DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and LOC567670

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	XP_021324683.1	Gene:	LOC567670 / 567670	-ID:	-	Length:	4796	Species:	Danio rerio

Alignment Length:	5549	Identity:	1315/5549 - (23%)
Similarity:	2016/5549 - (36%)	Gaps:	1707/5549 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 ALRAAGNCLS---------AQHLRQQLFIYERYFVALKRERERERKSTTSAQAVASVTTANTTIA 279
            ||..:..||:         |..|..:|.|.:|.|.||..:.....::....|          |.:
Zfish    81 ALLHSQRCLAHRMLARTPFALSLHHRLVILQRVFYALHSKYHDRFRAPLPPQ----------TSS 135

  Fly   280 ATTANAAVE--SQP---AEQQAEHGALGLARVATHAALNFSFAFLRRAWRSGE-----DTEMCSE 334
            ::....|:|  |:|   ...:::.|...|..:.....|:..||.||::|:.|.     |..:|:|
Zfish   136 SSAEGGALESVSEPWPTGSSRSKTGTDVLIEMGVRTGLSLLFALLRQSWQRGRLENPPDVALCNE 200

  Fly   335 LLSEALASLQELPEATLFEAAVVSSLWLEVMERSIKFLRLVALGDPMGNRCTAPLNDRHTALCLL 399
            :|:.|.:.|..||..:|.....:.::.|:.:.:...||:..|:.....:|.     .|..||.||
Zfish   201 VLATASSVLAALPPLSLANENKIPTVGLDCLAQVGDFLKKTAVSGSGADRA-----GRRLALELL 260

  Fly   400 LELGVQKGTLAATLECVVLLLLLWEKDRAGNDNRDMPRKTGAPLQRILLRYQKIGATAKGGGIAG 464
            |.|.:|:|:|...||.|.:.|.     .:.:.|.......|..|....|:..:.....:|..:
Zfish   261 LSLALQRGSLRFLLEWVEVALA-----ASASSNTSETVGVGYELIHQTLQQMRQHTAVRGESV-- 318

  Fly   465 GEPAPVASATETFLRFLSLPKSSAAIVDLRRAAVVIISHLDRMVQPLMPRCLLRGGQATAASSSS 529
                    .|:.      |.|.:..:..|...|:.:...:..:....:..|     .|.::|||.
Zfish   319 --------NTQV------LKKDADGLCSLSHVALCLFEEICTLASNCLCSC-----SAGSSSSSG 364

  Fly   530 APQQRIYALGWPSLSKDQ---------------QGFSAEPTLSWSGESAGVPTLSCRFQIK---Q 576
            :....:....|.|.|..|               |||| :..:..:|:       .|.|.:.   .
Zfish   365 SENDTVMVYVWGSNSSHQLAEGTLEKILQPKLAQGFS-DAQMIEAGQ-------YCTFSVSADGA 421

  Fly   577 VACCETQMLILSQEGKLYTWRLAKPEAE------------PLPMEEVAHDVFISIAGHCEGRHFL 629
            |..|          ||....||...::.            |..|.:|      |.:...:| |.|
Zfish   422 VKAC----------GKGSYGRLGLGDSNNQSMPKKLVLEPPRTMRKV------SSSKGSDG-HTL 469

  Fly   630 AIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKI-AALEQHCVQSVYCGCSYSAAITCGGNLLTWG 693
            |:.:....:|||.|:..:||||::..:..|..| ..|....|..|..|..:|||:|..|.|.|||
Zfish   470 AVTAEGEVFSWGDGDYGKLGHGNSATQKYPKIIQGPLLGKVVVCVSAGYRHSAAVTNDGELYTWG 534

  Fly   694 RGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEG-LVFAWGDGDYGKLGNG 757
            .|.:.||||.:|..|::||||..:|.  |..||.||  :|::|:..:| :|:::|.||.||||:|
Zfish   535 EGDFGRLGHSDSHSRNVPTLVKDISG--VGQVACGS--SHTIAVAQDGRIVWSFGGGDNGKLGHG 595

  Fly   758 NCNGSLQPILVESLPR--VQRVFAGSQFSVALSSEGQLYTWGKATCLGHQLVERSVQGCSV-PRL 819
            :.|...:|.::|:|..  :::|.||||.|:||:|.||::.||..:|||.    .|.:..|: |||
Zfish   596 DTNRVYRPKVIEALHGFIIRKVCAGSQSSLALTSAGQVFAWGCGSCLGC----GSSETTSLRPRL 656

