DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and herc2

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	XP_021332870.1	Gene:	herc2 / 558479	ZFINID:	ZDB-GENE-070718-6	Length:	4831	Species:	Danio rerio

Alignment Length:	5214	Identity:	2241/5214 - (42%)
Similarity:	2990/5214 - (57%)	Gaps:	765/5214 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PSHSPDLYLRPLPFLDAKWLRADLIASLRNAADG-AVLWNHLIQDCELVSSPTAPLLNARGQLSY 128
            ||.|.:..||   |.| |||:.||..:..:  :| :.:||.:::|.|:|               :
Zfish     4 PSFSLNAQLR---FHD-KWLKIDLQRAFSH--EGLSEMWNEMVKDEEIV---------------F 47

  Fly   129 LGDDGKHYCGAQQLKCSCCQPEYCGPLSACNCDGCRPLDSDT--AIKKLTTQAAAQQAAHLSQAT 191
            ..::..|             ||        :|..|.....||  ..||...:|||..|:....:
Zfish    48 DREESAH-------------PE--------DCADCTQKKDDTNDKEKKEEEEAAATAASSFHHS- 90

  Fly   192 DMVLSGWLWSQPPSQQARLDCQRSMISELQELALRAAGNCLSAQHLRQQLFIYERYFVALKRERE 256
              ::..|.|.:.|......||..:::.:.|:|:.:.|.:.|||..|.|:|.|.|||.::|.....
Zfish    91 --IIEMWDWGRQPETSELRDCLMALVDDQQKLSSQTAKSTLSALRLSQRLVILERYLISLTHSMM 153

  Fly   257 RER-----KSTTSAQAVASVTTANTTIAATTANAAVESQPAEQQAEHGALGLARVATHAALNFSF 316
            .|:     ||..|...                 :||:::.| :....|..|||||.:.|||:|:|
Zfish   154 EEKYKVRWKSPPSPPL-----------------SAVDNKSA-RPVSKGVEGLARVGSRAALSFAF 200

  Fly   317 AFLRRAWRSGEDTEMCSELLSEALASLQELPEATLFEAAVVSSLWLEVMERSIKFLRLV---ALG 378
            ||||||||||:|.::|||||.|:|.:|:.|||||||:...||.:||||:||:.|||..:   |.|
Zfish   201 AFLRRAWRSGDDADLCSELLQESLDALRALPEATLFDEGTVSPVWLEVVERATKFLSDIHGSASG 265

  Fly   379 DPMGNRCTAPLNDRHTALCLLLELGVQKGTLAATLECVVLLLLLWEKDRAGNDNRDMPRKTGAPL 443
            ....|   .||.|:|.||.:||||.||:|||:..|..|:|||.||:......||....:.|.|||
Zfish   266 KAPSN---IPLQDQHLALAILLELAVQRGTLSQLLSAVLLLLRLWDSGTREMDNERSTQGTSAPL 327

  Fly   444 QRILLRYQKIGATAKGGGIAGGEPAP-----VASA----TETFLRFLSLPKSSAAIVDLRRAAVV 499
            ..:|.|:|.|.::.:       ||.|     :.||    .|:|||:|:||:.:...:|||:.|||
Zfish   328 LPLLQRFQNIHSSKE-------EPVPEEEIEILSAPLSPNESFLRYLTLPQDNDLAIDLRQTAVV 385

  Fly   500 IISHLDRMVQPLMPRCLLRGGQATAASSSSAPQQRIYALGWPSLSKDQQGFSAEPTLSWSGESAG 564
            |::||||:..|..|      .|.::.:|:....|.:  :||             ..|.|...:..
Zfish   386 IMAHLDRLAAPCSP------PQCSSPTSNKGTLQEV--IGW-------------GLLGWKPYANV 429

  Fly   565 VPTLSCR----FQIKQVACCETQMLILSQEGKLYTWRLAKPEAEPLPMEEVAHDVFISIAGHCEG 625
            ...:.|:    ..:.|:.|.|...|||:..|.:||.........|:.:..:.....:.:|.|.:|
Zfish   430 NGPIQCKALSNLGVTQIVCSEKGFLILTITGAVYTQNYKSTTLAPMLVHALTSRKIMKLAAHPDG 494

  Fly   626 RHFLAIDSNHNAYSWGTGEDHRLGHGDTHARAVPTKIAALEQHCV--QSVY--CGCSYSAAITCG 686
            :|:||:..|...:|||.|:..|||||||.....||.|:......|  |.|:  ||.:||||||..
Zfish   495 QHYLALSVNGEVFSWGCGDGGRLGHGDTTYLEEPTMISVFSGRPVGKQVVHIACGSTYSAAITAD 559

