DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and LOC556872

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:XP_021334149.1 Gene:LOC556872 / 556872 -ID:- Length:1472 Species:Danio rerio


Alignment Length:1269 Identity:258/1269 - (20%)
Similarity:387/1269 - (30%) Gaps:476/1269 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly  1695 GELDPALMQDIVD--FALQDSCDVETARRAMYCQMQRYQLRLAGLQIVQQLLELHGLLDAAQY-S 1756
            |.:|..|.|.|.:  :.....|   |.|:....::.........::....|.|...||::.:: .
Zfish   111 GSMDSQLQQVIRENLYLRAVPC---TTRQPRDGEISGVDYNFVSVEEFFSLEESGALLESGKFKE 172

  Fly  1757 LLNGFLGLHLKSTSSGGGSTGSGSSLHVLGQLNMISAYQKARLLLAQSRVLDWAVRELRRLVNQE 1821
            ..|||..|.       |...|:...:|: |..:...:||:.|.||...|                
Zfish   173 KKNGFESLE-------GNYYGTPRPVHI-GPDSPPISYQEHRNLLRNFR---------------- 213

  Fly  1822 QQGHARGKDSTNLGTYVLLKRLPRARFLLSVFGLLAKELGPNELGFLINSGLLGTVLGLLAQTGG 1886
                .|.|..:||..                    |.|.|.|...   :|||.|         |.
Zfish   214 ----TRSKSLSNLEK--------------------AGEEGDNSEE---DSGLSG---------GS 242

  Fly  1887 EGATGGQVHGELSILYEDSVLKQKSSKAQLSGPDLAKLMKIGTRIVRGADWKWGDQDGNPPGEGR 1951
            .||:...||              .||.:|             :|.:||.:.. ..::|..|..|.
Zfish   243 AGASSVPVH--------------TSSPSQ-------------SRNLRGGNTS-ALENGLGPRRGA 279

  Fly  1952 IISEVGEDGWVRVEWYTGATNSYRMG-----KEGQYDLQLADSALNVASP------------TEP 1999
            .:.  |.:.|..:  |:.:.|:|...     ....:..:.|.|..||..|            |:.
Zfish   280 RVR--GSENWEMM--YSDSGNAYYKDHHLKPSSSSWLNRRAHSRDNVCMPEYISHSCIWQSLTDL 340

  Fly  2000 EREDVSGSEASPTSDSHPSKLLRHCAAKLLQILAVGTGLH--GAQLDKDALRGMTSMFRTIIYPK 2062
            :.:.|..:|.:    ..||:|........|...|.|.|.:  |....::.|:     ..:|....
Zfish   341 QSQCVQVAEFT----DQPSELRGFSVHTRLVKGARGFGFNIVGGSRRREFLQ-----IYSITPGG 396

  Fly  2063 PSMSNISYALGWLN----LGF--------IRAI-------------------SGDCPRLCLELST 2096
            ||..|.:..|.::|    ||:        ::||                   |..||:    :|.
Zfish   397 PSTLNTADILVYINDTCVLGYSHKDVVEMLKAIPIGHTVDIMVRRGYPMLYNSEGCPK----MSN 457

  Fly  2097 PGWL-----SHYL--SLLEQPAGNEAGVYRQLHCLRLLQLILAQW-----GAEEEPRMPALVHQL 2149
            |...     |.:|  ....||.......|.|||    |......|     |:....|:.|     
Zfish   458 PRLTASQNQSPHLPPPTTTQPQAQAPLPYAQLH----LNHNSPPWADFDRGSSRNLRVRA----- 513

  Fly  2150 FATLGRIALHCPGDASLLPTAEGKARVLLTASHSGSVA--------EELVALLRRLHTLPSWNPV 2206
                .|.:|...|::   |......|.  .:|:.||..        ......:|||.        
Zfish   514 ----SRFSLDANGNS---PPFASPPRP--PSSYQGSNGYGSGFLRPPRTARSIRRLQ-------- 561

  Fly  2207 INSFLAQKLCVAAELLAEQSHSTALDSEQVFVLGVLGAMGGH-------------DLRPRVGLHC 2258
                       :|| ||.||     |||      |:.|:|.|             ...|.:.||.
Zfish   562 -----------SAE-LASQS-----DSE------VVSAIGSHRASFIRNHNNNSLSTPPPLRLHS 603

