DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and wwp2

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_005163228.1 Gene:wwp2 / 564527 ZFINID:ZDB-GENE-000607-82 Length:867 Species:Danio rerio


Alignment Length:325 Identity:90/325 - (27%)
Similarity:147/325 - (45%) Gaps:61/325 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly  4600 AGANRDCFLLDPTLSSVL--QMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPT--D 4660
            ||.|..|..::|. ||:.  .:..|||:|..:.:|:..|..:......|.::::..:  :||  |
Zfish   579 AGKNNYCLQINPA-SSINPDHLTYFRFIGRFIAMALYHGKFIDTGFTLPFYKRMLNK--KPTLKD 640

  Fly  4661 LTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTSSARGHEVPLSTRYTH----------ISPRN 4715
            |..:|.::...::.::..|.:.   ..:||.|    |:..|: |....||          ::..|
Zfish   641 LESIDPEFYNSIMWVKENDLEE---CGVELYF----AQDMEI-LGKVTTHQLKDDGENELVTQDN 697

  Fly  4716 RAEYVRLALGFRL-HEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVAT 4779
            :.||:.|...:|. ...:||.||..||.::|:|:..|..|...||:.|:||..:|.|...:....
Zfish   698 KEEYIGLLTDWRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDLNDWQKNTI 762

  Fly  4780 YKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNPPDHF- 4843
            |:.:..:|..:.|||:|::|..|::|...|:||.|..|||  :..|      .:::..|.|..| 
Zfish   763 YRHYTKNSKQIHWFWQVVKEMDNEKRIRLLQFVTGTCRLP--VGGF------AELIGSNGPQKFC 819

  Fly  4844 ---------LPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSIDTDEYARVAMGEPTEATGSE 4899
                     ||.|:|||..|.:|.|.....|.|||.:||                 |.||..|.|
Zfish   820 IDKVGKETWLPRSHTCFNRLDLPPYKNLEQLREKLLFAI-----------------EETEGFGQE 867

  Fly  4900  4899
            Zfish   868  867

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033 85/304 (28%)
HECTc 4553..4878 CDD:214523 85/302 (28%)
wwp2XP_005163228.1 C2_E3_ubiquitin_ligase 17..145 CDD:175988
WW 298..327 CDD:197736
WW 328..357 CDD:278809
WW 403..431 CDD:278809
WW 441..473 CDD:197736
HECTc 513..865 CDD:238033 88/321 (27%)
HECTc 536..864 CDD:214523 88/320 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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