  Fly   820 VSSLQHKRIVDVAVSVAHCLALSSSGEVFGWGRNDSQQICPASVSSEPLLRTPILVSLPTFPASG 884
            :..|...:|:|::...:||||||...|||.||.|...| |....:|.|:.:...::.|.......
Zfish   657 IEELSITKIIDISCGDSHCLALSHENEVFAWGNNAMGQ-CGQGHTSTPVTKPKKVIGLEGVSIQQ 720

  Fly   885 IACTSAQSLVWT--QSSHQGVPRRAPFVVDLGEPTFRLLDQLLGMCSSQDNRQTP------NQES 941
            |...::.||.||  .:..|.|....||.|||.|.||..|...|.......:..||      .:|.
Zfish   721 ITAGTSHSLAWTAVPTDRQLVAWHRPFCVDLEESTFTYLRSFLERYCDSISGDTPPAPFPSKREH 785

  Fly   942 ECIAVACLNLFRLQLLALIANGVEPRQVGLASGSRLLCSLKTRILGLAGGSQVLRTIQVAAQQAL 1006
            ....:.|:.|..:.|....|.|.....:| |.| |.|.:|..|::    .|.|..:||.|....|
Zfish   786 HQFVLLCMKLLSIHLSLAHAGGTGATVLG-AQG-RPLRNLLFRLI----DSNVPESIQQAVISTL 844

  Fly  1007 QDGWSVLLPTAAERAQTLTSLLPSEP--GQASSAGHRFMTDLLVSSLMAEGGLESALQHAIRLE- 1068
            ..|.|:|||...||.:.|.||||..|  .::.|.|.|...|::::||..:..:.|.|.::...|
Zfish   845 SMGASLLLPPLRERTELLHSLLPQGPESWESLSKGQRLQLDMVLNSLQEQSHVASLLGYSSPGEL 909

  Fly  1069 ---------------SSSCSADCGDGVHLPLLQLITRLLSNNAALSQTRLSPTLGKQQEKEEEER 1118
                           |.|.:::..|.:||..:.|.|.|||......:     ..|:.::..:::|
Zfish   910 SAGLALPPTPDRPTGSVSSNSESPDHLHLAEVLLKTLLLSIGFYTER-----AFGELEKNSDKQR 969

  Fly  1119 EQQHQEPSTSPS-----LSLLHRFQRLLLSH--IHQAQPEEETTGAE---ALLLQYMH--ALIPA 1171
            ..|.|:.:.:||     ||.|||.   ||:|  ||        ||||   ::||.:.|  .|:|.
Zfish   970 FSQSQKQTEAPSHFHHLLSALHRH---LLAHCYIH--------TGAEDDSSVLLLHKHLCLLLPY 1023

  Fly  1172 CVATLQKAHELALQCREPGENSFGQ-MVGHLGRVLQADISDALLNELLVGLLLLKRDRPQCLGGL 1235
            ...|.::: .:.|:     |::..: ::..|..||...::.:||.:::..||||.         |
Zfish  1024 AAETFRRS-TILLE-----ESTLDKHVINKLHTVLFGSVAGSLLCQVMYSLLLLP---------L 1073

  Fly  1236 RWARLFLP-LLRVLDRLNRALG--------------EGELRDGDDMGWPGII------------- 1272
            ...:..|| ||.:|:.||. |.              ||.|::..::..|.::
Zfish  1074 AVVKPLLPHLLTLLEHLNE-LNCYLPNTAHLEDMELEGNLQEPSEISEPVVVEESDDWAWLLDLE 1137

  Fly  1273 ---------CRGGPKGGPPPADPETHYVRRAD--MENLLLDGSRCIILAGYVCDLSGYNCESETL 1326
                     |.||...||||:..|    :.|:  :.|.||..       |...|....:.....|
Zfish  1138 RSVALAIGRCLGGMLQGPPPSIQE----KTAEFWLCNPLLRN-------GLEIDFEQLDWAMGWL 1191

  Fly  1327 RSVLDSGLGKDLTAEMS-SQVHRTAMEHILEH---------HKLGKYMVQASTE--EKSSAPGPS 1379
            ...:..|.|....||:. |:.:.|.:|..|..         .|:.:|   |:|.  :.|.:.|.|
Zfish  1192 TEAVFMGCGDVRLAELRLSEENTTLVELALGSPREPASALWRKMKEY---AATRDWDSSGSVGDS 1253

  Fly  1380 RLTHFSSECALAQLLGLVANLMCSG-------PALQPAEL-----QCRQLDKSSLLSGGLQLLQP 1432
             |...:..|:||.|      |..||       ...:|.|:     |.....:::|::
Zfish  1254 -LLETACRCSLAAL------LKHSGLHEAYWQDKYEPCEVLIEIYQVVYKIRNTLMA-------- 1303

