DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and smurf2

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001107898.1	Gene:	smurf2 / 563633	ZFINID:	ZDB-GENE-030131-1830	Length:	765	Species:	Danio rerio

Alignment Length:	765	Identity:	172/765 - (22%)
Similarity:	275/765 - (35%)	Gaps:	209/765 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  4244 DIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGC--KLPYKIESLAGLGVVKVECGSQFS 4306
            |:..|..|:.|:.:        |......|....|..||  .|...|..|...|..::
Zfish    66 DLYIGKSDSITISV--------WNHKKIHKKQGAGFLGCVRLLSNSINRLKDTGYQRL------- 115

  Fly  4307 VALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWG 4371
                           |.::||....|.| |.:.|.:||.:..|......:.|....|:.....|
Zfish   116 ---------------DLNKLGPNDSDTV-RGQIVVSLQSRDRIGSGGPVVDCSRLFDNDLPDGW- 163

  Fly  4372 DNDEGQLGDGTV---------TAIQRP-----------RLVAALQGKHIVKVTCGSAHTLALSTS 4416
              :|.:...|.:         |..:||           |.::.|..::...:|...|..:.....
Zfish   164 --EERRTASGRIQYLNHITRSTQWERPTRPASEYSSPGRPLSCLVDENTPIMTPNGAAGVPADDP 226

  Fly  4417 QLSE-RLRP-----------LPNPPLEYDLVRDLAPEALHAR------LILLH------------ 4451
            ::.| |:|.           |..||       || ||....|      :..||
Zfish   227 RVQERRVRSQRHRNYMSRTHLHTPP-------DL-PEGYEQRTTQQGQVYFLHTQTGVSTWHDPR 283

  Fly  4452 ---HFSELVCPCLAMLPISGDLSLGALKDVLVYNIKEAAFRKVI------QTTMVRDKQHGPVIE 4507
               ..|.:.|..|..||..             :.|:..|..:|.      :||...|.:....:.
Zfish   284 VPRDLSNVNCEELGPLPPG-------------WEIRNTATGRVYFVDHNNRTTQFTDPRLSANLH 335

  Fly  4508 L--------NRIQVK-RSRNRCNGLAGIDGMKSVFG------------------QMVQKLPLLTQ 4545
            |        :|..|: :|.:|...|.  :..:||..                  .:||||.:|.|
Zfish   336 LVLNPSPNGSRAAVEAQSSSRPGQLK--EQAQSVVSPGNLPEDPECLTVPKYKRDLVQKLKILRQ 398

  Fly  4546 E----------------------------ALALPHRVWK---VKFVGESVDDCGGGYSESIAEMC 4579
            |                            ....|..:||   |||.||...|.||...|.:..:.
Zfish   399 ELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMVKFRGEEGLDYGGVAREWLYLLS 463

  Fly  4580 DELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVL---QMNMFRFLGVLMGIAVRTGSPLSI 4641
            .|:.|....|.         ..:..|.:.|.....|.:   .::.|.|:|.:||:||..|..:..
Zfish   464 HEMLNPYYGLF---------QYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDG 519

  Fly  4642 NLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTS-SARG----HE 4701
            ....|.::||.|:.:...|:..||.|....|:.|  :|:|  :...|:..|... :|.|    ||
Zfish   520 GFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWI--LDND--ITGVLDHTFCVEHNAYGEIIQHE 580

  Fly  4702 VPLSTRYTHISPRNRAEYVRLALGFR-LHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCG 4765
            :..:.:...::...:.|||||.:.:| |...:.|..|::.|.::|||..||..|...||:.:|||
Zfish   581 LKPNGKSIPVTQDTKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKAFDEKELELIVCG 645

  Fly  4766 SPDIPLGLLKSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRG--- 4827
            ...|.:...||....|...|.|.:|.|||..:|.:..:.|:..|:||.|.:|:|  :..|:.
Zfish   646 LGKIDINDWKSNTRLKHCTPDSNIVKWFWRAVESYDEERRARLLQFVTGSSRVP--LQGFKALQG 708

  Fly  4828 ----RDFVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAI 4873
                |.|.:..::.:..:  ||:::|||..:.:|.|.....|.:||..||
Zfish   709 AAGPRLFTIHQIDASTNN--LPKAHTCFNRIDIPPYESYDKLYDKLLTAI 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826	4/12 (33%)
		RCC1	4260..4309	CDD:278826	9/50 (18%)
		RCC1	4312..4360	CDD:278826	11/47 (23%)
		RCC1	4364..4413	CDD:278826	10/68 (15%)
		HECTc	4509..4880	CDD:238033	112/431 (26%)
		HECTc	4553..4878	CDD:214523	97/340 (29%)
smurf2	NP_001107898.1	C2_Smurf-like	13..137	CDD:176028	20/101 (20%)
		WW	159..188	CDD:278809	4/31 (13%)
		WW	252..283	CDD:197736	7/31 (23%)
		WW	298..330	CDD:197736	8/44 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..375		7/35 (20%)
		HECTc	410..762	CDD:238033	98/364 (27%)
		HECTc	437..762	CDD:214523	96/337 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810