DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and herc5.1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_017211386.1 Gene:herc5.1 / 559981 ZFINID:ZDB-GENE-090311-56 Length:884 Species:Danio rerio


Alignment Length:931 Identity:216/931 - (23%)
Similarity:371/931 - (39%) Gaps:190/931 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  4075 PCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGV----GGSDSWAIPTLLGSLQHVF 4135
            |.:.|...:.:|:|.|:|...|:|.||:||..|..:.|:||:    .|:.|   |..|.||..:.
Zfish     3 PLKGLENRQVIQIACGDQHSMALTNDGQLFVWGENALGQLGLRKEQAGTQS---PRHLQSLCGIP 64

  Fly  4136 VKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADIACGSAHS 4200
            |.:  :::||.|...|:..|.|:.||....|:||.|:......|.:|..|....:..|:||..|:
Zfish    65 VAQ--ISAGGNHSFVLSLSGVVFGWGGNSAGQLGLGDTTDRFVPTVVNSLKRKKIVSISCGGEHT 127

  Fly  4201 AAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCITDDDN-VW 4264
            ||:...|.|.|:|.|.:|:|||...:|:..|:||..|.|.:...:.||..  .||..|.... ::
Zfish   128 AALAKGGTVFTFGSGGFGQLGHNSFKDEHHPRLVAELWGSKVSQVTCGRN--HTLVSTASPKLIY 190

  Fly  4265 SWGDGDYGKLGRGGSDGCKLPYKIESLAGLG----VVKVECGSQFSVAL-----------TKSGA 4314
            |:|.|..|:||.|......:|..::......    :.|:..|...|.||           ..:..
Zfish   191 SFGCGMQGQLGNGEQVKQSVPLPVDQPTEYNDEYTIQKLVAGENHSFALYFKELGNEANPDPTRG 255

  Fly  4315 VYTWGKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIA---TGSLHCVACSDSGEVYT---WGDN 4373
            :.|:..|...:...|     :.|:| |....||:.|.|   .||.  :.....|...|   :...
Zfish   256 IMTFDNGMIEQCECG-----KDPRK-AIKDLKKVFSSAASLNGSF--LKTRHDGHYQTSEEYCGL 312

  Fly  4374 DEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPL--PNPPLEYDL-- 4434
            |.|.:.....|..:..||::.     ::||              |.|.|.|.  |||..|..|  
Zfish   313 DFGLVESSIATLSRNERLIST-----VLKV--------------LQESLLPTLNPNPTGEESLRL 358

  Fly  4435 --------------------------VRDLAPEALHARLILLHHFSELVCPCLA-MLPISGDLSL 4472
                                      :.:|:|.||.   :|..::|:|....|. ::.:....|.
Zfish   359 YILLPELISHLKSEQKAELTEALASKILNLSPAALR---VLEIYWSKLPDDWLKNLVKLFKKASA 420

  Fly  4473 GALKDVLVYNIKEAAFRKVIQTTMVRDKQHGPVIELNRIQVKRS--------------------- 4516
            .....::|.|:...|...:::...:..:.:......||...||.                     
Zfish   421 KFFGRIIVENVNNVAKTHMLKFVEILQRVYQVCCSANRNIKKRYFIIHEVNNLLDVLQTMNADVN 485

  Fly  4517 -----RNRCNGLAGIDGMKSVFGQMVQKLP----LLTQEALA--LPHRVWKVKF---VGES--VD 4565
                 .|....:..::..::.:.:..:||.    :...||..  :.:||||.:|   |..:  ::
Zfish   486 NNWPWFNLTGQIHALEAQRNAYEETFRKLTSFPCIFNLEAKCSYMRNRVWKGRFELTVRRTALLE 550

  Fly  4566 DC----GGG-------------YSESIAEMCD------------ELQNGSVPLLINTPNGRGEAG 4601
            ||    ..|             ::|::::..|            ||.:.:..|.:...|      
Zfish   551 DCLCLLNPGTQQHLRDKWLSILFTENVSKRTDVHKRDFFLNVFKELCDPASQLFMYNDN------ 609

  Fly  4602 ANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPT--DLTEV 4664
               :..:..|...:|.:...|.| |:|.|:|....|.:::.....::::|..  ::|:  |..|.
Zfish   610 ---ETMIWFPAKLTVEKKKYFLF-GILCGLAFNNSSVVNLPFPLALFKKLLN--IKPSLEDFIEF 668

  Fly  4665 DRDYVAGLLCIRNMDDDPKLFTALELPFSTSSARGHEVPL--STRYTHISPRNRAEYVRLALGFR 4727
            :..:...|..|....:|....::|.|....|   |.|:.|  :....||:..||.::|...:.  
Zfish   669 NPVHGRSLQYILEYSNDVLEESSLPLTIIWS---GSELDLDPAEPEQHITTSNRTKFVDEYVD-- 728

  Fly  4728 LHEFDEQVKAV----RDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKG-FDPSS 4787
             |.|::.||..    |.|..:.....|:.:|...||:.::.|:.:....:||...||:| |:...
Zfish   729 -HIFNQSVKEAFEEFRRGFFRGCEKRLVEMFEPEELRGVLVGNEEYDWNILKQNTTYEGVFNADH 792

  Fly  4788 ALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQVLEKNPPDHFLPESYTCFF 4852
            .::..||||.::.|..|:..||.|:.|..|:|  |.........:..|..:..|| |||:.||..
Zfish   793 PVIISFWEVFDDLTPNEKKSFLLFLTGFERVP--ILGMSAVKMRVTHLANSTEDH-LPETLTCHS 854

  Fly  4853 LLKMPRYSCKAVLLEKLKYAI 4873
            ||::|:|..:..|..|:..||
Zfish   855 LLQLPKYEKRETLRAKVIEAI 875

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 9/29 (31%)
RCC1 4154..4203 CDD:278826 16/48 (33%)
RCC1 4206..4257 CDD:278826 19/50 (38%)
RCC1 4260..4309 CDD:278826 11/53 (21%)
RCC1 4312..4360 CDD:278826 12/50 (24%)
RCC1 4364..4413 CDD:278826 9/51 (18%)
HECTc 4509..4880 CDD:238033 97/440 (22%)
HECTc 4553..4878 CDD:214523 88/364 (24%)
herc5.1XP_017211386.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.820

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