DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and rccd1

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	XP_009296664.1	Gene:	rccd1 / 567613	ZFINID:	ZDB-GENE-030131-3552	Length:	312	Species:	Danio rerio

Alignment Length:	301	Identity:	90/301 - (29%)
Similarity:	123/301 - (40%)	Gaps:	92/301 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  3053 LGVTHNVPLP--------HQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGN 3109
            |...|...||        |:.|......:..|::..|.:|||.||.||.::|||.|..|:||||.
Zfish    61 LSAEHTAALPLVSGGFVQHKPPFFHPLKLCAVSLVLGSEHALLLTADGTLYSWGSGSHGQLGHGA 125

  Fly  3110 RTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTAL 3174
            .|:|:.|:.||||....|:.||.|:.||||:||.|:||.||..|.|:||               |
Zfish   126 LTSLEDPQAVEALWGVPIKAVAAGNWHSAAVSSGGDLYMWGWNESGQLG---------------L 175

  Fly  3175 AGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVV----- 3234
            ..|               .|.|:            |....||...|.|...:..|...|.
Zfish   176 PSR---------------GLEEE------------KRRGNGSGNDDQPMNTDEKSQTDVFISIQA 213

  Fly  3235 --------------QIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRV 3285
                          :|.||::.:.|:|.||:::|||.|.|.:||||.:....:|.|:...
Zfish   214 FPALVDIANMSEISRISCGSRHTAAVTSAGDLYTWGWGQYGQLGHGTEHSTDEPTPVDYF----- 273

  Fly  3286 IHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKP 3326
                  :.|.|:|.|.            ..||.||||:..|
Zfish   274 ------SSHSLSVKDV------------VCGSWNTFVSVVP 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826	11/42 (26%)
		RCC1	3091..3140	CDD:278826	25/48 (52%)
		RCC1	3144..3194	CDD:278826	11/49 (22%)
		RCC1	3197..3246	CDD:278826	10/67 (15%)
		RCC1	3250..3298	CDD:278826	14/47 (30%)
		RCC1	3302..3350	CDD:278826	7/25 (28%)
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
rccd1	XP_009296664.1	RCC1_2	92..120	CDD:290274	13/27 (48%)
		RCC1	107..156	CDD:278826	25/48 (52%)
		RCC1_2	143..172	CDD:290274	16/28 (57%)
		RCC1	160..239	CDD:278826	23/120 (19%)
		RCC1_2	226..255	CDD:290274	12/28 (43%)
		RCC1	243..292	CDD:278826	20/71 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920