  Fly  1433 SNPFDEEKGEARSSHSCHST-----AGNTPTELPPPLPMQQQLAPGRGKSQLQLRADAFISGLAE 1492
               :.|..|...|:.:..||     ...:|:|       ::|.:   |.|..|...||..|
Zfish  1304 ---YKESIGNTTSAQAPSSTKQASLGSQSPSE-------ERQES---GSSGEQTGRDAEFS---- 1351

  Fly  1493 ARVSEPPVAAWLALTERYCKAHNLMWHQEFATEHPVQELERLLSAVLIRHQYLGGLVLNALETEV 1557
               |:.|.||          .||        .:.|::|....:|::     ||..::...|.|..
Zfish  1352 ---SQTPQAA----------EHN--------QDDPLEEETPSISSM-----YLPEVLQCFLATRE 1390

  Fly  1558 PPPRQLGEII--------------------RLVHQAKWSVVRTRQQLNRSYKEVCAPILERLRFL 1602
            ....|..|.:                    |...|..|....|..| ...:...|..::.|..||
Zfish  1391 AMQLQQNETVYESSGTSTLPSSTESPGTPDREPSQRPWDHHSTSDQ-GLPFPAACHLLVSRCLFL 1454

  Fly  1603 LYEVRPA--------ISPQQRGLRRLPILQRPPRFKMLVRRLLQELRSS--RQPAKPEDLLNASI 1657
            |..||.|        .:|.:..|.|.|........||       ||:||  |:.::.|....:..
Zfish  1455 LLGVRAAWQEESMSSQTPTESSLARSPAYYEALGAKM-------ELQSSSERRFSEREIPDQSKS 1512

  Fly  1658 QQEQEKKPQSMPKQELEEQEEE-ETLLRRLNERQIHGEGELDPALMQDIVDF---------ALQD 1712
            .....|....:|...|...::. |.|.:.::...:...|.....::..:..|         :|.|
Zfish  1513 SSGSFKNKMGLPLCSLGIMKDAWERLRQCISPTTVLYPGGGGTPILAQVFHFLCGSLLRTSSLMD 1577

  Fly  1713 S-----CDVETARRAMYCQMQRYQLRLAGL-QIVQQLLELH-------------GLLDAAQYSLL 1758
            .     .|.:....||..|.||.|:||..| ||...|.|:.             |||.:.|...|
Zfish  1578 KDGGTHADPKAITVAMAQQHQRAQVRLEALCQISSFLSEMEEKSVSSLAPPRFPGLLQSVQLQFL 1642

  Fly  1759 NGFLGLHLKSTSSGGGSTGS----GSSLH--VLGQLNMISAYQKARLLLAQSRVLDWAVRELRRL 1817
            :|..||       |...|||    .:.:|  ..|..:...:.|: .|..|...:....||.||:.
Zfish  1643 SGCFGL-------GAPITGSLAAPNNKIHHYTAGTQSAPISVQR-ELQCAAHMLYQQLVRVLRQK 1699

  Fly  1818 VNQEQQGHARGKDSTNLGTYVLLKRLPRARFLLSVFGLLAKELGPNELGFLINSG---LLGTVLG 1879
            |..|::         ..|:|..|       .|.:||. |.....|.:|..:|..|   :|.|:..
Zfish  1700 VALERE---------QAGSYQHL-------LLATVFA-LNFHYQPVDLVVIIKCGVLEILSTLTD 1747

  Fly  1880 ----------LLAQTGGEGATGG--------------------------------------QVHG 1896
                      |.|...|....||                                      |:.|
Zfish  1748 NTCVLVNQRWLAASMSGHMQLGGAVKLAAARLLQIFAIAASSCEEALPLDVSQALMDVMSEQLQG 1812

  Fly  1897 ELSILYEDSVLKQKSSKA---QLSGPDLAKLMK-IGTRIVRG--ADWKWGDQDGNPPGEGRIIS- 1954
            .|..:::..||::.|:::   :....::|.::: ..:|:|..  ||:....:        ||:|
Zfish  1813 LLHAVHQQEVLERNSTESIPEETPKQEIADVVRSSSSRVVESQLADFLVFLR--------RILSL 1869

  Fly  1955 EVGEDGWVRVEWYTGATN--SYR--MGKEGQYDL------------------------QLADSAL 1991
            .|.:.....|:|......  ||:  .|....|:|                        |:.|...
Zfish  1870 RVAKRVSAFVKWIDPLMTVISYKCSSGNPRFYNLRTKLLAFHILEALLPACADPVIMKQIVDQLF 1934

