DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and nedd4l

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_021324687.1 Gene:nedd4l / 559634 ZFINID:ZDB-GENE-051118-2 Length:1279 Species:Danio rerio


Alignment Length:1568 Identity:324/1568 - (20%)
Similarity:525/1568 - (33%) Gaps:511/1568 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  3508 SGGANTLPPLSAGPLSAFQSLTGSLSMSGSL---SSSALPQHKHSRMSASAMSVMAATMTQQEEM 3569
            ||.:||.|.|        :.|.|::...|.:   |:.|:..|...|....|.|....|:...:..
Zfish    11 SGRSNTAPEL--------EELNGTVEEEGDISYNSTGAMVVHAQPRNGGHAESPEPGTVVGSDAS 67

  Fly  3570 LSHISHCHGLDDFGGLLGEPEAKSLVELLKLAVCGRCGPPSTSQTIADTLISLGAGTPAVAAMLL 3634
            |...|...    ...|.|:.|:::              ..|||..|:                 |
Zfish    68 LKRSSSMF----IPQLQGQAESRT--------------TKSTSVQIS-----------------L 97

  Fly  3635 ETCITELEDLCTSRHCLGKLPKPVM-QESSHPYVDNVNVTGVVRIPGAEMLRL----EFDSQC-- 3692
            :......||      .|...|.|.. |:.:.||.:          || |.|.|    .:...|  
Zfish    98 QRTTAPHED------ALPFDPPPAYPQDPAPPYTE----------PG-ESLPLPPPPTYYKSCQN 145

  Fly  3693 --STEKRNDPLVIMDGTGRVLAMR--SGRE-FAHWAPE-IRVLGDELRWKFSSDSSV-------- 3743
              .|:|..:|      ..:|..:|  .|:. :.|..|: |.:.|..:|.:.:..|.|        
Zfish   146 VEQTQKDTEP------KRQVFCVRPCDGQNGYTHGNPQGITIGGVCIRRRSADGSDVQQFRIMPY 204

  Fly  3744 -----NGWGWRFWVHAIMPAATLGESGSDRAVLS-------QPSMALVMSLLD--------SRLA 3788
                 ||..|     ::...:..| .|:.|.:..       |||......:.|        |||.
Zfish   205 SEDGHNGHNW-----SVQQCSDRG-PGAQRLIFQLQKDQGRQPSSTSQPDVSDLGITGSKGSRLV 263

  Fly  3789 PRQPSVLLRLASALAACSQLGALTTAQRIWSLRKLHA-------------------VLLLEQAPR 3834
             |.|.:.|..:::    ..|.......|:.|:..|||                   ...:.:...
Zfish   264 -RYPRIRLERSTS----QPLQPRGAPSRLGSMPNLHAPISEMETESDFIENGAQGCTFKIRKEQN 323

  Fly  3835 PQDPSL----------STLLQPLIPELLRQYEYEEPQVRGGIHLMHSDYFKTLAALACDM--QLD 3887
            .|.|..          |.:|:..| .:.:......||...|:....:.:|.. .....|.  |:|
Zfish   324 SQQPKFKIYFSQGGEHSPILERNI-SIGKAPTCSNPQAHIGLDRPKNGHFNN-GQTRDDFLGQVD 386

  Fly  3888 AALPATSSSSSSSAAPGAISSTGDVHKWAWFKRYCIAVRVAQSLIRRTELPRAFCLEVRKKFAEM 3952
            ..|....:...:...|..            ||.:.:..|..:|.::.         .:|.|.| .
Zfish   387 VPLTHLPTEDPAMERPYT------------FKDFLLRPRSHKSRVKG---------YLRLKMA-Y 429

  Fly  3953 LPSSSSNSNANPGC--QSPGASMLNSTTSLSSSTVSNVSP-PPGITGEQPDLHCHAHQLESTSTL 4014
            ||.:..:...:...  ::.|..:.:||...|......:.| ||| ..|:.|      .|..|..:
Zfish   430 LPKNGGHEEESGEMREEAEGWEVTDSTDPGSQRPQQLLPPLPPG-WEEKVD------NLGRTYYV 487

  Fly  4015 LHEDHT-----------LFQAPHDAQLLQ--------WLNRRP---------------DDWALSW 4045
            .|.:.|           :.:..:|.||.|        :.:||.               ||   ||
Zfish   488 NHNNRTTQWKRPSSVDVVSETENDNQLRQINQEAHRVFRSRRHISEDLENEQLDIRDIDD---SW 549

  Fly  4046 GGAS----TIYGWGHNHRGQLGG---LEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPD--- 4100
            ...|    |:...|.||  .|.|   |......||...:.:||            ..::.||   
Zfish   550 EPISEEDPTLLTDGLNH--SLSGPSSLAMPLSSTPDFSDEISL------------RLSLAPDTNG 600

  Fly  4101 ---GKLFATGYGSGGRLGV-----GGSDSWAIPTLLGSLQHVFVKKVAVNSGGKHCL------AL 4151
               |...|.......||..     |.||....||...|.|....:...| :|.:..:      ||
Zfish   601 EIPGPSSAVQSHLSSRLRSSSMTDGVSDQAQPPTPTQSSQTRRTRAQTV-TGVEDTMSPSASYAL 664

