DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and wwc3

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001103940.1 Gene:wwc3 / 566492 ZFINID:ZDB-GENE-070209-229 Length:1148 Species:Danio rerio


Alignment Length:1080 Identity:212/1080 - (19%)
Similarity:351/1080 - (32%) Gaps:372/1080 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   911 VDLGEPTFRLLDQLLGMCSSQDNRQ--------------TPNQESECIAVACLNLFRL-QLLALI 960
            ::|.:...:|.:||    :..|||.              .|:|....||.....|.|| |.||.:
Zfish   130 LELAQQEMQLFNQL----TQDDNRSITSSHSGSSSNAKYDPDQIKAEIACRRERLSRLKQELAQM 190

  Fly   961 ANGVEPRQVG---LASGSRLLCSLKTRILGLAGGSQV---LRTIQVA---AQQALQDGWSVLLPT 1016
            ...::.:::|   |....|.:.|.:|. ..|.....:   ||:|:.|   .::..||....|...
Zfish   191 RQELQYKEMGVETLQEIDRKMSSSQTN-YKLDEAQAIFSELRSIKKAISTGEKERQDLIQSLAKL 254

  Fly  1017 AAERAQTLTSLLPSEPGQASSAGHRFMTDL-LVSSLMAEGGLE---------------------- 1058
            ......::..:..:....|.|...:..||. ..:.||.|.|.:                      
Zfish   255 TLNFCDSINEVTNNAESLADSCSVQQYTDAGCQTDLMGEFGSQESSLLADRVKLSWQYEEAKKKM 319

  Fly  1059 SALQHAI-RLESSSCSA--------DCGDGVHLPLLQLITRLLSNNAALSQTR-LSPTLGKQQEK 1113
            |::||.: :|:|.|.|.        ||     |.||:....||.....|||.: .|.||.:.||:
Zfish   320 SSIQHQLAQLDSESWSGRAEADRDWDC-----LQLLREKETLLQELTLLSQQQHSSDTLLQLQEE 379

  Fly  1114 E---EEEREQQHQEPSTSPSLSLLHRFQRLLLS---HIHQAQPEEETTGAEALLLQYMHALIPA- 1171
            :   ::|.::.|...|...:       ||:||.   ::...|.||.|.     :..|:|:.:.: 
Zfish   380 KRRLQDEVQRAHSAQSQGAN-------QRILLQEKRNVLMRQLEEATR-----ITTYLHSQLKSL 432

  Fly  1172 -----CVATLQKAHELALQCREPGENSFGQMVGHLGRVLQADISDALLNELLVGLLLLKRDR--- 1228
                 .|::......||        :|.|.:....|.:.....:|      :.||....|..   
Zfish   433 SASNLTVSSSSSRGSLA--------SSRGSLASSRGSLSSVSFTD------IYGLPQYDRTEGSS 483

  Fly  1229 ----PQCLGGLRWARLFLPLLRVLDRLNRALGEGELRDGD-DMGWPGIICRGGPKGGPPPADP-E 1287
                |.       .|..||    |:..:.....|..|..| ......:..|.......||:.| :
Zfish   484 DVLDPS-------FRYLLP----LESHSSGSAYGPKRSHDTPQSLTSLSSRSSLSSLSPPSSPMD 537

  Fly  1288 THY-----------VRRADME----NLLLDGSRCIILAGYVCDLSG------------------- 1318
            |.|           :....||    .||.:|.|....|.....|||                   
Zfish   538 TPYHSAPQDCPLAQMTEEYMEVASRGLLAEGLRTQSQAQQHTTLSGDGEVGIAATAHLLEGKSHR 602

  Fly  1319 --------------YNCESETLRS---------------VLDSGL-----------------GKD 1337
                          ..|:|.:..|               ..|||:                 .:|
Zfish   603 DAALQGTHSSTGVTLRCKSASRTSRRARRVSAGVNEDVLATDSGVFEAWSRSRTEESEEVSFAQD 667

  Fly  1338 LTAEMSSQVH-----------RTAMEHILEHHKLGKYMVQASTEEK-------------SSAP-- 1376
            :|..:|..||           |..:.|:|:...|.|    ||..::             ||.|  
Zfish   668 VTVAVSEPVHIQIGLLYDSNSRFLLLHVLQMRNLSK----ASIRDRWKVFVKVHVLPMDSSRPCT 728

  Fly  1377 -------GPSRLTHFSSECALAQLLG------LVANLMCSGPALQPAELQCRQLDKSSLLSGGLQ 1428
                   .|..|..|:....:...:|      |..:|...||..|...|...|:..:..: |..:
Zfish   729 YYCCKAQEPQSLLSFNESFRIPLSVGGPGAHALQFSLSTLGPLAQEELLGSAQVSLTDCV-GSTE 792

  Fly  1429 LL----------------------QPSNPFDEE----KGEARSSHSCHSTAGNTPTELP-PPLPM 1466
            :|                      ||:...|||    :|:.:...|..|.......||. ....:
Zfish   793 MLFQWLKVQFHSTENHRPEHRRLSQPNRIMDEEEEKNEGQGKLEVSVVSHLEEMKKELQRSEEEL 857

  Fly  1467 QQQLAPGRGKSQLQLRADAFISGLAEARVSEPPVAAWLALTERYCKAHNLMWHQEFATEHPVQEL 1531
            :::..||...|:...:|::..||.:.:.....|....|. .|..|........|. |..:|:.::
Zfish   858 ERKEEPGEAVSERSWQAESVDSGCSNSTAFVIPCPESLC-GEGICLTSGRRCLQP-AERNPIIKV 920

  Fly  1532 ERLLSAVLIRHQYLGGLVLNALETE--------VPPPRQLGEIIRLVHQAKW----SVVRTR--- 1581
            ::                  |..||        :.|..:.|   |..|.:.:    ::||::   
Zfish   921 DK------------------ATNTEGVFAEPMRMRPKERTG---RWGHSSPFMRSSTIVRSQTFS 964

  Fly  1582 -----QQLNRSYKEVC--------API----LERLRFLLYEVRPAISPQQRGLRRLPILQRPPRF 1629
                 |.:.|.|:...        :|.    ||| |.|.|:       ||.  .|..:.::|.|.
Zfish   965 PGARSQYVCRLYRSDSDSSTLPKKSPFIRNTLER-RTLRYK-------QQS--HRSSLAEQPTRT 1019

  Fly  1630 KMLV-----------RRLLQELRSSRQ-----------PAKPEDLLNASIQQEQ----EKKPQSM 1668
            .:.:           |:|.:||.:.|:           |..|.||.:.:::.|:    .::.|..
Zfish  1020 SLDLELDLQACRTRQRQLTEELAALRELKLRLEEPMQGPRGPADLPHWALRDERFRNLLREAQRQ 1084

  Fly  1669 PKQELEEQEEEETLLRRLNER-----QIHGEGELDPALMQ 1703
            .||..:||.:||...|||.:.     |:.|:...:|..:|
Zfish  1085 SKQTRQEQRQEEAAERRLRKASKEVLQMRGQSHKEPLPVQ 1124

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597 26/163 (16%)
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
wwc3NP_001103940.1 WW 17..46 CDD:278809
WW 64..93 CDD:278809
C2_Kibra 677..800 CDD:176062 24/127 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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