  Fly  2259 FHEGSHMVIASFTPK-------GRCLLAPGGV----GSGVGFVKVQLPAVMPHLDHTVFSLSRLP 2312
            | :.|...::|.||.       ....|:||.|    |.|..:         .||        |.|
Zfish   604 F-KSSESDLSSSTPPPISRLPLPHTELSPGPVSFSPGGGRRY---------SHL--------RKP 650

  Fly  2313 MNEMLLNAWTVLLYGP-------------APELRELPS---------------SADGRL-DLALL 2348
            .|.||....:|...||             :|. ..:||               :|.|.| .:||.
Zfish   651 QNSMLTPPSSVHSDGPYFTFNGTASASSGSPN-SSIPSPGALSAVIGSGVGGMAAGGELVPVALA 714

  Fly  2349 RAQQ-------------------------------LQM--AVLHTNG-------------VLYRH 2367
            :.::                               ||.  ||:..||             :|..|
Zfish   715 KCERGSNMGFSVTAGGHGGRQTLVKKVWDHRQCNGLQSGDAVVKINGADVQSLSFAQVQRILQEH 779

  Fly  2368 ----QVALRRILKQRAPGSIYASPDE-------PDRSDAESQQPGEQDQQLSSGSGQEPQ-LLIQ 2420
                :|.|   |..|.|.:...||..       |.||.::|:.|......||..|...|. .|::
Zfish   780 TKKGEVIL---LVYRGPSNYSNSPSSVRRLTPPPPRSASDSEVPFTDSMPLSRNSLTPPSPALVR 841

  Fly  2421 CILLRATQASPVKACYSYMDLATAALNCIQSLATQAHQELSEGGGVPPNGRALSSPPQPTMVHGV 2485
            ..|:::|         |::|.....|    :|..:......:||.|...........||..:.| 
Zfish   842 SSLVQST---------SFLDSVPVTL----TLEPRDWMSSEDGGTVLSPRVKTEEKEQPPALRG- 892

  Fly  2486 PVYNVARKEQKP---------SEQVEQ--------------KSKWPAAATDAQLIGQIMEMGFTR 2527
              |.|..| :||         |:.||.              :...|||.:.....|..:|....|
Zfish   893 --YEVELK-RKPGEGFGFVIASQDVENVKAVSLLPHRFVTVRRGSPAARSGQIRPGDRLEAVDGR 954

  Fly  2528 RTVELALKQLSLQAEIMPTPEQIVQWILEHPDVCANTIEEDTLPLASSASSHDPEADSDNECPSS 2592
            ..|.|..::|:          ||::       ...||:....:|.||:.||...:.|.|.:   :
Zfish   955 SVVNLPHRELA----------QILR-------RAGNTLRLTIVPRASAHSSERADYDPDYK---N 999

  Fly  2593 NSTTSSSTSSDTVEGQPMAVSGPAPPVKFESR--KDFQTADLYALYVRGLVRPGMTVRCCRDFEE 2655
            ..|..|....|......:.:........|..|  .::.    ..|||.||:..|...|.    .:
Zfish  1000 RKTHKSKPKQDATRYYSVELERGPTGFGFSLRGGSEYN----MGLYVLGLMEGGPASRS----HK 1056

  Fly  2656 IKQGDMGTVLIVDTEG------LHDLNVQVDWRNHGSTYWVCFV------------HIELVE--- 2699
            |:..|.    :|:..|      .|...|: ..|..||...:.|.            ||..|.   
Zfish  1057 IQVSDQ----LVEINGDSAAGMTHSQAVE-QIRTGGSRIHLVFKRGNGYVPDYDRDHITAVSSSP 1116

  Fly  2700 -------AAQTHHQPRPPPIAVGARVRLRTSSLR 2726
                   ||.:||:|:          |..||||:
Zfish  1117 QPLQSNLAAVSHHRPQ----------RDATSSLQ 1140

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184 11/63 (17%)
UBA_HERC2 2515..2559 CDD:270585 8/43 (19%)
Cul7 2624..2699 CDD:288381 20/94 (21%)
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
LOC556872XP_021334149.1 PDZ_signaling 24..88 CDD:238492
NK 111..>190 CDD:327404 18/88 (20%)
PDZ_signaling 365..440 CDD:238492 16/79 (20%)
PDZ 722..791 CDD:238080 11/71 (15%)
PDZ_signaling 893..980 CDD:238492 21/104 (20%)
PDZ_signaling 1017..1093 CDD:238492 18/88 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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