DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and rcbtb1

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001017352.2	Gene:	rcbtb1 / 550106	XenbaseID:	XB-GENE-987316	Length:	599	Species:	Xenopus tropicalis

Alignment Length:	309	Identity:	99/309 - (32%)
Similarity:	148/309 - (47%)	Gaps:	20/309 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly  3062 PHQLPVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKK 3126
            |..|..:||..:    ..|....|:..|.:.:||.:|......||.|:..:...||.::.|..|:
Frog    84 PQDLASIRQACI----FGSAANEAIYTTQNNEVFVFGMNSSNCLGTGDNQSTIIPRRLDVLCGKR 144

  Fly  3127 IRDVACGSS-HSAAISSQGELYTWGLGEYGRLGHGDNTTQLKP-KLVTALAGRRVVQVACGSRDA 3189
            |.|::.||. |....:..||:|:||...|.:||:|:....:.| ::...|..::|:||||||.
Frog   145 IVDLSYGSGPHILVCNEDGEVYSWGHNGYSQLGNGNAIQGVAPVQVCMELLAKKVIQVACGSH-- 207

  Fly  3190 QTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIE-RLSGIGVVQIECGAQFSLALTRAGEVW 3253
            .::|||.||.||.||..:.|::|.|.:.....|..:. .|....||.|..|...|:|:|..|.|:
Frog   208 HSMALTSDGEVFCWGYNNCGQVGSGTTANQSVPRRVSATLQSKVVVSIAAGQSSSMAVTDNGHVY 272

  Fly  3254 TWGKGDYYRLGHGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSG 3318
            .||.....:||.|...:...|..:.......:|.|.:|..|.||::|.|.:||||.|.|||.|.|
Frog   273 CWGYNGTGQLGIGNTGNQLMPCRLVFAHPVCIIQVVLGYAHTLALSDQGVLYAWGANSHGQLGIG 337

  Fly  3319 NTFVNKKPALVIGLDAVFVNRVACGSSHSIA----------WGLPNASS 3357
            |. .|:...:.:|.:...|...||.|::..|          |||....|
Frog   338 NK-SNQTAPVKVGTNERMVEVTACHSTNISAAKSQSGQVYMWGLCRGQS 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826	6/25 (24%)
		RCC1	3091..3140	CDD:278826	15/49 (31%)
		RCC1	3144..3194	CDD:278826	18/50 (36%)
		RCC1	3197..3246	CDD:278826	16/49 (33%)
		RCC1	3250..3298	CDD:278826	13/47 (28%)
		RCC1	3302..3350	CDD:278826	19/57 (33%)
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
rcbtb1	NP_001017352.2	RCC1	111..153	CDD:278826	13/41 (32%)
		RCC1	162..212	CDD:278826	18/51 (35%)
		RCC1	215..265	CDD:278826	16/49 (33%)
		RCC1	268..317	CDD:278826	13/48 (27%)
		RCC1_2	304..333	CDD:290274	14/28 (50%)
		RCC1	321..362	CDD:278826	17/41 (41%)
		BTB	428..532	CDD:279045
		BTB	439..535	CDD:197585
		SPOP_C_like	535..591	CDD:269810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010