DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and HECW2

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_006712709.1 Gene:HECW2 / 57520 HGNCID:29853 Length:1579 Species:Homo sapiens


Alignment Length:1850 Identity:351/1850 - (18%)
Similarity:578/1850 - (31%) Gaps:666/1850 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly  3385 ETMQTLKQEAKPLNQSSLSESLALE--------TPAARQAALGHVLRAMSILQARQLIV------ 3435
            |.:|:|..      |||:.|::.|:        ..:..:::|...:...::.||:.||:      
Human    26 ENLQSLAA------QSSMPENMTLQRANSDTDLVTSESRSSLTASMYEYTLGQAQNLIIFWDIKE 84

  Fly  3436 ----------AALTSHSKVNF---KERGAVGGEEDHLI----GGPIMGAP-LQLAETIAQGGGEA 3482
                      ..:..:|..||   |.||..|.::..::    .||....| :::......|...|
Human    85 EVDPSDWIGLYHIDENSPANFWDSKNRGVTGTQKGQIVWRIEPGPYFMEPEIKICFKYYHGISGA 149

  Fly  3483 PADATDAGLQEHSPEAAVDALTGGMSGGAN-----------TLPPLSA----------------- 3519
             ..||...:...:|...:.|  .||.|||:           ||..|.|                 
Human   150 -LRATTPCITVKNPAVMMGA--EGMEGGASGNLHSRKLVSFTLSDLRAVGLKKGMFFNPDPYLKM 211

  Fly  3520 ----GPLSAFQSLT--GSLSMSGSLSSSALP---QHKHS-------------------------- 3549
                |..|:|.:..  |....|..:|::..|   :.|:|                          
Human   212 SIQPGKKSSFPTCAHHGQERRSTIISNTTNPIWHREKYSFFALLTDVLEIEIKDKFAKSRPIIKR 276

  Fly  3550 -----------------------------RMSASAMS-----VMAATMTQQEEML-SH------- 3572
                                         |:.|..:|     .:..|.:..|||| ||       
Human   277 FLGKLTIPVQRLLERQAIGDQMLSYNLGRRLPADHVSGYLQFKVEVTSSVHEEMLFSHSDASPEA 341

  Fly  3573 ISHCHGLDDFGGLLGEP-----------EAKSLVELLKLAVCGRCGPPSTSQTIADTLISLGAGT 3626
            :....|::...|.||.|           :::         ||.. ||.| ..:.||       ||
Human   342 VGTILGVNSVNGDLGSPSDDEDMPGSHHDSQ---------VCSN-GPVS-EDSAAD-------GT 388

  Fly  3627 PAVAAMLLETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDNVNVTGVVRIPGAEMLRLEFDSQ 3691
            |..:.....|...:.|:| ||.......|:. .|:|.:.|:|.:...|..| ||.        :.
Human   389 PKHSFRTSSTLEIDTEEL-TSTSSRTSPPRG-RQDSLNDYLDAIEHNGHSR-PGT--------AT 442

  Fly  3692 CSTEKRNDPLVIMDGTGRVLAMRSGREFAHWAPEIRVLG--DELRWKFSSDSSVNGWGWRFWVHA 3754
            ||.                                |.:|  .:||..|.:|:.:|         |
Human   443 CSE--------------------------------RSMGASPKLRSSFPTDTRLN---------A 466

  Fly  3755 IMPAATLGESGSDRAVLSQPSMALVMSLLDSRLAPRQPSVLLRLASALAACSQLGALTTAQRIWS 3819
            ::...:..|....:..|..||                                           |
Human   467 MLHIDSDEEDHEFQQDLGYPS-------------------------------------------S 488

  Fly  3820 LRKLHAVLLLEQAPRPQDPSLSTLLQPLIPELLRQYEYEEPQVRGGIHLMH-----SDYFKTLAA 3879
            |.:...:::..:|.|..|.||::           |.:.|:..|.......|     .|..:.|..
Human   489 LEEEGGLIMFSRASRADDGSLTS-----------QTKLEDNPVENEEASTHEAASFEDKPENLPE 542

