DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and plekha7a

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001129715.1	Gene:	plekha7a / 571486	ZFINID:	ZDB-GENE-050419-75	Length:	1197	Species:	Danio rerio

Alignment Length:	722	Identity:	148/722 - (20%)
Similarity:	230/722 - (31%)	Gaps:	236/722 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1116 EEREQQHQEPSTSPSLSLLHRFQRLLLSHI-HQAQPEE----ETTGAEALLLQ-----YMHALIP 1170
            |:|......||.||     ||.:....:.| .::.|..    .|..|.:|..:     |||
Zfish   579 EDRPIVEVPPSNSP-----HRLRSYKSATIERRSMPPSAYITHTVSAPSLRGKTADDTYMH---- 634

  Fly  1171 ACVATLQKAHELALQCREPGENSFGQMVGHLGRVLQADI---------SDALLNELLVGLLLLKR 1226
                 |:|..|. |..:..|..:.........:|.::|:         .|.:|.||...|..||.
Zfish   635 -----LKKGLEY-LDLKVSGTEALKGRPAKPVKVAESDVDVTLSRLCEQDKILQELEFRLSGLKD 693

  Fly  1227 DRPQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGWPGIICRGGPKGGPPPADPETHYV 1291
            |:.:             |..|||..::.:.:                   .|..|...|...:..
Zfish   694 DKDK-------------LESVLDVSHQQMEQ-------------------YKDQPSHTDKIAYQQ 726

  Fly  1292 R---------RADMENLLLDGSRCIILAGYVCDLSGYNCESETLRSVLDSGLGKDLTAEMSSQVH 1347
            |         |||:..:..:..|.      ..|.||.....|.||.||.:.:....:.:..:|:.
Zfish   727 RLLQEDLVHIRADISRVSTEMERA------WDDYSGMEQSVEQLRDVLQTQMTLCTSPQEKNQLK 785

  Fly  1348 RT--AMEHILEHHKLGKYMVQASTEEK-----SSAPGPSRLTHFSSECALAQLLGLVANLMCSGP 1405
            |.  .||.::..        .:||:|.     .|...|.|           :|:..|........
Zfish   786 RELWRMEDVMTG--------LSSTKETFKITVDSVKNPER-----------KLVPSVIESTVPSR 831

  Fly  1406 ALQPAELQCRQLDKSSLLSGGLQLLQPSNPFDEEKGEARSSHSCHS-TAGNTPTELP-------- 1461
            .:.|:..:.|. .:.||.|..|.|     |.|.|  :.|:.|...: ...:.|...|
Zfish   832 CMTPSAAEVRS-PQRSLTSSPLSL-----PLDNE--DLRNRHPVPNWEEDDAPPRPPLPLLYDED 888

  Fly  1462 -----PPLPMQ----------------------QQLAPGRGKSQLQLRADAFISGLAEARVSEP- 1498
                 ||||.:                      ::.:...|..:|:||          :.:|||
Zfish   889 TPPVVPPLPKETSVIRHTSVRGLKRQSDERKRDRESSYSNGDYRLELR----------SYLSEPE 943

  Fly  1499 -PVAA---------WLALTERYCKAHNLMWHQ------------EFAT-EHPVQELERLLSAVLI 1540
             ||:|         :|.|..|.....:...:|            |.:| |.|...||||.|..
Zfish   944 LPVSAHGADHVDPGYLTLQRRGLSGSSSRINQYGVASCSLRRDLELSTMERPKSALERLCSGE-- 1006

  Fly  1541 RHQYLGGLVLNALETEVPPPRQLGEIIRLVHQAKWSVVRTRQQLNRSYKEVCAPILERLRFLLY- 1604
                      ..||.:..|.|     :|:         ...:||.|..:...|.:.||.|.|..
Zfish  1007 ----------PQLEQQSQPQR-----VRM---------SVEEQLERMKRHQRALVRERKRNLSQG 1047

  Fly  1605 -------EVRPAISPQQRGLRRLPILQRPPRFKMLVRRLLQELRSSRQPAKPE-DLLNASIQQEQ 1661
                   ..||..|.....|...|  .||...:.|..|....:.|..:|...| |:.......::
Zfish  1048 ERHHSRASTRPVNSDPGSALFVEP--HRPASDEWLTVRARPVMESELEPLDFEFDITRELSTPQK 1110

  Fly  1662 EKKPQSMPKQELEEQ---EEEETLLRR-------LNERQIHGEGELDPALMQDIVDFALQDSCDV 1716
            ...||.:...|.:|.   ||:||..|.       |::..:....::|   ..|: |.|||....:
Zfish  1111 VWIPQRLIDDESDEDPSPEEKETRSRTVAKIKTLLSKSSMRSSEQMD---FSDL-DLALQQQERI 1171

  Fly  1717 ETARRAM 1723
            .:..||:
Zfish  1172 MSVPRAL 1178

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597	17/83 (20%)
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
plekha7a	NP_001129715.1	WW	55..84	CDD:278809
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..148
		PH_PEPP1_2_3	153..256	CDD:270068
		PH	159..255	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..384
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..467
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..577
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..928		18/105 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1064		8/31 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900