| Sequence 1: | NP_608388.2 | Gene: | HERC2 / 33035 | FlyBaseID: | FBgn0031107 | Length: | 4912 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_065162.1 | Gene: | SMURF1 / 57154 | HGNCID: | 16807 | Length: | 757 | Species: | Homo sapiens |
| Alignment Length: | 1010 | Identity: | 218/1010 - (21%) |
|---|---|---|---|
| Similarity: | 339/1010 - (33%) | Gaps: | 361/1010 - (35%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 3962 ANPGCQSPGASMLNSTTSLSSSTVSNVS----PPP----GITGEQPDLHCHAHQLESTSTL---- 4014
Fly 4015 ---LHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHN--HRGQLGGLEG------- 4067
Fly 4068 --SRIKTPTPCEALSL--LRP--VQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPT 4126
Fly 4127 LLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVA 4191
Fly 4192 DIACGSAHSAAIT-ASGHVLTWGKGRY------------GRLGHGDSEDQLR-----------PK 4232
Fly 4233 LVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVV 4297
Fly 4298 KVECGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHC---- 4358
Fly 4359 -------VACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTS 4416
Fly 4417 QLSERLRPLPNPP-------------LEYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISG 4468
Fly 4469 DLSLGALKDVLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVF 4533
Fly 4534 GQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLL-INTPNGR 4597
Fly 4598 GEAGANRDCFLLDPTLSSVL---QMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPT 4659
Fly 4660 DLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTS-SARG----HEVPLSTRYTHISPRNRAEY 4719
Fly 4720 VRLALGFR-LHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGF 4783
Fly 4784 DPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRG----------RDFVLQVLEKN 4838
Fly 4839 PPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| HERC2 | NP_608388.2 | RCC1 | 638..683 | CDD:278826 | |
| RCC1 | 687..737 | CDD:278826 | |||
| RCC1 | 740..787 | CDD:278826 | |||
| RCC1 | 790..841 | CDD:278826 | |||
| RCC1_2 | 828..857 | CDD:290274 | |||
| Cyt-b5 | 1290..1363 | CDD:278597 | |||
| MIB_HERC2 | 1928..1987 | CDD:284184 | |||
| UBA_HERC2 | 2515..2559 | CDD:270585 | |||
| Cul7 | 2624..2699 | CDD:288381 | |||
| APC10-HERC2 | 2762..2932 | CDD:176485 | |||
| RCC1 | 3037..3088 | CDD:278826 | |||
| RCC1 | 3091..3140 | CDD:278826 | |||
| RCC1 | 3144..3194 | CDD:278826 | |||
| RCC1 | 3197..3246 | CDD:278826 | |||
| RCC1 | 3250..3298 | CDD:278826 | |||
| RCC1 | 3302..3350 | CDD:278826 | |||
| RCC1_2 | 4136..4166 | CDD:290274 | 8/29 (28%) | ||
| RCC1 | 4154..4203 | CDD:278826 | 11/48 (23%) | ||
| RCC1 | 4206..4257 | CDD:278826 | 14/73 (19%) | ||
| RCC1 | 4260..4309 | CDD:278826 | 6/48 (13%) | ||
| RCC1 | 4312..4360 | CDD:278826 | 8/58 (14%) | ||
| RCC1 | 4364..4413 | CDD:278826 | 11/48 (23%) | ||
| HECTc | 4509..4880 | CDD:238033 | 100/385 (26%) | ||
| HECTc | 4553..4878 | CDD:214523 | 99/341 (29%) | ||
| SMURF1 | NP_065162.1 | C2_Smurf-like | 14..138 | CDD:176028 | 29/152 (19%) |
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 193..237 | 7/43 (16%) | |||
| WW | 236..267 | CDD:197736 | 9/54 (17%) | ||
| WW | 307..339 | CDD:197736 | 7/38 (18%) | ||
| HECTc | 399..754 | CDD:238033 | 105/424 (25%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_COG5021 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.900 | |||||