  Fly  1992 NVASP-----------------TEPEREDVSGS--EASPTSD--SHPSKLLRHCAAKLLQILAVG 2035
            ::.|.                 ||...:| |||  |..|..|  ..|.||: .|:.:...:|:.|
Zfish  1935 SLLSTYMWEEPVALRKAVDKERTESSEKD-SGSEDECIPIGDFSFDPHKLI-CCSLESGNVLSHG 1997

  Fly  2036 TGLHGAQLDKDALRGMTSMFRTIIYPKPSMSNISYALG---W----------LNLGFIRAISGDC 2087
            :|..|..|...|:.....:::..| .|.:..|....:|   |          .::...||.||.
Zfish  1998 SGGKGYGLATTAITSGCFIWKFYI-TKENRGNEGTCIGVSRWPIRDYNHRTTTDMWLYRAYSGS- 2060

  Fly  2088 PRLCLELSTPGWLSHYLSLLEQPAGNEAG----VYRQ---LHCL-----RLLQLI-------LAQ 2133
                        |.|         |.|.|    .:.|   :.|:     |.:...       ||.
Zfish  2061 ------------LYH---------GGELGRALPSFTQGDTITCILDMEARTISFAKNNREPKLAF 2104

  Fly  2134 WGAEEEPRMPALVHQLFATLGRIALHC------------PGDASLLPTAEGKARVLLTASHSGSV 2186
            .|.:.....|.::........::|| |            ||:    |....:|.|||
Zfish  2105 EGVDATELYPCVLFYSSNPGEKVAL-CDLQMRGMPSDLLPGE----PLCSPRATVLL-------- 2156

  Fly  2187 AEELVALLRRLHTLPSWNPVINSFLAQKLCVAAELLAEQSHS----------------------- 2228
             |..:.|||||:....|...||..:..||.:...|:.: .||
Zfish  2157 -ESTIQLLRRLYVNDDWLQHINQHMLNKLQLINPLMRD-GHSKMGQASKESDEKCGLNRERASAW 2219

  Fly  2229 -------------TALDSEQVFVL-----GVLGAMGGHDLRPRVGLHCFHEGSHMVIASFTPKGR 2275
                         ..|...|:.||     .|:..:||.|...|.|..|.|:.|          ||
Zfish  2220 ADVGSSSDHLSGPAGLSDAQLSVLCCEVWPVMALIGGVDSGLRAGGTCLHKSS----------GR 2274

  Fly  2276 CLLAPGGVGSGVGFVKVQLPAVMPHLDHTVFSLSRLPMNEMLLNAWTVLLYGPAPELRELPSSAD 2340
            .....|.:..|....|:|       .:.|.|::|       .||:|
Zfish  2275 RATLLGVLKEGSPLAKLQ-------WEETDFTVS-------FLNSW------------------- 2306

  Fly  2341 GRLDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDAESQQPGEQDQ 2405
                                                         ||.:...|..|.....:.|
Zfish  2307 ---------------------------------------------SPSDTPLSSLEPCDVPQMD- 2325

  Fly  2406 QLSSGSGQEPQLLIQCILLRA---TQASPVKACYSYMDLATAALNCIQSLATQAHQELSEGGGVP 2467
             :|...|.:|.:|...||:..   .|..|                 ..|...|.::..||||
Zfish  2326 -MSRCCGLKPSVLFDLILMTGILEEQEPP-----------------STSSGMQRNRISSEGG--- 2369

  Fly  2468 PNGRALSSPPQPTMVHGVPVYNVARKEQKPSEQVEQKSKWPAAATDAQLIGQIMEMGFTRRTVEL 2532
                                         |..::|                         |.::.
Zfish  2370 -----------------------------PRNELE-------------------------RRLDE 2380

  Fly  2533 ALKQLSLQAEIMPTPEQIVQWILEHPDVCANTIEEDTLPLASSASSHDPEADSDNECPSSNSTTS 2597
            .:.::.:..|.|..|                 ::||    .:.......|...|...|...||.|
Zfish  2381 DIARIIMDEESMSCP-----------------VDED----RNKVEDRRDENQEDTFRPLIKSTES 2424

  Fly  2598 SSTSSDTVEGQPMAVSGPAPPVKFESRKDFQTADLYALYVR----GLVRPGMTVRCCRDFEEIKQ 2658
            :.                ||.:..:.|.||...:|.|:.:.    |.::....:..|..|.::
Zfish  2425 TC----------------APILAPQPRADFFALELRAVRISYLLLGALKSLAVILSCGKFTDL-- 2471