  Fly   687 GNLLTWGRGTYARLGHGNSDDRSLPTLVVALSDHMVVDVALGSGDAHSLALTSEGLVFAWGDGDY 751
            |.|.|||||.|.|||||:|:|::.|.||.||....|:|||.|||||.:||:|..|.|::||||||
Zfish   560 GELHTWGRGNYGRLGHGSSEDQTTPMLVTALKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDY 624

  Fly   752 GKLGNGNCNGSLQPILVESLP--RVQRVFAGSQFSVALSSEGQLYTWGKA--TCLGHQLVERSVQ 812
            ||||.|..:|...|.|||.|.  .:.:|..||||||||:.:||:|||||.  ..|||...|.
Zfish   625 GKLGRGGSDGCKTPKLVEKLQDLDIVKVCCGSQFSVALTKDGQVYTWGKGDNQRLGHGTDEH--- 686

  Fly   813 GCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFGWGRNDSQQICPASVSSE------PLLRT 871
             ...|:|:.|||.||:||:||...|||||:..|||..||.||..|......|::      |.|.:
Zfish   687 -VRYPKLLDSLQGKRVVDIAVGSTHCLALTEEGEVHSWGSNDKLQHFDTLFSNKKQPKALPGLNS 750

  Fly   872 PILVSLPTFPASGIACTSAQSLVWTQSSHQGVPRRAPFVVDLGEPTFRLLDQLL-----GMCSSQ 931
            ..:|        ||:|...||..|:..|...|..|.|||||:...||..||.||     ||..|.
Zfish   751 KHIV--------GISCGPGQSFSWSSCSEWSVGLRVPFVVDVCTMTFDQLDLLLRQVSEGMDGSS 807

  Fly   932 DNRQTPNQESECIAVACLNLFRLQLLALIANGVEPRQVGLASGSRLLCSLKTRILGLAGGSQVLR 996
            |  ..|.||.||:.||.|||.||||.|.|:|.|:|.::||..||.||.:||..::.||....||.
Zfish   808 D--WPPPQEKECMVVAALNLLRLQLHAAISNQVDPEELGLGLGSVLLNNLKQTVVTLASNGGVLN 870

  Fly   997 TIQVAAQQALQDGWSVLLPTAAERAQTLTSLLP---SEPGQASSAGHRFMTDLLVSSLMAEGGLE 1058
            |:|.|||..||.|||||||||.|||:.|:||||   |....:.|.|.|||.|||||||||:||||
Zfish   871 TVQAAAQTVLQSGWSVLLPTAEERARALSSLLPNAASANEMSVSPGRRFMIDLLVSSLMADGGLE 935

  Fly  1059 SALQHAIRLE---------------------SSSCSADC---------GDGVH-------LPLLQ 1086
            |||..||..|                     |:|....|         ..|::       |||:|
Zfish   936 SALNAAITAEIQDIEAKKEAQKEKEIDEQEASASSLHRCRTTLDKDLINTGIYESANKQSLPLVQ 1000

  Fly  1087 LITRLLSNNAALSQTRLSPT---LGKQQEKEEEEREQQHQEPSTSPSLSLLHRFQRLL------- 1141
            |:.:||.|.|:.:..||...   :...|:.|:..:|:       |.||.||.||||||
Zfish  1001 LVQQLLRNIASQTIARLKDVARRISNCQDTEQVSKER-------SASLDLLLRFQRLLVCKLYVG 1058

  Fly  1142 -----------LSHIHQAQPEEETTGAEALLLQYMHALIPACVATLQKAHELALQCREPGENSFG 1195
                       |||       .|..|..:||.:||..|.......|..|..:||       ||.
Zfish  1059 VNGTVGVGGYTLSH-------SEILGVGSLLKKYMALLCTHIGDILPVATSIAL-------NSH- 1108

  Fly  1196 QMVGHLGRVLQADISDALLNELLVGL-LLLKRDRPQCLGGLRWARLFLPLLRV----LDRLNRAL 1255
            :....:.|||:.|::..||.||:|.: |||..|     .||......:|||..    |||.|...
Zfish  1109 RHFAEVARVLEGDLTGVLLPELIVSIVLLLTHD-----AGLMQETGSIPLLAALLEHLDRFNYLA 1168

  Fly  1256 GEGELRDGDDMGWPGIICRGGPKGGPPPA-DPETHYVRRADMENLLLDGSRCIILAGYVCDLSGY 1319
            ...|..|.:|:.|||::  |....||... :.|...:|:||:||...||....::.|.|.|:..:
Zfish  1169 PGTERDDNEDLAWPGLM--GFFFNGPSSKNNEEVSLIRKADLENHNKDGGFWTVIEGKVYDIKDF 1231

