DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and hectd3

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001070627.2 Gene:hectd3 / 563189 ZFINID:ZDB-GENE-031118-179 Length:854 Species:Danio rerio


Alignment Length:1067 Identity:253/1067 - (23%)
Similarity:400/1067 - (37%) Gaps:336/1067 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  3918 FKRYCIAVRVAQSLIRRTE-LPRAFCL---EVRKKFAEMLPSSSSNSNANPGCQSPGASMLNSTT 3978
            |...||      ...|::| ||.:.|.   ||..|..:...|.|::::::....|.|.|:::...
Zfish    16 FLNRCI------ECFRKSEPLPESLCYVAKEVCYKICKDSSSGSTSASSSTAGNSGGKSVVSVWD 74

  Fly  3979 S-----LSSSTVSNVSPPPG----ITGEQPDLHCHAHQL--ESTSTLLHEDHTLFQAPHDAQLLQ 4032
            |     ...|...|:.|..|    .|||:   :|::|.|  :.....|.|    ::|..|.:   
Zfish    75 SPHQAPHKKSCRCNIEPKKGTCIRTTGEE---YCNSHGLWVKINKEQLEE----YRAGVDIE--- 129

  Fly  4033 WLNRRPDDWAL----SWGG--------ASTIYG----WGHNHRGQLGGLEGSRIKTPTPCEALSL 4081
                  :.|.|    :.||        |.||..    :|::|:               ||.    
Zfish   130 ------EGWILVCKHTEGGDRLVPVESADTISRQQQLFGYDHK---------------PCN---- 169

  Fly  4082 LRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTL------------------- 4127
             |..|:...|.||.              .|.:..|..:|..|:..|                   
Zfish   170 -RWEQVVDVENSLH--------------MGAKPKVAEADEAAVRKLRYVPPTWTFECDEDLVHYF 219

  Fly  4128 ----------LGSLQHVFVKKVAVN------SGGKHCLALTTEGEVYAWGEGEDGKLG-HGNRMS 4175
                      |||::.. |..:.|:      |||..||   |:|:...:.| .||..| |..|:.
Zfish   220 YDHIGKEDENLGSVKQC-VTSIDVSSSSEDPSGGASCL---TDGDTETYWE-SDGMQGQHWIRLH 279

  Fly  4176 YDRPKLVEHLNGMSVADIACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGY 4240
            ..|..:|..|                       :||          ...::|...||        
Zfish   280 MRRGTVVNKL-----------------------ILT----------VDSTDDNYMPK-------- 303

  Fly  4241 RAIDIACGSGD--AQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKV---E 4300
             .:.:..|.||  .:...:|.||.:          :|    :.|.|.   :..:.|.|::|   |
Zfish   304 -RVTVYGGEGDNLKKYSDVTIDDTL----------IG----EVCVLE---DMTSHLPVIEVRIEE 350

  Fly  4301 CGSQFSVALTKSGAVYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSG 4365
            |..:                         .:| ||       ::|.||.|         :|    
Zfish   351 CRDE-------------------------GID-VR-------IRGLKIKS---------SC---- 369

  Fly  4366 EVYTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLPNPPL 4430
                  :.|.|...|    ..|.|.||                                      
Zfish   370 ------ERDLGLNAD----VFQSPNLV-------------------------------------- 386

  Fly  4431 EYDLVRDLAPEALHARLILLHHFSELVCPCLAMLPISGDLSLGALKDVLVYNIKE----AAFRKV 4491
            .|..:....|:.|:.|.:::..|..|:...|..:..:.|.|||....  :.:||:    :..|..
Zfish   387 RYPRLEGTPPDVLYRRALVIQRFITLLDSLLPHMVPAWDYSLGTFNQ--IKSIKQFLLLSKRRSA 449

  Fly  4492 IQTTMVRDKQHGPVIELNRIQVKR---SRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPHR 4553
            :.|..::|.:......:.|:.:.|   ..:|.|....:....:|..|:.:.|....:....|.:|
Zfish   450 LITQCLKDSETSKPNFMPRLYINRRLAMEHRDNPTLDVTCKNAVLTQVYEGLKPSDKYEKTLDYR 514

  Fly  4554 -------VWKVKFVGESVDDCGGGYSESIAEMCDELQNGS------VPLLINTPN-GRGEAGANR 4604
                   .|:.||:.|.:.|.|||:.:|:|:|.:||...|      :|....|.| |.|||   |
Zfish   515 WSARYDQWWECKFIAEGIIDQGGGFRDSLADMSEELCPSSSECPLPLPFFTRTSNQGAGEA---R 576

  Fly  4605 DCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPT-DLTEVDRDY 4668
            |.::.:|   |..:.|.|.::|.|||.|:|....|.:.|...||:||.||.:..| |...||...
Zfish   577 DFYVPNP---SCREFNKFEWIGQLMGAALRGKDFLVLALPGLVWKQLIGEAVSWTKDFPAVDSVL 638

  Fly  4669 VAGLLCIRNMDDDPKLFT-ALELPFSTSSARGHEVPL-------STRYTHISPRNRAEYVRLALG 4725
            |..|..:.:||.:...|. ..||.::|..:.|..|.|       ..||     .:|.|::||...
Zfish   639 VKLLEAMDHMDKETFDFKFGQELVYTTPLSDGRLVELIPGGSGVVVRY-----EDRVEFIRLVQK 698

  Fly  4726 FRLHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKGFDPSSALV 4790
            .||.|..||:.|::.|:.||:|..:|.|.:..|::..|||.|:|.:..||.:..|:..:.:...|
Zfish   699 ARLEENREQISAMQAGLVKVVPQAVLDLLTWQEVEKKVCGDPEITVEALKRLTRYEDLEQTDVRV 763

  Fly  4791 TWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNPPDHFLPESYTCFFLLK 4855
            .:.||.:..|||::||.|||||.||:|||..|       ::....:.:..:..||:|.||...|.
Zfish   764 QYLWEALMNFTNEDRSRFLRFVTGRSRLPAPI-------YIFPDKQGSETEDALPQSSTCSSTLY 821

  Fly  4856 MPRYSCKAVLLEKLKYAIHFCKSIDTD 4882
            :|:|....|..|||:||.:.|.:||||
Zfish   822 LPKYPSAKVCEEKLRYAAYNCVAIDTD 848

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 10/35 (29%)
RCC1 4154..4203 CDD:278826 10/49 (20%)
RCC1 4206..4257 CDD:278826 8/52 (15%)
RCC1 4260..4309 CDD:278826 10/51 (20%)
RCC1 4312..4360 CDD:278826 7/47 (15%)
RCC1 4364..4413 CDD:278826 7/48 (15%)
HECTc 4509..4880 CDD:238033 126/396 (32%)
HECTc 4553..4878 CDD:214523 118/347 (34%)
hectd3NP_001070627.2 APC10-HECTD3 231..366 CDD:176487 44/231 (19%)
HECTc 523..842 CDD:214523 116/336 (35%)
HECT 561..838 CDD:279026 100/294 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.920

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