DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and yap1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001132952.1 Gene:yap1 / 561411 ZFINID:ZDB-GENE-030131-9710 Length:442 Species:Danio rerio


Alignment Length:583 Identity:114/583 - (19%)
Similarity:176/583 - (30%) Gaps:238/583 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly  3762 GESGSD-----RAVLS------QPSMAL-VMSLLDSRLAPRQPSVLLRLASALA----------- 3803
            |:|.:|     .||::      .||:.: :..|.||...|.:|....|.||..|           
Zfish    19 GDSETDLEALFNAVMNPKNTIVPPSVPMRLRKLPDSFFTPPEPKSHSRQASTDAGTAGTVTPHHV 83

  Fly  3804 ------ACSQLGALTTAQRIWSLRKLHAVLLLEQAPRPQDPSLSTLLQP--LIPELLRQYEYEEP 3860
                  |..||||::                         |...|.:.|  ..|:.|||..||.|
Zfish    84 RAHSSPASLQLGAVS-------------------------PGALTSMGPANAPPQHLRQSSYEIP 123

  Fly  3861 ------------QVRGG--IHLMHSDYFKT----LAALACDMQLDAALPATS--------SSSSS 3899
                        :...|  ..|.|:|...|    ..||   :|::.|.||:.        .:.:|
Zfish   124 DDMPLPPGWEMAKTPSGQRYFLNHNDQTTTWQDPRKAL---LQMNQAAPASPVPVQQQNIMNPAS 185

  Fly  3900 SAAPG----AISSTGDV----HK---WAWFKRYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEML 3953
            ...|.    ||:|.|::    ||   .:|..                  ||     :..:||...
Zfish   186 GPLPDGWEQAITSEGEIYYINHKNKTTSWLD------------------PR-----LDPRFAMNQ 227

  Fly  3954 PSSSSNSNANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGI-TGEQP----DLHCHAHQLESTST 4013
            ...|.::....|.|.|.                  ||..|: :|..|    .:|....:|.....
Zfish   228 QRISQSAPVKQGSQLPS------------------SPQSGVMSGNNPIRLQQIHIEKERLRIKQE 274

  Fly  4014 LLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGLEGSRIKTPTPCEA 4078
            ||.:                   ||.:.||               |.||          ||..|.
Zfish   275 LLRQ-------------------RPQELAL---------------RNQL----------PTSMEQ 295

  Fly  4079 LSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGR-LGVGGSDSWAIPTLLGSLQHVFVKKVAVN 4142
                     .||.|:        .:.:.|.|...| :....||    |.|.....|  .:..:.:
Zfish   296 ---------DGGTQN--------PVSSPGMGQDARNMTTNSSD----PFLNSGTYH--SRDESTD 337

  Fly  4143 SG---GKHCLALTTEGEVYAWGEGEDG-KLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHSAAI 4203
            ||   ..:.:..|.:..:.:..|.|.| .||.|: |:....:..::|:.:...|:..|:....::
Zfish   338 SGLSMSSYSVPRTPDDFLNSVDEMETGDTLGPGS-MATQPSRFPDYLDAIPGTDVDLGTLEGESM 401

  Fly  4204 TASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDNVWSW 4266
            ...|                   ::|.|.|.|||    :.||.............|.:|..:|
Zfish   402 AVEG-------------------EELMPSLQEAL----SSDILNDMESVLAATKIDKENFLTW 441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 5/32 (16%)
RCC1 4154..4203 CDD:278826 10/49 (20%)
RCC1 4206..4257 CDD:278826 9/50 (18%)
RCC1 4260..4309 CDD:278826 2/7 (29%)
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
yap1NP_001132952.1 FAM181 <41..186 CDD:291891 37/172 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..89 9/37 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 97..116 4/43 (9%)
WW 127..158 CDD:197736 5/30 (17%)
WW 188..217 CDD:278809 8/46 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 230..254 7/41 (17%)
Transactivation domain. /evidence=ECO:0000250|UniProtKB:P46937 247..442 53/286 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 286..374 27/121 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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