  Fly  1320 NCESETLRSVLDSGLGKD----LTAEMSSQVHRTAMEHILEHHKLGKYMVQASTEEKSSAPGPSR 1380
            ..::.|..|:|....|:|    |.|.:..:..|.:|:...    :|:||  ...:|..:.|..|.
Zfish  1232 QAQTLTGNSILAQFAGEDPVVALEAALQFEDTRESMQAFC----VGQYM--EPNQEMVTTPDLSS 1290

  Fly  1381 LTH--FSSECALAQLLGLVANLMCSGPALQPAELQCRQLDKSSLLSGGLQLLQPSNPFDEEKGEA 1443
            |:.  ..:|..|..||||.|:.:.....|...||:|.:..:||:..||||..|....::|||.|
Zfish  1291 LSSPLIDAERNLGLLLGLHASYLAMSTPLSRIELECAKWLQSSIFFGGLQTSQIHYNYNEEKDE- 1354

  Fly  1444 RSSHSCHSTAGNTPTELPPPLPMQQQLAPGRGKSQLQLR-------ADAFISGLAEARVSEPPVA 1501
              .| |.|....||                 .|::|..|       |..|:..:|:....:..|.
Zfish  1355 --DH-CSSPGTTTP-----------------DKAKLYCRRITLSDHAQPFLQAIADNTTQDHTVK 1399

  Fly  1502 AWLALTERYCKAHNLMWHQEFATEHPVQELERLLSAVLIRHQYLGGLVLNALE---------TEV 1557
            .:|...||.||.::|:....|..||||:|:.|||...|::||.||.:.|:.::         .:.
Zfish  1400 DFLCQIERCCKQYHLITPITFPPEHPVEEVGRLLLCCLLKHQDLGHVALSLVDQCALGMDQGKQR 1464

  Fly  1558 PPPRQLGEIIRLVHQAKWSVVRTRQQLNRSYKEVCAPILERLRFLLYEVRPAISPQQRGLRRLPI 1622
            ..|:.:.::.|:|:|||.|:::|.|:..|||||||||::||||||..|:|||:|.....:.:|.:
Zfish  1465 SLPKSVIDVCRMVYQAKCSLIKTHQEQGRSYKEVCAPVIERLRFLFNELRPAVSNDLSIVSKLKL 1529

  Fly  1623 LQRPPRFKMLVRRLLQELRSSRQPAKPE--DLLNASIQQEQEKKPQSMPKQELE---------EQ 1676
            |...||:|.:.::|:::.|..|.|.|.|  ||....::...|:.|..:....::         :|
Zfish  1530 LSSQPRWKRITQKLIRDRRKKRVPKKSESADLEECKMEGTNEEPPAPLSPAPVDKKQTTVKSAKQ 1594

  Fly  1677 EEEETLLRRLNERQIHG------EGEL-DPALMQDIVDFAL-QDSCDVETARRAMYCQMQRYQLR 1733
            ::.:.||..:...|.:.      :|.. ..:||..||:|:| ::..|||..|:.:..|::|.::|
Zfish  1595 DKWQPLLNTIGSVQKYRWLRHSVQGSFSQSSLMSTIVEFSLKEEPLDVEKIRKCLLKQLERAEVR 1659

  Fly  1734 LAGLQIVQQLLELHGLLDAAQYSLLNGFLGLHLKSTSSGGGSTGSGSSLHVLGQLNMISAYQKAR 1798
            |.|:..:.:|...:.||.:.||::|.|:..:..:.|:.|      ......|..:::|..:.:..
Zfish  1660 LEGIDTMLKLASKNFLLPSVQYAMLCGWQRVIPEGTNIG------EPLADCLKDVDLIPPFNRML 1718

  Fly  1799 LLLAQSRVLDWAVRELRRLV---------------------NQEQQGHARGKDSTNLGTYVLLKR 1842
            |.:...::..|:::.:|.::                     |:...|       .:|||
Zfish  1719 LEVTFGKLYAWSIQNVRNILLEASVKFKELGVQPVPLQTITNENPAG-------PSLGT------ 1770

  Fly  1843 LPRARFLLSVFGLLAKELGPNELGFLINSGLLGTVLGLLAQTG-----GEGATGGQVHGELSILY 1902
            :|:|||||::..:|..:.|.|.|..|:|||:|.....:|...|     .|.......||..:.:.
Zfish  1771 IPQARFLLAMLHMLTLKHGANSLSLLLNSGILALTQSVLRLIGPSCDSSEEELTSVAHGGSATVL 1835