  Fly  3880 LACDMQLDAALPATSSSSSSSAAP------------------------GAISSTGDVHKWAWFKR 3920
            ||     :::|||..:.......|                        ||.:.|.|....:  :|
Human   543 LA-----ESSLPAGPAPEEGEGGPEPQPSADQGSAELCGSQEVDQPTSGADTGTSDASGGS--RR 600

  Fly  3921 YCIAVRVAQSLIRRTELPRAFCLEVRKKFAEMLPS--SSSNSNANPGCQSPGASMLNSTTSLSSS 3983
               ||...:||.:.:|                 ||  ||....::|.               .:.
Human   601 ---AVSETESLDQGSE-----------------PSQVSSETEPSDPA---------------RTE 630

  Fly  3984 TVSNVSPPPGITGEQPDLHCHAHQL-ESTSTLLHEDHTLFQAPHDAQLLQ---WLNRRPDDWALS 4044
            :||..|..|  .||. ||.|..... ||.:|.|....|...:...|:..:   :.::..:|.|.:
Human   631 SVSEASTRP--EGES-DLECADSSCNESVTTQLSSVDTRCSSLESARFPETPAFSSQEEEDGACA 692

  Fly  4045 WGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEALSLLRP-VQLAGGEQ----SLFAVTPDGKLF 4104
            ....|:            |..|||:   .:.|.|.||  | ||:..||.    :..|..||.:..
Human   693 AEPTSS------------GPAEGSQ---ESVCTAGSL--PVVQVPSGEDEGPGAESATVPDQEEL 740

  Fly  4105 ATGYGSGGRLGVGGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEG----ED 4165
            ...:...|.|....:.:.:.|...||                       .||.....||    |:
Human   741 GEVWQRRGSLEGAAAAAESPPQEEGS-----------------------AGEAQGTCEGATAQEE 782

  Fly  4166 GKLG----HGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAITASGHVL---------TWGK--- 4214
            |..|    :|::.....|.:.:.::.....|.|......|.|.:.|.:.         ||.:   
Human   783 GATGGSQANGHQPLRSLPSVRQDVSRYQRVDEALPPNWEARIDSHGRIFYVDHVNRTTTWQRPTA 847

  Fly  4215 --------------------GRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITD 4259
                                .||..:....:.:  ||:     ....|||   |:|:        
Human   848 PPAPQVLQRSNSIQQMEQLNRRYQSIRRTMTNE--RPE-----ENTNAID---GAGE-------- 894

  Fly  4260 DDNVWSWGDGDYGKLGRGGSDGCKLPY-----KIESLAGLGVVKVECGSQFSVALTKSGAVY--- 4316
                    :.|:.:..........||:     :|..|.....||.....:|...|..:.:.|   
Human   895 --------EADFHQASADFRRENILPHSTSRSRITLLLQSPPVKFLISPEFFTVLHSNPSAYRMF 951

  Fly  4317 ----------TWGKGDFHRLGHGSVDHVRRPKKVAALQG------KKIISIATG--SLHCVACSD 4363
                      |..:.|.|        |..|.:....|.|      .|.:.:..|  ..|    ..
Human   952 TNNTCLKHMITKVRRDTH--------HFERYQHNRDLVGFLNMFANKQLELPRGWEMKH----DH 1004

  Fly  4364 SGEVYTWGDNDEGQLGDGTVTAIQRPRL--------VAALQGKHIVKVTCGSAHTLALSTSQLSE 4420
            .|:.:....|..      |.|.|. |||        .|.:..:|:.:....||       .::.|
Human  1005 QGKAFFVDHNSR------TTTFID-PRLPLQSSRPTSALVHRQHLTRQRSHSA-------GEVGE 1055

