLDAALPATSSSSSSSAAPGAISSTGDVHKWAWFKRYCIA 3924
            |:::                           .||......|..|..    ..|.||...|.|   
Human  1042 PRLK---------------------------DATYDGRWLSGKPHG----RGVLKWPDGKMY--- 1072

  Fly  3925 VRVAQSLIRRTELPRAFCLEVRKKFAEMLPSSSSNSNAN------------------------PG 3965
                 |.:.|..|...:. |.|      :|:.:.|...:                        .|
Human  1073 -----SGMFRNGLEDGYG-EYR------IPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEG 1125

  Fly  3966 C----QSPGASMLNSTTSLSSSTVS--------------------------------NVSPPPGI 3994
            |    ...|..:|.| ..|:||:.|                                :|....|:
Human  1126 CFQDNMRHGHGLLRS-GKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGV 1189

  Fly  3995 TGEQPDLH----CHAHQLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWG 4055
            ...|..|:    .|.:::.....||.||.|:::....           |||.||..|..|:.. |
Human  1190 VVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFS-----------DDWTLSGKGTLTMPN-G 1242

  Fly  4056 HNHRGQLGGLEGSRIK-TPTPCEALSLLRPVQLAGGEQSLFAVTPD-GKLFATGYGSGGRLGVGG 4118
            ....|...|..||.|| |.|      ..:|        ||:....| .|:|.    ..|.|.|..
Human  1243 DYIEGYFSGEWGSGIKITGT------YFKP--------SLYESDKDRPKVFR----KLGNLAVPA 1289

  Fly  4119 SDSWAIPTLLGSLQHVF---VKKVAVNSGGKHCLALTTEGEVY-AWGEGEDGKLGHGNRMSYDRP 4179
            .:.|         :.||   .:::.....|        :|||: || :.....|....|...|.|
Human  1290 DEKW---------KAVFDECWRQLGCEGPG--------QGEVWKAW-DNIAVALTTSRRQHRDSP 1336

  Fly  4180 KLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEA 4236
            :::......::..:.....|..|.:.                  :..|.:|..|::|
Human  1337 EILSRSQTQTLESLEFIPQHVGAFSV------------------EKYDDIRKYLIKA 1375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826 16/55 (29%)
RCC1 3091..3140 CDD:278826 17/55 (31%)
RCC1 3144..3194 CDD:278826 23/79 (29%)
RCC1 3197..3246 CDD:278826 18/265 (7%)
RCC1 3250..3298 CDD:278826 22/58 (38%)
RCC1 3302..3350 CDD:278826 15/47 (32%)
RCC1_2 4136..4166 CDD:290274 6/30 (20%)
RCC1 4154..4203 CDD:278826 10/49 (20%)
RCC1 4206..4257 CDD:278826 4/31 (13%)
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
ALS2NP_065970.2 RCC1 1. /evidence=ECO:0000305 59..108 17/57 (30%)
RCC1_2 93..122 CDD:290274 10/31 (32%)
RCC1 2. /evidence=ECO:0000305 109..167 18/57 (32%)
RCC1 109..165 CDD:278826 17/55 (31%)
RCC1 3. /evidence=ECO:0000305 169..218 20/53 (38%)
RCC1 170..216 CDD:278826 20/50 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 432..480 3/47 (6%)
RCC1 4. /evidence=ECO:0000305 525..576 22/50 (44%)
RCC1 527..574 CDD:278826 21/46 (46%)
RCC1 5. /evidence=ECO:0000305 578..627 18/62 (29%)
RCC1 579..625 CDD:278826 18/59 (31%)
RhoGEF 695..879 CDD:295373 41/219 (19%)
PH_alsin 905..1010 CDD:241423 28/129 (22%)
PH 926..1004 CDD:278594 20/98 (20%)
COG4642 1049..1188 CDD:226989 24/158 (15%)
MORN 1 1049..1071 5/25 (20%)
MORN 1049..1069 CDD:280628 5/23 (22%)
MORN 2 1072..1094 7/36 (19%)
MORN 3 1100..1122 0/21 (0%)
MORN 1100..1120 CDD:280628 0/19 (0%)
MORN 4 1123..1145 6/22 (27%)
MORN 5 1151..1173 0/21 (0%)
MORN 6 1175..1197 3/21 (14%)
MORN 7 1198..1220 5/21 (24%)
MORN 8 1221..1244 8/34 (24%)
VPS9 1554..1653 CDD:280383
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5184
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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