  Fly  1903 EDSVLKQKSSKAQLSGPDLAKLMKIGTRIVRGADWKWGDQDGNPPGEGRIISEVGEDGWVRVEWY 1967
            |:|..:...:....|||:||.:|||.||::||.|||||||||..||.||:|.|:|||||:||:|.
Zfish  1836 EESRKETAPTPLPASGPELAAMMKISTRVMRGPDWKWGDQDGPSPGLGRVIGELGEDGWIRVQWD 1900

  Fly  1968 TGATNSYRMGKEGQYDLQLADSALNVASPTEPEREDVSGSEASPTSD----------SHPSKLLR 2022
            ||:||||||||||:|||:||:.    ...|:|..||      |.|.|          :||:.::.
Zfish  1901 TGSTNSYRMGKEGKYDLKLAEP----PPATQPATED------SDTEDDTEGEVMEKCAHPTAIML 1955

  Fly  2023 HCAAKLLQILAVGTGLHGAQLDKDALRGMTSMFRTIIYPKPSMSN-----ISYAL-------GWL 2075
            .....||:.|::.:|:|...:..||:..:..:.|.::   .|.:|     .|:.|       .|.
Zfish  1956 TSTVNLLKTLSLSSGIHAEVMQVDAVSTLCGLLRILV---ESGANDKTGCSSHKLVSREQHRSWC 2017

  Fly  2076 NLGFIRAISGDCPRLCLELSTPGWLSHYLSLLEQPAGNEA----GVYRQLHCLRLLQLILAQWGA 2136
            .|||||:|: ..|::|..||:..|::..:.::|   |:::    .:.||:..|||||.:|..|..
Zfish  2018 TLGFIRSIA-LMPQMCSTLSSSAWINLLIRIVE---GHQSFTAITLQRQILALRLLQAVLPSWDK 2078

  Fly  2137 EEEPR-MPALVHQLFATLGRIALHCPGDASLLPTAEGKAR-------VLLTASHSGSVAEELVAL 2193
            .|..: |..||.:||..||.:...|..|..||  .||..|       ..|||:||.::|||:|.:
Zfish  2079 TERSQDMKFLVEKLFGFLGSLLSTCSSDLPLL--REGSMRRRKSRPQASLTATHSSTLAEEIVTV 2141

  Fly  2194 LRRLHTLPSWNPVINSFLAQKLCVAAELLAEQSHSTAL------DSEQVFV---LGVLGAMGGHD 2249
            ||.||:|..||.:||.::..:|....:::|.:....||      ::|...|   :.||..:||.|
Zfish  2142 LRTLHSLSQWNALINEYINSQLSGIGDVMAGRHTEVALLEDYLPNAEAAAVGSLMAVLAVIGGID 2206

  Fly  2250 LRPRVGLHCFHEG-SHMVIASFTPKGRCLLAPGGVGSGVGF-----VKVQLPAVMPHLDHTVFSL 2308
            .|.|:|....||. ....:...|||||..         |.|     .||.|.:.:..|....||:
Zfish  2207 GRLRLGGRVVHEEYGEGTVTRITPKGRIT---------VQFHEMRNCKVCLLSQLKPLHMIPFSV 2262

  Fly  2309 SRLPMNEMLLNAWTVL--LYGPAPELRELPSS------ADGRLDLALLRAQQLQMAVLHTNGVLY 2365
            ..||..|.:|..|..|  |.|...|.:.:..|      || ::|:.|||.|||::.:|.....|.
Zfish  2263 QNLPFAEPMLMVWAQLVNLAGSKLEKQRMKKSLSRGLTAD-QVDVHLLRCQQLRLYILKAARALL 2326

  Fly  2366 RHQVALRRILKQRAPGSIYASPDE------PDRSDAESQQPGEQDQQLSSGSGQEPQLLIQCILL 2424
            .||..||:||.|.|...:..:|.|      ||..|...:.|            |.|.:|:|.:|.
Zfish  2327 SHQDKLRQILSQAAVVDVSPNPTEDQCASSPDVGDLSPEGP------------QPPLILLQQLLS 2379

  Fly  2425 RATQASPVKACYSYMDLATAALNCIQSLATQAHQELSEGGGVPPNGRALSSPPQPTMVHGVPVYN 2489
            .:||.||:||.:...:|..|||...|.||.::....|      |.....||....|        .
Zfish  2380 ASTQPSPIKAIFHRQELEAAALAVCQYLAVESTHPSS------PLFEDSSSSEATT--------P 2430