  Fly  2659 GDMGTVLIVDTEGLHDLNVQVDWRNHGSTYWVCFVHIELVEAAQTHHQPRPPPIAVG-ARVRLRT 2722
                 :|:..::.:                    |::...:.|:|.        ||| ....||:
Zfish  2472 -----LLVPKSDAV--------------------VNVTSPDPARTS--------AVGEENAELRS 2503

  Fly  2723 -------SSLRYGML-CPLR-------LGRSQGSSAIGVVSSVR---SKQLTVDFPDQPAWQGHI 2769
                   |.:::.:. ||::       |.|:|.....|.:|.::   ||:             |.
Zfish  2504 VLQFVVRSMVKWAVRPCPIKQAMALSDLERAQIIIFKGALSRLQEDGSKE-------------HK 2555

  Fly  2770 NEVELVASQPTSATLPSL-------------GDSCSQMPPSDLIEDWSRCIRSLTVSSNEAAAKH 2821
            :.....:|||.|.:..|:             |.|.|   ||         ...||.|...|....
Zfish  2556 DSGTHSSSQPVSKSSSSVSLYSNGSEGTAIFGQSAS---PS---------TNDLTASLLTALQAD 2608

  Fly  2822 LLNGSNQPWQSCSSGPCRHWIRLELHDRI----------LVHSLTLKVSPEDHSHMPSLLEIRVG 2876
            .|...|.            ::.:.|..|:          ||||..|.         |.|......
Zfish  2609 GLENFNP------------FLPINLLQRMVLARFPTLAGLVHSPVLP---------PGLSLTSSA 2652

  Fly  2877 DCVDSLKEYTWIPVPAGASRVLLMQQVPTYYPWVEVVVKQCQNNGIQCKIH-GIKFVGRRQQPDL 2940
            .|....::.|....|.|.:|      .|...|.:.|.|:..:.......|: .::..|...:.|.
Zfish  2653 SCEGFTEQQTSFLEPCGQTR------TPVEQPQMFVPVRLLEMGFSMRHIYRAMEAAGVTGEVDS 2711

  Fly  2941 QHILANAQF-----LASEYSAGVGPGSTAGA-GAVSTSHEEAAAAPEQDLPCTVMVWGLNDKEQL 2999
            :.|...|.:     :|.|..||.| .||.|| ...|:...|....||...|.|     |.|..:
Zfish  2712 RTIEVLASWMLEHPIAEEQQAGEG-SSTGGATDTPSSEGPETVQCPESPAPLT-----LQDSRE- 2769

  Fly  3000 GGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTHNVPLPHQ 3064
                      |..|.         :||    |.:|.::           ..|.:.:|.|.|.|.:
Zfish  2770 ----------PNDSL---------LAG----LDLVERE-----------NFLDVHLTRNRPPPAR 2800

  Fly  3065 LPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDK-----PRLVEALRA 3124
                ||                                 :.|.|.||:..:     |..|.||..
Zfish  2801 ----RQ---------------------------------RSGVGQRTSFRRADSPSPSPVPALYR 2828

  Fly  3125 KKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQ-------LKPKLVTALAGRRVVQV 3182
            :::        ..|....:.|.:.:...|...||:.|:..|       |.|:.:|:
Zfish  2829 QEV--------GVAEWPERAETHPFAAEEDSELGYMDDPYQEEPYEELLTPEFITS--------- 2876

  Fly  3183 ACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALT 3247
               .||  ||.:.|                  |.|....|||:          :||....:|.|.
Zfish  2877 ---ERD--TLWMVE------------------GREEHPEPHEM----------VECELCNTLTLQ 2908

  Fly  3248 RAGEVWTWGKGDYYRLGHGGDQHVRKPQP----IGGLRGRRVIHVAVGALHCLAVTDAGQVYAWG 3308
                               .:.|:::..|    ..|.||.|              ::...|..|.
Zfish  2909 -------------------FNNHMKRHHPGCGQSAGRRGYR--------------SNGAYVDGWF 2940

  Fly  3309 DNDHGQQGSGNTFV-------NKKPALVIGLDAVFVNRVACGSSHSIAWGLPNASSDE------- 3359
            .   |:.|||:.:.       .|..||.:|:.:...:| |.|....:...|.:.|.||
Zfish  2941 G---GECGSGSPYYLLCSTCREKYLALNMGVMSSKQDR-AKGLVSDLIGQLDSTSEDEWDPVNQE 3001

