DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and WWC3

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_056506.2	Gene:	WWC3 / 55841	HGNCID:	29237	Length:	1092	Species:	Homo sapiens

Alignment Length:	869	Identity:	184/869 - (21%)
Similarity:	292/869 - (33%)	Gaps:	255/869 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  2124 LRLLQLILAQWGA--------EEEPRMPALVHQLFATLGRIALHCPGDASLLPTAEGKA-RVLLT 2179
            |:.||||:||..:        ||..|:...:.:..||                :|:|.. |:||
Human   281 LQELQLIIAQRRSAGDVARLEEERERLEEELRRARAT----------------SAQGATERILL- 328

  Fly  2180 ASHSGSVAEELVALLRRLHTLPSWNPVINSFLAQKLCVAAELLAEQSHSTALDSEQVFVLGVLGA 2244
                   .|:...||.:|.........:.|.| :.||.:...::..|...:|.|.:..:....|:
Human   329 -------QEKRNCLLMQLEEATRLTSYLQSQL-KSLCASTLTVSSGSSRGSLASSRGSLASSRGS 385

  Fly  2245 MGGHDLRPRVGLHCFH----EGSHMV---IASFTPKGRCLLAPGGVGSG-VGFVKVQLPAVMPHL 2301
            :.........||..:.    |||.::   :..|...||.  ||.....| .||.|.:.....|.
Human   386 LSSVSFTDIYGLPQYEKPDAEGSQLLRFDLIPFDSLGRD--APFSEPPGPSGFHKQRRSLDTPQ- 447

  Fly  2302 DHTVFSLSRLPMNEMLLNAWTVLLYGPAPELRE--LPSSAD---------------GRLDLALLR 2349
                 ||:.|.....|.:     |..|:..|..  ||:|.|               |.||.....
Human   448 -----SLASLSSRSSLSS-----LSPPSSPLDTPFLPASRDSPLAQLADSCEGPGLGALDRLRAH 502

  Fly  2350 AQQL------QMAVLHTNG-----------------------VLYRHQVALRRILKQRAPGSIYA 2385
            |..:      .||.|..:|                       |..|...|.|  |::||......
Human   503 ASAMGDEDLPGMAALQPHGVPGDGEGPHERGPPPASAPVGGTVTLREDSAKR--LERRARRISAC 565

  Fly  2386 SPDEPDRSDA-----------ESQQPGEQDQQLSSGSGQEPQLLI--------QCILLRATQ-AS 2430
            ..|....||:           ::::|...|    :.|..:||:.:        :|:|:...| .:
Human   566 LSDYSLASDSGVFEPLTKRNEDAEEPAYGD----TASNGDPQIHVGLLRDSGSECLLVHVLQLKN 626

  Fly  2431 P------------VKACYSYMDLATAALNCIQSLATQAHQELSEGGGVPPNGRALS--------- 2474
            |            ::.....:|..|....|.::|..|.....:|...:|.:..||:
Human   627 PAGLAVKEDCKVHIRVYLPPLDSGTPNTYCSKALEFQVPLVFNEVFRIPVHSSALTLKSLQLYVC 691

  Fly  2475 --SPPQPTMVHGVPVYNVARKEQKPSEQVEQKSKW----------PAAATDAQLIGQ-------- 2519
              :|.....:.|:...|:|..:...    |.:.:|          |:...:|...|:
Human   692 SVTPQLQEELLGIAQINLADYDSLS----EMQLRWHSVQVFTSSEPSRTREAGCAGESSARDPAH 752

  Fly  2520 -IMEMGFTRR-TVELALKQLSLQAEIMPTPEQIVQWILEHPDVCANTIEEDTLPL------ASSA 2576
             |...|.|.. ||.||.....|||......|:..:  ||:       .||:.|.:      |.:.
Human   753 TISISGKTDAVTVLLARTTAQLQAVERELAEERAK--LEY-------TEEEVLEMERKEEQAEAI 808

  Fly  2577 SSHDPEADS-DNECPSSNSTTSS-------STSSDTVEGQPMAV-SGPAPPVKFESR-----KDF 2627
            |....:||| |:.|  ||.|.:|       ....|::.|.|.|. :||..|.||:..     |:.
Human   809 SERSWQADSVDSGC--SNCTQTSPPYPEPCCMGIDSILGHPFAAQAGPYSPEKFQPSPLKVDKET 871

  Fly  2628 QTADLYALYVRGLV--RPGMTVRCCRDFEEIKQGDMGTVLIVDTEGLHDLNVQVDWRNHGSTYWV 2690
            .|.||:......||  ||.   |..|....::.   ||::...|           :.....:.:|
Human   872 NTEDLFLEEAASLVKERPS---RRARGSPFVRS---GTIVRSQT-----------FSPGARSQYV 919

  Fly  2691 CFVHIELVEAAQTHHQPRPPPIAVGARVRLRTSSLRYGMLCPLRLGRSQGSSAIGVVSSVRSKQL 2755
            |.::....:::..   ||..|.   .|..|...:|||...|         .|::..:.:..|..|
Human   920 CRLYRSDSDSSTL---PRKSPF---VRNTLERRTLRYKQSC---------RSSLAELMARTSLDL 969

  Fly  2756 TVDFPDQPAWQGHINEVELVASQPTSATLPSL---GDSCSQMPP--------SDLIEDWSRCIR- 2808
            .:|.......|..:|| ||.|.:.....|...   |.  :.:||        ..|:.:..|..|
Human   970 ELDLQASRTRQRQLNE-ELCALRELRQRLEDAQLRGQ--TDLPPWVLRDERLRGLLREAERQTRQ 1031

  Fly  2809 -SLTVSSNEAAAKHLLNGSNQPWQ 2831
             .|.....:||.|.|...|.:.:|
Human  1032 TKLDYRHEQAAEKMLKKASKEIYQ 1055

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585	14/53 (26%)
		Cul7	2624..2699	CDD:288381	15/81 (19%)
		APC10-HERC2	2762..2932	CDD:176485	20/83 (24%)
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
WWC3	NP_056506.2	THOC7	<4..119	CDD:283305
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	363..384		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..488		20/78 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..544		4/33 (12%)
		C2_Kibra	602..725	CDD:176062	21/126 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900