  Fly  2490 VARKEQKPSEQVEQKSKWPAAATDAQLIGQIMEMGFTRRTVELALKQLS--LQAEIMPTPEQIVQ 2552
            |..:..:|.:|.:.|:   :....|.::.|:|||||.|:.:|.|||.||  ..|..:|..|.:|.
Zfish  2431 VTVQHMRPPKQKKHKT---SPVPPAPIVLQLMEMGFQRKNIEFALKSLSGTTGASGVPGVEALVG 2492

  Fly  2553 WILEHPDVCANTIEEDTLPLASSASSHDPEADSDNECPSSNSTTSSSTSSDTV-----EGQPMAV 2612
            |:|:||||....:                   ||.|      |.|...|.:.|     |.:|
Zfish  2493 WLLDHPDVLITDL-------------------SDAE------TVSDEYSDEEVLEELEEPEP--- 2529

  Fly  2613 SGPAPP-------VKFESRKDFQTADLYALYVRGLVRPGMTVRCCRDFEEIKQGDMGTVLIVDTE 2670
            :.|.||       ..|:.|.|||:.|.||:|||..::.||.|||||.:||:.:||:|.|:.:|.:
Zfish  2530 AFPVPPGVVVTESQTFKKRSDFQSNDDYAVYVRENIQVGMMVRCCRTYEEVYEGDVGKVIKLDRD 2594

  Fly  2671 GLHDLNVQVDWRNHGSTYWVCFVHIELVEAAQTHHQPRPPPIAVGARVRLR----TSSLRYGMLC 2731
            ||||||||.||:..|.||||.::|.||:....   |..|..|.:|.:||::    |...::|
Zfish  2595 GLHDLNVQCDWQQKGGTYWVRYIHTELLGFPP---QSSPSHIKIGDKVRVKPSVTTPKYKWG--- 2653

  Fly  2732 PLRLGRSQGSSAIGVVS--SVRSKQLTVDFPDQPAWQGHINEVELVASQPTSATLPSLGDSCSQM 2794
                  |....::|||.  |...|.:.||||.|..|.|.::|:|||.|.......    |.|...
Zfish  2654 ------SVTHRSVGVVKAFSANGKDVIVDFPQQSHWTGLLSEMELVPSVHPGVRC----DGCQMF 2708

  Fly  2795 P-------------------------------------PSD----------------------LI 2800
            |                                     |..                      ||
Zfish  2709 PINGPRFKCRSCDDFDFCESCFKTRKHNPRHSFGRINEPGQSPTFSGRSGKQLKRHHSSQRGMLI 2773

  Fly  2801 EDWSRCIRSLTVSSNEAAAKHLLNGSNQPWQSCSSGPCRHWIRLELHDRILVHSLTLKVSPEDHS 2865
            ::|||.:::|:|||:...|..|::...|.||| |....:|||||||...:|||.|.:.|.|.|.|
Zfish  2774 DEWSRVVKNLSVSSSVNQASRLIDCGEQCWQS-SGSQGKHWIRLELFPDMLVHKLKMIVDPADSS 2837

  Fly  2866 HMPSLLEIRVGDCVDSLKEYTWIPVPAGASRVLLMQQVPTYYPWVEVVVKQCQNNGIQCKIHGIK 2930
            :||||:.:..|..:::|.|...|.:....:.|.|:.....|:.::||.:|||:::||.|||||:.
Zfish  2838 YMPSLVVVSGGTSLNNLIELKTININPTDTVVSLLNDCTEYHRYIEVAIKQCRSSGIDCKIHGLS 2902

  Fly  2931 FVGRRQQPDLQHILANAQFLASEYSAGVGPGSTAGA-GAVSTSHEEAAAAPEQDLPCTVMVWGLN 2994
            .|||.:..|  ..||...||||:........:..|: .....|..|:||.    :...|.|||||
Zfish  2903 AVGRVRAED--EDLATVPFLASDNEEEEDEKTATGSMSRKRLSGLESAAT----IRTKVFVWGLN 2961

  Fly  2995 DKEQLGGLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNGRLGLGVTH-N 3058
            ||:|||||||||:|||:||:|:|.|..:.:||||||||.|:.:||||||||.||||||||::. .
Zfish  2962 DKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTAEGKVYACGEATNGRLGLGLSSGT 3026

  Fly  3059 VPLPHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALR 3123
            :|:|.|:..|..||||||||||||:||:|||:||||||||||:||||||.:|...|||||:|||:
Zfish  3027 IPIPRQISALSNYVVKKVAVHSGGRHAMALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALK 3091

