DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and rcc1

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001016101.1 Gene:rcc1 / 548855 XenbaseID:XB-GENE-979094 Length:420 Species:Xenopus tropicalis


Alignment Length:397 Identity:107/397 - (26%)
Similarity:176/397 - (44%) Gaps:69/397 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly  2952 SEYSAGVGPGSTAGAG-----------------AVSTSHEE--AAAAPEQDLPC-----TVMVWG 2992
            |.|....|...|.|.|                 |:.|..|:  .|||......|     ::..:|
 Frog    30 SSYGTVGGQVLTLGQGDVGQLGLGEDVMERKKPALVTLPEDIVQAAAGGMHTVCLGASGSIYTFG 94

  Fly  2993 LNDKEQLG---GLKGSKVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACG--EGTNGRLG 3052
            .||:..||   ..:||:.: |.....:.::  :.::.|......:::||:|:..|  ...||.:|
 Frog    95 CNDEGALGRDTSEEGSETQ-PGKVDLVEKV--VQVSAGDSHTAALTEDGRVFVFGSFRDNNGVIG 156

  Fly  3053 LGVTHNVPLPHQL-PVLRQYVVKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLG--------HG 3108
            |    ..|:...: ||..|.....:.:.||..|.:.||:||.:::.|.||.|:||        .|
 Frog   157 L----LEPMKKSMVPVQMQINAPVIKIASGNDHLVLLTVDGDLYTSGCGEQGQLGRVPERFTNRG 217

  Fly  3109 NRTTLDK---PRLVEALRAK-----KIRDVACGSSHSAAISSQGELYTWGLGEYGRLGHGDNTTQ 3165
            .|..|::   |:.:. |:||     ..:||.||:..:.|:|.:|.:|.:||..|.:|  |..|||
 Frog   218 GRKGLERLLVPQCIH-LKAKGSGRVHFQDVFCGAYFTFAVSQEGHVYGFGLSNYHQL--GTKTTQ 279

  Fly  3166 --LKPKLVTALAGRRVVQVACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTPHEIERL 3228
              ..|:.:|:........|........|:.:..:|.|:|.|..::|:||.|     :...|:...
 Frog   280 SCFAPQNLTSFKNSTKSWVGFSGGQHHTICVDSEGKVYSLGRAEYGRLGLG-----ENAEELSEP 339

  Fly  3229 SGIGVV----QIECGAQFSLALTRAGEVWTWGKGDYYRLGHGGDQHVRKPQPIGG--LRGRRVIH 3287
            :.|.::    .:.|||..|.|::..|.|:.||.|...:||.|.::.|..||.:.|  |..|.|:.
 Frog   340 TPIPILPKTKSVACGASVSYAVSNDGRVFAWGMGTNLQLGTGEEEDVWSPQEMTGKQLEDRDVLS 404

  Fly  3288 VAVGALH 3294
            |:.|..|
 Frog   405 VSSGGQH 411

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826 15/53 (28%)
RCC1 3091..3140 CDD:278826 19/64 (30%)
RCC1 3144..3194 CDD:278826 14/51 (27%)
RCC1 3197..3246 CDD:278826 14/52 (27%)
RCC1 3250..3298 CDD:278826 18/47 (38%)
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
rcc1NP_001016101.1 ATS1 21..418 CDD:227511 107/397 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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