DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and plekha5

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	XP_021330752.1	Gene:	plekha5 / 567300	ZFINID:	ZDB-GENE-041210-25	Length:	1398	Species:	Danio rerio

Alignment Length:	1137	Identity:	220/1137 - (19%)
Similarity:	371/1137 - (32%)	Gaps:	411/1137 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   832 AVSVAHCLALSSS----GEVFGWGRNDSQQICPASVSSEPLLRTPILVSLPTFPA----SGIACT 888
            |.:.|...|:|||    .:|.|.|.....: .|..:|:   :||.  |..||.||    ..::.|
Zfish   483 AQAAAIAAAVSSSRMMQKQVNGSGERAGDR-SPGDLST---VRTS--VPPPTQPAPEPERSLSRT 541

  Fly   889 SAQSLV--WTQ--------------SSHQGVPRRAPFVVDLGEPTFRLLDQLLGMCSSQDNRQTP 937
            |:...:  |.:              :|:|.:||..|
Zfish   542 SSMQQLEQWVRTHRTRAPDDDTRSITSYQTLPRNMP----------------------------- 577

  Fly   938 NQESECIAVACLNLFRLQLLALIANGVE--PRQVGLASGSRLLCSLKTRILGLAGGSQVLRTIQV 1000
                         ..|.|::.....|..  ||.: |...|  :||:        .||...|.:|.
Zfish   578 -------------SHRAQIVPRYPEGYRTLPRNM-LRPDS--ICSV--------AGSVYDRALQP 618

  Fly  1001 AAQQ---ALQDG--WSV---------------LLPTAAERAQTLTSLLPSEPGQASSAG-HRFMT 1044
            :.|:   :::|.  |.:               .||:.....|...| :|:.|...|.|| |.|..
Zfish   619 STQEKRRSIRDDTMWQLYEWQQRQAHSRLGYGTLPSPKTMGQIAES-IPTSPSHGSLAGYHTFSP 682

  Fly  1045 D--------LLVSSLMAEGGLESALQHAIRLESSSCSADCGDGVHLPLLQLIT-RLLSNNAALSQ 1100
            :        ..:||.:..|.:....:|...|...|..|:....   |..|.|| :.|........
Zfish   683 NRPLNPDSRSELSSPVFRGDVTIERRHRPHLSKYSYPAERRAA---PPAQNITAQSLQGKTPEEL 744

  Fly  1101 TRLSPTLGKQQEKEEEERE------QQHQEPSTSPSLSLL-HRFQRLLLSHIHQAQPEEETTGAE 1158
            |.|...|.:||.:....||      .|....:|:|...:| |..||.|: ::.....|.|.
Zfish   745 TLLLIKLRRQQAELNSLREHTLAQLMQLNLDATNPKSEILSHHLQRNLM-YLDSQMKENEP---- 804

  Fly  1159 ALLLQYMHALIPACVATLQKAHELALQCREPGENSFGQMVGHLGRVLQADISDALLNELLVGLLL 1223
              ::..:|.:|... |...:.::..:...|..||::      :.|..:.|: ||.|:.      |
Zfish   805 --IIFMIHTMIENS-APRPQLYQQQMSPEEYRENTY------MYRPEELDV-DAKLSR------L 853

  Fly  1224 LKRDRPQCLGGLRWARLFLPLLRV----LDRLNRALGEGELRDGDDMGWPGIICRGGPKGGPPPA 1284
            .::|:               ::|.    |.:|:|
Zfish   854 CEQDK---------------VVRTQEEKLQQLHR------------------------------- 872

  Fly  1285 DPETHYVRRADMENLLLDGSRCIILAGYVCDLSGYNCES----ETLRSVLDSGL---GKDLTAEM 1342
              |.|     .:|..||..|:.|       ::|..|..:    ...|.||.|||   .::| :.:
Zfish   873 --EKH-----TLETALLSASQEI-------EMSSENPAAVQSVVQQRDVLQSGLLSTCREL-SRV 922