  Fly  3360 -----------------------EKR---GPVPFSSTRDPLG----GSSLG----IYEAETMQTL 3390
                                   ||:   .|:||:. .||||    |:..|    :|.......|
Zfish  3002 DSDSDRLTGLEDFGILLRPLGLSEKKPVPEPIPFTE-HDPLGALVSGAGSGGENLLYRGVVSTEL 3065

  Fly  3391 KQEAKPLNQSSLSESLA-LETPAARQAALGHVLRAMSILQARQLIVAAL---TSHSKVNFKERG- 3450
            |..:.||   ||.|..| |..|..|..||..|.....||.|..:::.||   :|.|.|..:..|
Zfish  3066 KSSSAPL---SLGEQAASLREPQERLLALRRVTSTAQILLAYSMVMRALSQTSSSSSVCNQSSGL 3127

  Fly  3451 -AVGGEEDHLI--------GGPIMGAPLQLAETIAQGGGEAPA------------DATDAGLQEH 3494
             |:|..:..::        ||.:.....|      ||.|...|            .:....|..|
Zfish  3128 EALGLADIRILVRLMCLAAGGRVQTGMDQ------QGMGRGSASDRPGSAFLSFLSSAIGSLVSH 3186

  Fly  3495 SPEA---AVD--------ALTG--------------------GM--------------------- 3507
            ||.|   .||        |.||                    ||
Zfish  3187 SPAAYRELVDICTQDLMAAATGMNISAIADPQQRTRQGSALKGMVLQEPRELTPPTFLVTQSLVS 3251

  Fly  3508 ----------------------SGGANTLPPLSAGPLSAFQSLTGSLSMSGSLSS---SALPQHK 3547
                                  .||:   ||.|...||......|.|.::.:|::   ||....:
Zfish  3252 LLTEKGIRYRYNLERSESVESKDGGS---PPPSGPSLSQAGVRVGPLELANALAACVLSARLTSR 3313

  Fly  3548 HSRMSASAMSVMAATMTQQEEML------------------------SHISHCHGLDDFGGLLGE 3588
            |.:.:|..: |.|..::::|...                        :.:|.| ..:...|||..
Zfish  3314 HRQWAAQQL-VQALAISEKENTARPQTYSDMAGDLRKCPVRKLEGHQNRVSSC-SWNAEQGLLAS 3376

  Fly  3589 PEAKSLVEL-------LKLAVCGRCGPPSTSQTIADTL-------ISLGAGTPAVAAM------- 3632
            ......|.|       .:|.....|.....:|:...::       :|..||...:||.
Zfish  3377 GSQDGTVRLWNITPNSAELQHTHTCSISEDAQSSDASMGSHLLSAVSWSAGGTLLAAFQNKLINI 3441

  Fly  3633 -----------LLETCITELEDLCTSRHCLGKLPKPVMQESSHPY----------VDN----VNV 3672
                       ...:.||.|..:.||...|       :||:|...          :|.    :.|
Zfish  3442 WTVNGTQAHIEAQSSWITALSWVQTSTPFL-------IQEASSQLNPPESLLVGRLDGSLCWLEV 3499

  Fly  3673 TGVVRIPGAEMLRLEFDS--QC----STEKRNDPLVIMDGTGRVLAMRSGREFAHWAPEIRVLGD 3731
            |..:|:...|::......  ||    |.||   |..:....|::| :.:...:....|.:.....
Zfish  3500 TEDLRVDRTELMHCHRKEAPQCLAWYSIEK---PFAVGYPDGKIL-LGTAESYETEPPILLTAFP 3560

  Fly  3732 E----LRW--------KFSSDSSVNGWG--WRFWV--HAIMPAATLGES--------GSD----- 3767
            |    |||        .......|..||  ...||  |::....|:..:        |:|
Zfish  3561 ESVSALRWDPTGHLLLSVGRSEVVKIWGRAGGAWVTLHSLFHTGTVNTAEWCPLPGRGADPRLMM 3625

  Fly  3768 -----------------RAVLSQPSMALVMSLLDSRLAPRQPSV--LLRLASALAACSQL----- 3808
                             .|.:|.|:.....:..|...|.::.:.  :.||:..:.|...|
Zfish  3626 AVGCQNGLLYVWTVPQGGANVSVPNFLTPSTSQDKSSAIKRGTAKCMFRLSGHITAVKTLSFCPS 3690

  Fly  3809 ------GALTTAQRIWSLRK----------LHAVLLLEQAP---------RPQD----------- 3837
                  |.:.....|||||.          :.:|:.....|         |.:|
Zfish  3691 GLALVSGGIGGLLNIWSLRDGSVLQTVVTGMGSVVCTTWIPHIGVTACSGRSKDVLLIRCTSDWI 3755