  Fly  3124 AKKIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQLKPKLVTALAGRRVVQVACGSRD 3188
            .|:|||:||||||||||:|.||||:||||||||||||||||||:||||..|.|.|||||||||||
Zfish  3092 TKRIRDIACGSSHSAAITSSGELYSWGLGEYGRLGHGDNTTQLRPKLVKVLLGHRVVQVACGSRD 3156

  Fly  3189 AQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERLSGIGVVQIECGAQFSLALTRAGEVW 3253
            |||||||::|.|||||||||||||||||||.:.|..||||:|.||.|||||||||||||::|.||
Zfish  3157 AQTLALTDEGMVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVW 3221

  Fly  3254 TWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSG 3318
            |||||||:|||||.|.||||||.:.||||::::|||||||||||||:.|||:|||||||||||:|
Zfish  3222 TWGKGDYFRLGHGTDVHVRKPQMVEGLRGKKIVHVAVGALHCLAVTETGQVFAWGDNDHGQQGNG 3286

  Fly  3319 NTFVNKKPALVIGLDAVFVNRVACGSSHSIAWGLPNASSDEEKRGPVPFSSTRDPLGGSSLGIYE 3383
            .|.||:||.||.||:...:.|||||||||:||...:.::..... ||.|.:.||.||.|.||:..
Zfish  3287 TTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVTTPSVHE-PVLFQTARDSLGASYLGVPS 3350

  Fly  3384 AETMQTLKQE------AKPLNQSSLSE-SLALETPAARQAALGHVLRAMSILQARQLIVAALTSH 3441
            ......|..:      .|| |:.||:: .|:|:...|:|.||.|||.::.|:.||..:|.||...
Zfish  3351 DSDPSLLSNKLNGVNNVKP-NRPSLAKILLSLDGNLAKQQALSHVLSSLQIMYARDAVVGALMPS 3414

  Fly  3442 SKVNFKERGAVGGEEDHLIGGPIMGAPLQLAETIAQGGGEA-PADATDAGLQEHSPEAAVDALTG 3505
            ..:..:...:          .|:..:....|.:..:..|.| |:::.    :..||...:|:..|
Zfish  3415 CMMPLECPSS----------SPVPPSDCSSASSPCEAEGPALPSESE----ERVSPHPWMDSKRG 3465

  Fly  3506 GMSGGANTLPPLSAGPLSAFQSLTGSLSMSGSLSSSALPQHKHSRMSASAMSVMAATMTQQEEML 3570
            .::...:...|.||...|     |.|.|....:..:..|         .|.|::|.|||:.:|..
Zfish  3466 EVTTSEDATTPSSAVTPS-----TASASSRPFIPVTDDP---------GAASIIAETMTKTKEDS 3516

  Fly  3571 SHISHCHG-----LDDFGGLLGEPEAKSLVELLKLAVCGRCGPPSTSQTIADTLISLGAGTPAVA 3630
            .:.|...|     ||:|..||...:.:.:|:||||||..|.|... .:.::..|..:|...|.||
Zfish  3517 ENQSKAVGPEPQYLDEFTSLLIPDDTRVMVDLLKLAVSLRSGDKG-KEVLSAVLSGMGTACPQVA 3580

  Fly  3631 AMLLETCITELEDLCTSRHC-LGKL-PKPVMQESSHPYVDNVNVTGVVRIPGAEMLRLEFDSQCS 3693
            .||||.|:|||||:.|.  | .|:| .:||:.||||||:|:.:.:|.|:|||||.||:|||.|||
Zfish  3581 DMLLELCVTELEDVATD--CQSGRLSSQPVVVESSHPYIDDTSTSGTVKIPGAEGLRVEFDRQCS 3643

  Fly  3694 TEKRNDPLVIMDGTGRVLAMRSGREFAHWAPEIRVLGDELRWKFSSDSSVNGWGWRFWVHAIMPA 3758
            ||:|:|||.||||..|::::|||||::.|:.|:|:.||||:|||:||.|||||||||.|:.||||
Zfish  3644 TERRHDPLTIMDGANRIVSVRSGREWSDWSSELRIPGDELKWKFTSDGSVNGWGWRFTVYPIMPA 3708

  Fly  3759 ATLGESGSDRAVLSQPSMALVMSLLDSRL-APRQPSVLLRLASALAACSQLGALTTAQRIWSLRK 3822
            |...:..|||.:||.|||.||..|||.|| .....|::.|||::||||:||.||....|:|:|::
Zfish  3709 AGPKDLLSDRCILSCPSMDLVTCLLDFRLNFASNRSIVPRLAASLAACAQLSALAAGHRMWALQR 3773

