DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and rpgra

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_021334464.1 Gene:rpgra / 571327 ZFINID:ZDB-GENE-070912-423 Length:1692 Species:Danio rerio


Alignment Length:1090 Identity:242/1090 - (22%)
Similarity:421/1090 - (38%) Gaps:202/1090 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly  3021 PIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQLPVLRQYVVKKVAVHSGGKHA 3085
            |:||:.|......|::.|:::..|:...|:|||.:...|..|..:.||:....:.||  .|..|.
Zfish    30 PVHISCGQSHSAFVTEQGRLFVFGDNNRGQLGLQIKGPVTKPVCVKVLKGERAQSVA--CGTDHT 92

  Fly  3086 LALTLDGKVFSWGEGEDGKLGHGN-RTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTW 3149
            |..|..|::.:.|...||:||.|: ..::...||........|:.::.|...|||::..|.|:.|
Zfish    93 LVSTSQGEILAAGGNSDGQLGLGHCNDSISFQRLRPFCDYAPIKLLSAGDHTSAALTEDGRLFLW 157

  Fly  3150 GLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRG 3214
            |....|:||.|:::..|.||.:.  .|:.:..|:||.|  .:..:|:.|.|:|:|:...|:||..
Zfish   158 GDNSAGQLGFGNDSHALLPKELN--MGQSIHWVSCGYR--HSALVTDSGDVYSFGESADGRLGLS 218

  Fly  3215 GSE--GSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVR-KPQP 3276
            ..:  ....|..:|.|.  .|:|:.||.:.:||||. .|::.:|.|::.:||.|....|. .|..
Zfish   219 AHQLANHSYPQRVESLH--SVLQVACGGKHTLALTE-DELYCFGGGEFGQLGLGTLVFVADSPVA 280

  Fly  3277 IGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGN-TFVNK-KPALVIGLDAVFVNR 3339
            :|..|..||.||..|..|...:||:|.:|.:||..||:.|.|: .|.|: .|.:........|..
Zfish   281 VGHFRKGRVTHVTCGEQHSALITDSGLLYTFGDGRHGKLGHGDENFTNQFTPTVCQRFFEYSVMT 345

  Fly  3340 VACGSSHSIAWGLPNASSDEE---KRGPVPFSSTRDPLGGSSLGIYEAETMQTLKQEAKPLN--- 3398
            |||||||.:.:..|....:||   :...|.:|             |......|:.| .:||.   
Zfish   346 VACGSSHMLVFARPRQQENEEVCLEDEDVTYS-------------YLDRCYTTMIQ-GQPLEHIP 396

  Fly  3399 --QSSL-SESLALETPAARQAALGHVLRAMSILQARQLIVAALTSHSKVNFKERGAV--GGEEDH 3458
              :|:| |:|.:|.:|.......                  :|::.::...||..:.  |.|..:
Zfish   397 DPESALVSQSTSLSSPLPTSHRW------------------SLSTRARRRQKESSSAQFGPEFSN 443

  Fly  3459 LIGGPIMGAPLQLAETIAQG----------GGEAPADATDAGLQEH--------SP------EAA 3499
            |.........|.|..||.|.          ..:||.|.:...|.:.        ||      |.:
Zfish   444 LPPLTTSYTALALTGTILQPRSAKGTPKHINTDAPVDTSITVLSKEPSFTPITKSPDDCQCVETS 508

  Fly  3500 VDALTGGMSGG------ANTLP-PLSAGPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMS 3557
            .::|:...|.|      ...|| .|....:| ..|:|.|.|.|..:.....|....:.......|
Zfish   509 ENSLSDKNSAGREENVFQQALPTELQVASVS-HPSITESQSSSNLMHKKPRPGDAENNAEVEEQS 572

  Fly  3558 VMAATMTQQEEMLSHISHCHGLDDFGG----LLGEPEAKSLVELLK-----------LAVCGRCG 3607
            .:.|..::.:..:...:.....:.:.|    :...|:..|..||.|           :|...|..
Zfish   573 SVTALQSKVQPKIVKTTIQSTNNRYKGKKIEVKSSPDGISAKELSKTWSTNIDLKETVAKADRYS 637

  Fly  3608 PPSTSQ---TIADTLISLGAGTPAVAAMLLETCITELEDLCTSRHCLGKLPKPVMQESSHPYVDN 3669
            ..|..:   |::||  .....:.::...|..:.:.|:|.:.|:.....::..|:.:|:..|...:
Zfish   638 KDSRGEEVITLSDT--EQETKSSSIKIPLTSSSVQEVEKVRTTPTSTQEVQSPISKEAGIPEKAS 700

  Fly  3670 VNVTGVVRI---PGAEM------------LRLEFDSQCST-EKRN-DPLVI---MDGTGRVLAMR 3714
            ..|...:::   |..||            :....::..:| |:|| .|:.|   |..|     ::
Zfish   701 KRVNSPIKVQEMPTGEMEVSKVKPTPQSDIEPSIETLINTQEQRNLTPVKITAEMQST-----LK 760

  Fly  3715 SGREFAHWAPEIRVLGDELRWKFSSDSSVNGWGWRFWVHAIMPAATLGESGSDRAVLSQPSMALV 3779
            .|.|    ..::....|....|..:                  ..|..|.|....:..|....|.
Zfish   761 KGNE----KMDVNTPSDHTAKKAKN------------------KRTAVERGPIAELSPQTPSPLS 803

  Fly  3780 MSLLDSRLAPRQPSVLLRLASALAACSQLGALTTAQRIWSLRKLHAVLLLEQAPRPQDPSLSTL- 3843
            :|...|::.|...|:.||.|......::.|...:.....|..:....:..:::...:..|.||| 
Zfish   804 VSTQKSKVEPENSSLQLRSAMQTQEATEKGETNSNSPQSSENRSFPTIKSKKSDAEKSQSASTLQ 868

  Fly  3844 -----LQPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLAALACDMQLDAALPATSSSSSSSAAP 3903
                 .|....:.|.:.:::.|.::.    :..:...:::.|..:.|     .||:.||:..||.
Zfish   869 SDQKNSQSSTNKALAEQKHKFPSIKS----LAPERSHSVSNLWSNNQ-----SATNKSSAPKAAE 924

  Fly  3904 -----GAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPR------------------AFCLEV 3945
                 .:.||:..:.:....||....|...:.:: .||.|.                  |....:
Zfish   925 SGKLFSSTSSSPQLRQSPLNKRKLKTVEDKEPVL-VTETPHQQSEQSLMGSVVSVLPAMAIAAPL 988

  Fly  3946 RKKFAEMLPSSS-SNSNANPGC-----QSPGASMLNSTTSLSSSTVSNVS 3989
            ..|.||:|..:| ..||....|     ::.|..:|........:||.::|
Zfish   989 LIKAAEVLSETSLEQSNEMSSCASASQETAGNKILIEQEVEQDTTVQDIS 1038

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826 15/50 (30%)
RCC1 3091..3140 CDD:278826 13/49 (27%)
RCC1 3144..3194 CDD:278826 16/49 (33%)
RCC1 3197..3246 CDD:278826 15/50 (30%)
RCC1 3250..3298 CDD:278826 16/48 (33%)
RCC1 3302..3350 CDD:278826 19/49 (39%)
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
rpgraXP_021334464.1 RCC1 5..43 CDD:306840 4/12 (33%)
RCC1 <31..324 CDD:332518 95/301 (32%)
RCC1 305..352 CDD:306840 17/46 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.920

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