  Fly  3838 ------------------------PSLSTLLQPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLA 3878
                                    |.::..|:.|...|..||.||:..|..|..|.||.:.::|:
Zfish  3756 SQNHILASCRSVLRSQGILGLNRAPCMAVFLERLPTLLQEQYNYEKSHVMAGDQLTHSAFLQSLS 3820

  Fly  3879 ALACDMQLDAAL---PATSSSSSSSAAPGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPRA 3940
            :||..:.||..|   |.....|...........:....:|.|...|...|:.|::..|.|..|.|
Zfish  3821 SLAMGLFLDQLLCRQPKPPHHSGMGPVQDGAHGSFCPSEWNWLSTYSTTVKSAEAFARGTPFPEA 3885

  Fly  3941 FCLEVRKKFAEMLPSSSSNSNANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQPDLHCHA 4005
            |.                                                       .|:.| |.
Zfish  3886 FI-------------------------------------------------------APEFH-HP 3894

  Fly  4006 HQLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRI 4070
            ...|.|..|   |::.:....|.||:.|...||:||  ..||.|.:|.||:...|||.. .|:..
Zfish  3895 GAAEFTKPL---DNSKWTFMMDEQLMSWATSRPEDW--QQGGKSEVYLWGNGRHGQLAD-AGTSA 3953

  Fly  4071 KTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLLGSLQHVF 4135
            ..||...:||  :..|:..|:...|.|..:|.:.|.|.||.||||.|.||....||::.:||...
Zfish  3954 SVPTLAPSLS--QTQQVVCGQNCTFLVQANGTVLAVGEGSYGRLGQGNSDDLYTPTIISALQGYV 4016

  Fly  4136 VKKVAVNSGGK-HCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAH 4199
            |.::..:.|.. |.||||..|||::||:|:.|||||||.....|||.:|.|.|..|..:|||..|
Zfish  4017 VTQLVTSYGSDGHSLALTETGEVFSWGDGDYGKLGHGNSERQRRPKQIEGLQGEEVVQLACGFKH 4081

  Fly  4200 SAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDD-NV 4263
            ||.:||.|.:.|:|.|..||||...:.:::.|:.|.||.|:....::||..  .||.::.|. .|
Zfish  4082 SAVVTADGKLFTFGSGDSGRLGQRSTSNKMIPERVTALDGHHIGQVSCGIN--HTLVLSSDGLTV 4144

  Fly  4264 WSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDFHRLGH 4328
            |::|||||||||.|.......|.|:|||...|:.||.||:.|||.|.|.|.:||:|:.....|..
Zfish  4145 WAFGDGDYGKLGIGPCTVKCYPQKVESLCNKGIKKVGCGTHFSVVLAKDGHIYTFGQERLIGLPD 4209

  Fly  4329 GSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQRPRLVA 4393
            ..:.:..||:.:.||:|..|..||.|..|.:|.|::|:||.||.|.|.|||.|....::.|.||.
Zfish  4210 AMLKNHNRPQIIPALEGVFIEDIAVGCEHILALSNTGDVYAWGCNCEAQLGLGHSNPVKEPILVT 4274

  Fly  4394 ALQGKHIVKVTCGSAHTLALSTSQLSERLR---------PLPNPPLEYDLVRDLAPEALHARLIL 4449
            .||||:|.:::.|..|:.|.:|..||.|..         |...|| :|:.::|.:||.|:.||.:
Zfish  4275 TLQGKNIRQISAGRCHSSAWTTPALSTRASGCSGIQLGLPQSVPP-QYNALKDCSPEVLNTRLRV 4338

  Fly  4450 LHHFSELVCPCLAMLPI------------SGDLSL--GALKDVLVYNIKEAAFRKVIQTTMVRDK 4500
            |:|||:|:.....:|.:            ||..::  |.|:.:|...:......:.|..||.:.|
Zfish  4339 LYHFSDLMYKSWRLLNLDPRSQVSTSRYSSGTAAIVQGQLRGLLSPKVNTLPLVRTIGRTMTQGK 4403

  Fly  4501 QHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVWKVKFVGESVD 4565
            .:||.|.:.||.   :|.|.:        |.:|.|:.:::..|....|.||.|.||||.|||..|
Zfish  4404 TYGPQITVKRIS---TRGRSS--------KPIFVQIAKQVVNLNPTELRLPSRAWKVKLVGEGAD 4457

  Fly  4566 DCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMG 4630
            |.||.:.::|.|||.|||:|.|.|||:|||...:.|:|.|.|||:|...|...:..|||||:||.
Zfish  4458 DAGGVFDDTITEMCQELQSGVVDLLIHTPNSTADVGSNTDRFLLNPGAFSDDHIVQFRFLGILMA 4522