  Fly  3823 LHAVLLLE------------------QAPRPQDPSLSTLLQPLIPELLRQYEYEEPQVRGGIHLM 3869
            |..:|..|                  ::......:|:.|::.|...|.||||||||.||||..|:
Zfish  3774 LRKLLTTEYGQSININRLLGDTEGEARSMSFTGSALAALVKGLPEALQRQYEYEEPIVRGGKQLL 3838

  Fly  3870 HSDYFKTLAALACDMQLDAALPATSSSSSSSAAPGAISSTGDVHKWAWFKRYCIAVRVAQSLIRR 3934
            ||.:||.|.|||||::|| .||..:                :.||||||:|||.|.||:.:|.:|
Zfish  3839 HSPFFKVLVALACDLELD-TLPCCA----------------ETHKWAWFRRYCTASRVSVALDKR 3886

  Fly  3935 TELPRAFCLE-VRKKFAEMLPSSSSNSNANPGCQSPGASMLNSTTSLSSSTVSNVSPPPGITGEQ 3998
            :.|||.|..| |.||..|::   :.:.|.|
Zfish  3887 SPLPRPFLDEVVAKKIRELM---ADHENMN----------------------------------- 3913

  Fly  3999 PDLHCHAHQLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLG 4063
                           .|||.|.||:...|.||:||:|||||||.||.||:.||||||||||||||
Zfish  3914 ---------------TLHESHDLFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLG 3963

  Fly  4064 GLEGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTPDGKLFATGYGSGGRLGVGGSDSWAIPTLL 4128
            |:||:::|.|||.|||:.||||||.||||:|||||.||||:|||||:|||||:||::|.:.||||
Zfish  3964 GIEGAKVKVPTPTEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLL 4028

  Fly  4129 GSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEGEDGKLGHGNRMSYDRPKLVEHLNGMSVADI 4193
            .|:||||::||||||||||||||::|||:|:|||.||||||||||...|||:::|.|.|:.|.||
Zfish  4029 ESIQHVFIRKVAVNSGGKHCLALSSEGELYSWGEAEDGKLGHGNRSPCDRPRVIESLRGVEVVDI 4093

  Fly  4194 ACGSAHSAAITASGHVLTWGKGRYGRLGHGDSEDQLRPKLVEALLGYRAIDIACGSGDAQTLCIT 4258
            |.|.||||.|||||.:.|||||||||||||||||||:|||||||.|:|.||:|||||||||||:|
Zfish  4094 AAGGAHSACITASGELYTWGKGRYGRLGHGDSEDQLKPKLVEALQGHRVIDVACGSGDAQTLCLT 4158

  Fly  4259 DDDNVWSWGDGDYGKLGRGGSDGCKLPYKIESLAGLGVVKVECGSQFSVALTKSGAVYTWGKGDF 4323
            |||.|||||||||||||||||||||:|.||:||.||||||||||||||||||||||||||||||:
Zfish  4159 DDDMVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDY 4223

  Fly  4324 HRLGHGSVDHVRRPKKVAALQGKKIISIATGSLHCVACSDSGEVYTWGDNDEGQLGDGTVTAIQR 4388
            |||||||.||||||::|..|||||:|:|||||||||.|::.||||||||||||||||||..||||
Zfish  4224 HRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQR 4288

  Fly  4389 PRLVAALQGKHIVKVTCGSAHTLALSTSQLSERLRPLPNPPLEYDLVRDLAPEALHARLILLHHF 4453
            ||||||||||.|.:|.||||||||.|||:.:...:.....|:||:.::::|...|..||:||||.
Zfish  4289 PRLVAALQGKKINRVACGSAHTLAWSTSKPTNAGKLPAQVPMEYNHLQEIAIIGLRNRLLLLHHI 4353

  Fly  4454 SELVCPCLAMLPISGDL-------SLG--ALKDVLVYNIKEAAFRKVIQTTMVRDKQHGPVIELN 4509
            |||.|||:.|..:.|.|       |:|  .|:.:|:...||||||||:|.|||||:|||||:|||
Zfish  4354 SELFCPCIPMFDLEGRLGETGHGVSVGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELN 4418

  Fly  4510 RIQVKRSRNRCNGLAGIDGMKSVFGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSES 4574
            ||||||||:: .||||.||.|||||||..|:...:.::|.|||||||||||||||||||||||||
Zfish  4419 RIQVKRSRSK-GGLAGPDGTKSVFGQMCAKMSSFSPDSLLLPHRVWKVKFVGESVDDCGGGYSES 4482

  Fly  4575 IAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPL 4639
            |||||:|||||..||||.|||||.|:|||||||||:|...|.|.::||||||||:|||:||||||
Zfish  4483 IAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPAAKSPLHISMFRFLGVLLGIAIRTGSPL 4547