  Fly  4421 RLR-----PLPNPPLEYDLV-----RDLAPEALHARLILL--------------------HHFSE 4455
            ..|     .||.|...::.|     :|:.|.|.:.:::..                    |...|
Human  1056 DSRHAGPPVLPRPSSTFNTVSRPQYQDMVPVAYNDKIVAFLRQPNIFEILQERQPDLTRNHSLRE 1120

  Fly  4456 LV-------CPCLAMLPISGDLSLGALKDVLVYNIKEAAF------RKVIQTTMVRDKQHGPVIE 4507
            .:       .|.|..|....||       |::.::.|...      ..::..:..:..:..||  
Human  1121 KIQFIRTEGTPGLVRLSSDADL-------VMLLSLFEEEIMSYVPPHALLHPSYCQSPRGSPV-- 1176

  Fly  4508 LNRIQVKRSRNRCNGLAGIDGMKSV---------------FGQMVQKLPL------LTQEAL--- 4548
             :..|......|.|..|.....:..               :||...||.|      |.::|.   
Human  1177 -SSPQNSPGTQRANARAPAPYKRDFEAKLRNFYRKLETKGYGQGPGKLKLIIRRDHLLEDAFNQI 1240

  Fly  4549 ------ALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCF 4607
                  .|......|.||||...|..|...|....:..|        |.|...|..|..|| |.:
Human  1241 MGYSRKDLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRE--------LFNPYYGLFEYSAN-DTY 1296

  Fly  4608 LLDPTLSSVLQMN---MFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYV 4669
            .:..:..|....|   .|||.|.::|:|:.....|......|.::.|...:...:||..:|.::.
Human  1297 TVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRILCDLSDLEYLDEEFH 1361

  Fly  4670 AGLLCIRNMDDDPKL---FTALELPFSTSSAR-----GHEVPLSTRYTHISPRNRAEYVRLALGF 4726
            ..|..:::.|....|   ||..|..|...:.|     |..:|       ::.:|:.||:...:.:
Human  1362 QSLQWMKDNDIHDILDLTFTVNEEVFGQITERELKPGGANIP-------VTEKNKKEYIERMVKW 1419

  Fly  4727 RLHE-FDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYK-GFDPSSAL 4789
            |:.. ..:|.:::..|..:|:...|:|:|.|.||:.::.|:.:|.|...::...|: |:..:..:
Human  1420 RIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIV 1484

  Fly  4790 VTWFWEVMEEFTNQERSLFLRFVWGRTRLP-RTIADFRGRDFVLQVLEKNPPDHF---------- 4843
            :.|||..:|.|.|::|...|:||.|.:.:| ...|..||         .|.|..|          
Human  1485 IRWFWAAVERFNNEQRLRLLQFVTGTSSIPYEGFASLRG---------SNGPRRFCVEKWGKITA 1540

  Fly  4844 LPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
            ||.::|||..|.:|.|...::|.|||..|:
Human  1541 LPRAHTCFNRLDLPPYPSFSMLYEKLLTAV 1570

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 5/33 (15%)
RCC1 4154..4203 CDD:278826 12/56 (21%)
RCC1 4206..4257 CDD:278826 12/82 (15%)
RCC1 4260..4309 CDD:278826 8/53 (15%)
RCC1 4312..4360 CDD:278826 11/68 (16%)
RCC1 4364..4413 CDD:278826 12/56 (21%)
HECTc 4509..4880 CDD:238033 101/418 (24%)
HECTc 4553..4878 CDD:214523 89/344 (26%)
HECW2XP_006712709.1 HECW_N 45..164 CDD:318711 20/119 (17%)
C2_NEDL1-like 185..321 CDD:176073 16/135 (12%)
NESP55 <471..638 CDD:115071 41/262 (16%)
PHA03169 591..>801 CDD:223003 60/289 (21%)
WW 816..845 CDD:306827 5/28 (18%)
WW 994..1023 CDD:306827 7/39 (18%)
HECTc 1223..1577 CDD:238033 94/372 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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