  Fly  4152 TTEGEVYAWGEGEDGK-----LGHGNR-MSYDRPKLVEHL-NGMSVADIACGSAHSAA------I 4203
            ||.|....|.|.:|.|     :.|.|| .::.||.|.:|. :|.|.:..|.|.|.:|.      .
Zfish   665 TTPGLPPGWEERKDPKGRTYYVNHNNRSTTWTRPILQQHTEDGASTSVAAVGGATAATPPASTPS 729

  Fly  4204 TASGHVLTWGKGRYGRLGHGDSEDQL-RPKLVEALLGYRAIDIACGSGDAQTLC--ITDDDNVWS 4265
            |:|||:               ||.|: ||:.:              |....||.  :...:||  
Zfish   730 TSSGHL---------------SEPQVRRPRSL--------------SSPTVTLSSPLEGANNV-- 763

  Fly  4266 WGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYT-----W------- 4318
                   .:.|...|....|...:.            |.:|...|:..|..:     |       
Zfish   764 -------PIRRAVKDTFSNPQSPQP------------SPYSSPKTQHKANQSFLPPGWEMRIAPN 809

  Fly  4319 GKGDFHRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTV 4383
            |:..|       :||                              :....||.|           
Zfish   810 GRPFF-------IDH------------------------------NSRTTTWED----------- 826

  Fly  4384 TAIQRPRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLPNPPLEYDLVRDLAP---EALHA 4445
                 |||...:..:....:..|.              |.||||.|.|        |   |.:||
Zfish   827 -----PRLKYPVHMRTKASLDPGD--------------LGPLPNLPEE--------PGWEERVHA 864

  Fly  4446 --RLILLHHFSE--------LVCPCLA--MLPISGDLSLGALKDVLVYNIKEAAFRKVIQTTMVR 4498
              |...:.|.::        |..|.:.  .:|.|.:           :..|...|||        
Zfish   865 DGRTFYIDHNNKKTQWEDPRLQSPAITGPAVPYSRE-----------FKQKYDYFRK-------- 910

  Fly  4499 DKQHGPVIELNRIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVWKVKFVGES 4563
             |...|....||.::|..||            ::|.:..:::..|.:.. :|..|:| ::|..|.
Zfish   911 -KLKKPADIPNRFEMKLHRN------------NIFEESYRRIMSLKRPD-SLKARLW-IEFESEK 960

  Fly  4564 VDDCGGGYSESIAEMCDELQN-----------GSVPLLINTPNGRGEAGANRDCFLLDPTLSSVL 4617
            ..|.||...|....:..|:.|           .:..|.||..:|.    .|.|            
Zfish   961 GLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGL----CNED------------ 1009

  Fly  4618 QMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDP 4682
            .::.|:|:|.:.|:||..|..|......|.::.:.|:.:...|:..||.:|...|..|  :::||
Zfish  1010 HLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWI--LENDP 1072

  Fly  4683 KLFTALELPF---STSSARGHEVPLSTRYTH--ISPRNRAEYVRLALGFR-LHEFDEQVKAVRDG 4741
               |.|:|.|   ..:..:.::|.|....:.  ::..|:.||:.|.:.:| ::...:|:.|..:|
Zfish  1073 ---TELDLRFCIDEDNFGQTYQVDLKPSGSDMVVTNDNKKEYIDLVIQWRFVNRVQKQMNAFLEG 1134

  Fly  4742 MSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYK-GFDPSSALVTWFWEVMEEFTNQER 4805
            .:::||:.|:.:|...||:.::||..|:.:...:....|| |:.|:..::.|||:.:.....::|
Zfish  1135 FTELIPIDLIKIFDENELELLMCGLGDVDVNDWRQHTVYKNGYCPNHPVIQWFWKAVLLMDAEKR 1199

  Fly  4806 SLFLRFVWGRTRLPRT-IADFRGRD----FVLQVLEKNPPDHFLPESYTCFFLLKMPRYSCKAVL 4865
            ...|:||.|.:|:|.. .|:..|.:    |.::  :...||. ||.::|||..|.:|.|.....|
Zfish  1200 IRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIE--QWGTPDK-LPRAHTCFNRLDLPMYETFEDL 1261

  Fly  4866 LEKLKYAI 4873
            .|||..|:
Zfish  1262 REKLLMAV 1269

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 9/35 (26%)
RCC1 4154..4203 CDD:278826 18/61 (30%)
RCC1 4206..4257 CDD:278826 11/53 (21%)
RCC1 4260..4309 CDD:278826 7/48 (15%)
RCC1 4312..4360 CDD:278826 6/59 (10%)
RCC1 4364..4413 CDD:278826 7/48 (15%)
HECTc 4509..4880 CDD:238033 97/388 (25%)
HECTc 4553..4878 CDD:214523 89/344 (26%)
nedd4lXP_021324687.1 C2 <374..430 CDD:326325 12/78 (15%)
WW 473..499 CDD:306827 7/32 (22%)
WW 669..698 CDD:306827 7/28 (25%)
WW 798..829 CDD:197736 9/83 (11%)
WW 856..885 CDD:238122 6/28 (21%)
HECTc 946..1275 CDD:214523 90/350 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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