  Fly  4640 SINLAEPVWRQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFSTSSARGHEVPL 4704
            |:.||||||:||.|..|...||:|||:|::.||:.||:.:...:.|.|:.|||:..||.|.||.|
Zfish  4548 SLYLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEASAEEFEAMPLPFTVPSACGQEVQL 4612

  Fly  4705 STRYTHISPRNRAEYVRLALGFRLHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDI 4769
            |::::|||..||:||||||:.:|||||||||.|||:||::|:||||||||:..||:.||||||||
Zfish  4613 SSKHSHISLENRSEYVRLAINYRLHEFDEQVSAVREGMARVVPVPLLSLFTGYELETMVCGSPDI 4677

  Fly  4770 PLGLLKSVATYKGFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRTIADFRGRDFVLQV 4834
            ||.||||||||||.:|::.|:.|||||||.|:|.||||||||||||||||||||||||||||:||
Zfish  4678 PLHLLKSVATYKGVEPTAPLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVVQV 4742

  Fly  4835 LEK-NPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSIDTDEYARVAM-GEPT--EA 4895
            |:| ||||||||||||||||||:||||||.||.||||||||||||||||:|||:|: |||.  ::
Zfish  4743 LDKYNPPDHFLPESYTCFFLLKLPRYSCKLVLEEKLKYAIHFCKSIDTDDYARIALSGEPAADDS 4807

  Fly  4896 TGSEDNSDLESVAS 4909
            :...||.|.:|.||
Zfish  4808 SDDSDNEDADSFAS 4821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826	22/48 (46%)
		RCC1	687..737	CDD:278826	30/49 (61%)
		RCC1	740..787	CDD:278826	26/48 (54%)
		RCC1	790..841	CDD:278826	25/52 (48%)
		RCC1_2	828..857	CDD:290274	16/28 (57%)
		Cyt-b5	1290..1363	CDD:278597	20/76 (26%)
		MIB_HERC2	1928..1987	CDD:284184	42/58 (72%)
		UBA_HERC2	2515..2559	CDD:270585	20/45 (44%)
		Cul7	2624..2699	CDD:288381	42/74 (57%)
		APC10-HERC2	2762..2932	CDD:176485	66/228 (29%)
		RCC1	3037..3088	CDD:278826	34/51 (67%)
		RCC1	3091..3140	CDD:278826	37/48 (77%)
		RCC1	3144..3194	CDD:278826	43/49 (88%)
		RCC1	3197..3246	CDD:278826	38/48 (79%)
		RCC1	3250..3298	CDD:278826	36/47 (77%)
		RCC1	3302..3350	CDD:278826	33/47 (70%)
		RCC1_2	4136..4166	CDD:290274	22/29 (76%)
		RCC1	4154..4203	CDD:278826	32/48 (67%)
		RCC1	4206..4257	CDD:278826	42/50 (84%)
		RCC1	4260..4309	CDD:278826	43/48 (90%)
		RCC1	4312..4360	CDD:278826	39/47 (83%)
		RCC1	4364..4413	CDD:278826	41/48 (85%)
		HECTc	4509..4880	CDD:238033	268/371 (72%)
		HECTc	4553..4878	CDD:214523	239/325 (74%)
herc2	XP_021332870.1	RCC1	<483..772	CDD:332518	138/300 (46%)
		Cyt-b5	1204..1276	CDD:306642	20/75 (27%)
		MIB_HERC2	1862..1920	CDD:310955	42/57 (74%)
		UBA_HERC2	2453..2499	CDD:270585	20/45 (44%)
		Cul7	2548..2625	CDD:314424	42/76 (55%)
		ZZ_HERC2	2700..2744	CDD:239084	3/47 (6%)
		APC10-HERC2	2759..2902	CDD:176485	54/143 (38%)
		RCC1	2946..3316	CDD:332518	272/373 (73%)
		RCC1	4020..4325	CDD:332518	237/304 (78%)
		HECTc	4418..4789	CDD:238033	268/371 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595271
Domainoid	1	1.000	474	1.000	Domainoid score	I418
eggNOG	1	0.900	-	-		E1_COG5184
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3430
Inparanoid	1	1.050	3602	1.000	Inparanoid score	I9
OMA	1	1.010	-	-		QHG50139
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	1	1.000	-	-		FOG0007465
OrthoInspector	1	1.000	-	-		oto39909
orthoMCL	1	0.900	-	-		OOG6_102650
Panther	1	1.100	-	-	LDO	PTHR22870
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4599
SonicParanoid	1	1.000	-	-		X6340
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800