  Fly  4631 IAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDD---DPKLFTALELPF 4692
            :|:||..||.::||..||:|:....|...||.|||......|..|.::|.   :.:.||.: :|.
Zfish  4523 VAIRTKKPLDLHLAPWVWKQMCCIPLGAADLEEVDLLTYRSLQGILHLDSSVINEENFTVM-IPL 4586

  Fly  4693 STSSAR------------GHEVPLSTRYTHISPRNRAEYVRLALGFRLHEFDEQVKAVRDGMSKV 4745
            .:..|.            ||.:||:.       .||.:||..||.:||||.|.||.|||:|||.:
Zfish  4587 DSFVAHSADGTLVPVIPGGHNLPLTF-------SNRNDYVERALHYRLHEMDRQVSAVREGMSSI 4644

  Fly  4746 IPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFLR 4810
            ||||||||.:|.:|:.:|||.|::.:.:||.|..|:....|..|:.|.|:.:|||||:||.||||
Zfish  4645 IPVPLLSLLTARQLEQLVCGLPEVSVEMLKKVVRYRDITDSHQLIGWLWQSLEEFTNEERVLFLR 4709

  Fly  4811 FVWGRTRLPRTIADFRGRDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIHF 4875
            ||.||:|||...||...:   .|:::.:.|.:.||.:.||||.|::|.|:.:|:|.|:|:|:||.
Zfish  4710 FVSGRSRLPSNPADITQK---FQIIKVDRPVNGLPTAQTCFFQLRLPPYTSQAILAERLRYSIHN 4771

  Fly  4876 CKSIDTDEYARVAMGEPTEATGSE 4899
            |.|||.|.|......:|.:|:.:|
Zfish  4772 CPSIDMDNYMLSRNTDPADASDTE 4795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826	16/45 (36%)
		RCC1	687..737	CDD:278826	23/49 (47%)
		RCC1	740..787	CDD:278826	20/49 (41%)
		RCC1	790..841	CDD:278826	18/51 (35%)
		RCC1_2	828..857	CDD:290274	14/28 (50%)
		Cyt-b5	1290..1363	CDD:278597	16/84 (19%)
		MIB_HERC2	1928..1987	CDD:284184	16/89 (18%)
		UBA_HERC2	2515..2559	CDD:270585	4/43 (9%)
		Cul7	2624..2699	CDD:288381	10/78 (13%)
		APC10-HERC2	2762..2932	CDD:176485	36/193 (19%)
		RCC1	3037..3088	CDD:278826	7/50 (14%)
		RCC1	3091..3140	CDD:278826	9/53 (17%)
		RCC1	3144..3194	CDD:278826	13/56 (23%)
		RCC1	3197..3246	CDD:278826	8/48 (17%)
		RCC1	3250..3298	CDD:278826	6/51 (12%)
		RCC1	3302..3350	CDD:278826	13/54 (24%)
		RCC1_2	4136..4166	CDD:290274	13/30 (43%)
		RCC1	4154..4203	CDD:278826	26/48 (54%)
		RCC1	4206..4257	CDD:278826	17/50 (34%)
		RCC1	4260..4309	CDD:278826	26/49 (53%)
		RCC1	4312..4360	CDD:278826	15/47 (32%)
		RCC1	4364..4413	CDD:278826	21/48 (44%)
		HECTc	4509..4880	CDD:238033	161/385 (42%)
		HECTc	4553..4878	CDD:214523	149/339 (44%)
LOC567670	XP_021324683.1	RCC1	371..724	CDD:332518	123/386 (32%)
		SPRY_HERC1	1975..2131	CDD:293939	34/180 (19%)
		UBA_HERC1	2682..2725	CDD:270584	7/42 (17%)
		WD40	3351..3707	CDD:330360	62/367 (17%)
		WD40 repeat	3362..3400	CDD:293791	8/38 (21%)
		WD40 repeat	3420..3451	CDD:293791	5/30 (17%)
		WD40 repeat	3458..3512	CDD:293791	14/60 (23%)
		WD40 repeat	3520..3557	CDD:293791	9/40 (23%)
		WD40 repeat	3563..3587	CDD:293791	4/23 (17%)
		WD40 repeat	3606..3653	CDD:293791	5/46 (11%)
		WD40 repeat	3682..3718	CDD:293791	7/35 (20%)
		RCC1	3869..4282	CDD:332518	171/478 (36%)
		HECTc	4408..4776	CDD:238033	162/389 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010