  Fly  1343 SSQVHRTAMEHILEHHKLGKYMVQASTE--EKSSAPG-----PSRLTHFSSECALAQLLGLVANL 1400
            |:::.|:..    |:.:|...:..|.|.  |:..|.|     |....|...:..|.::..::..|
Zfish   923 STELERSWR----EYDRLEADVTLAKTNLLEQLEALGSPQTEPPSQKHVQIQKELWRIQDVMEAL 983

  Fly  1401 MCSGPALQPAELQCRQLDKSSLLSGGLQLLQPS----NPFDE-EKGEARSSHSC--------HST 1452
            ..:.|...|                     :||    ||... .|.|.....||        :|.
Zfish   984 SKNKPKRNP---------------------EPSFPGANPLSTLHKSEDSVDSSCVPPRPPLPYSY 1027

  Fly  1453 AGNTPTELPPPLPMQQQ-----LAPGR--------------GKSQLQLRADAFISGLAEARVS-- 1496
            .|.   :.|||||...|     ..|.|              |......:::..::.:||...|
Zfish  1028 EGG---DRPPPLPNPGQPHTTRTTPHRPEDRKTAQRNGTHTGPDYRLYKSEPELTTVAEVDESNG 1089

  Fly  1497 ----------EPPVAAWLALTERYCKAHNLMWHQEFATEHPVQELERLLSAVLIRHQYLGGLVLN 1551
                      |||     .:|:.......::..:   |:.|:.|...:.|.|.:|
Zfish  1090 EDKSEQTAEKEPP-----GVTKGIVYPVGVVSPR---TKSPMPESSTIASYVTLR---------- 1136

  Fly  1552 ALETEVPPPRQLGEIIR---LVHQ--AKWSVVRTR----QQLNRSYKEVCAPILERLR------- 1600
              :|:.|.||......|   .|.|  :...|.|||    :|:.|..:.....:.||.|
Zfish  1137 --KTKKPDPRTCQPQDRPRSAVEQMSSGAEVGRTRMSVEEQMERIRRHQQGALRERRREDGSLSR 1199

  Fly  1601 ---------FLLYEVR---PAISPQQRGLRR--LPILQRPPRFKMLVRRLLQELRSSRQPAKPED 1651
                     :...:.|   |.|||.::..||  .|:              .::.:.::.|...|:
Zfish  1200 SLSFTKDSTYYTLQARKKSPVISPDEQDERRDMTPV--------------ERDTKHTKHPDAEEN 1250

  Fly  1652 LLNASIQQEQEKKPQSMPKQELEEQEE---------EETLLRRLNERQIHGEGELDPALMQDIVD 1707
            .        ::.|.|......||.:::         :|:||:.::.:         |.|.||
Zfish  1251 C--------RDTKEQLPAHTHLEIKDKASVTRSVSMKESLLKSVSPK---------PVLKQD--- 1295

  Fly  1708 FALQDSCDVETARR-AMYCQMQRYQLRLAGLQ------------IVQQLLELHGLLDAAQYSLLN 1759
               :..|.:|..|: |....:|...:...|.:            .|||..:.:.|.::...:|::
Zfish  1296 ---ESECKLEYDRKLATQNSLQTAVMVRVGTEEDEEDEEEEQKDSVQQQEDSYELSNSKHSTLIS 1357

  Fly  1760 GFLGLHLKSTSSGGGSTG--SGSSLHVLGQLN 1789
            .  ....|:|||...|:.  |...||.|...|
Zfish  1358 A--SCDRKNTSSPSSSSDWKSRPLLHQLPNTN 1387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826	2/8 (25%)
		RCC1_2	828..857	CDD:290274	9/28 (32%)
		Cyt-b5	1290..1363	CDD:278597	18/79 (23%)
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
plekha5	XP_021330752.1	WW	13..42	CDD:306827
		WW	58..87	CDD:306827
		PH_PEPP1_2_3	177..280	CDD:270068
		SMC_N	822..>983	CDD:330553	42/238 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900