DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and PLEKHA5

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001243399.1	Gene:	PLEKHA5 / 54477	HGNCID:	30036	Length:	1282	Species:	Homo sapiens

Alignment Length:	1068	Identity:	204/1068 - (19%)
Similarity:	331/1068 - (30%)	Gaps:	335/1068 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   806 LVERSVQGCSVPRLVSSLQHKRIVDVAVSVAHCLALSSSGEVFGWGRNDSQQICPASVSSEPL-- 868
            |::..:|.....:.:|.::.|:.::              .|.:|: :.|.|        ..||
Human   305 LIKPEIQNNQKNKEMSKIEEKKALE--------------AEKYGF-QKDGQ--------DRPLTK 346

  Fly   869 LRTPILVSLPTFPASGIACTSAQSL----VWTQSSHQGV-------------PRRAPFVVDLGEP 916
            :.:..|.|||:...||.|| .||::    :...||...:             |...|...:....
Human   347 INSVKLNSLPSEYESGSAC-PAQTVHYRPINLSSSENKIVNVSLADLRGGNRPNTGPLYTEADRV 410

  Fly   917 TFRL--LDQLLGMCSSQDNRQTPNQESECIAVACL--NL--FRLQLLALIANGVEPRQVGLASGS 975
            ..|.  :.||......|..|....:....|:...|  |:  .|.|::|....|.........:..
Human   411 IQRTNSMQQLEQWIKIQKGRGHEEETRGVISYQTLPRNMPSHRAQIMARYPEGYRTLPRNSKTRP 475

  Fly   976 RLLCSL--KTRILGLAGGSQVLRTIQVAAQQALQDG--WSV-------------LLPTAAERAQT 1023
            ..:||:  .|....|..|::..|       ::::|.  |.:             .||    |..|
Human   476 ESICSVTPSTHDKTLGPGAEEKR-------RSMRDDTMWQLYEWQQRQFYNKQSTLP----RHST 529

  Fly  1024 LTS-------------LLPSEPGQASSAGHRFMTDLLVSSLMAEGGLESALQHAIRLESSS---- 1071
            |:|             .:|:.|...|.|.::..:.                |...|.|.||
Human   530 LSSPKTMVNISDQTMHSIPTSPSHGSIAAYQGYSP----------------QRTYRSEVSSPIQR 578

  Fly  1072 --CSADCGDGVHLPLLQLITRLLSNNAALSQTRLSPTLGKQQEKEEEE--------REQQHQEPS 1126
              .:.|.....|.|....:....|..|.|:...:||.  ..|.|..||        |.||.:..|
Human   579 GDVTIDRRHRAHHPKHVYVPDRRSVPAGLTLQSVSPQ--SLQGKTPEELTLLLIKLRRQQAELSS 641

  Fly  1127 T----------------SPSLSLL-HRFQRLLLSHIHQAQPEEETTGAEALLLQYMHALIPACVA 1174
            .                ||...:| |..||..:...||.:..|.       ::..:|.:|.....
Human   642 IREHTLAQLMQLKLEAHSPKNEILSHHLQRNTIYLDHQMKENEP-------IITMVHTMIENSAL 699

  Fly  1175 T-------LQKAHELALQCREPGENSFGQMVGHLGRVLQADISDALLNELLVGLLLLKRDRPQCL 1232
            .       |::..:::|.|....|   |:...:..|..:.|| ||.|:.|.        ::.:.:
Human   700 RPQLYQQFLRQKSKISLYCLSQDE---GRGTLYKYRPEEVDI-DAKLSRLC--------EQDKVV 752

  Fly  1233 GGLRWARLFLPLLRVLDRLNRALGEGELRDGDDMGWPGIICRGGPKGGPPPADPETHYVRRADME 1297
            ..|.      ..|:.|.:....|.:..|....::          ......||..:|..::|.|::
Human   753 HALE------EKLQQLHKEKYTLEQALLSASQEI----------EMHADNPAAIQTVVLQRDDLQ 801

  Fly  1298 NLLLDGSRCIILAGYVCDLSGYNCESETLRSVLDSGLGKDLTAEMSSQVHRTAMEHILEH----- 1357
            |.||...|         :||....|.|......|. |..|:|      |.|..|:..|:|
Human   802 NGLLSTCR---------ELSRATAELERAWREYDK-LEYDVT------VTRNQMQEQLDHLGEVQ 850

  Fly  1358 ----------------------HKLGKYMVQAST-------------------EEKSSAPGP--S 1379
                                  ..|.|:..|..|                   ||:...|.|  .
Human   851 TESAGIQRAQIQKELWRIQDVMEGLSKHKQQRGTTEIGMIGSKPFSTVKYKNEEEEVVPPRPPLP 915

  Fly  1380 RLTHFSSE-CALAQLLGLVANLMC--SGPALQPAELQCRQLD---KSSLLSGGLQLLQPSNP--- 1435
            |...|:.: ..:..|....::|:|  .||...|.|.:..|:.   ::....|....|..|.|
Human   916 RSYDFTEQPPIIPPLPSDSSSLLCYSRGPVHLPEEKKMYQVQGYPRNGSHCGPDYRLYKSEPELT 980

  Fly  1436 ----FDEEKGEARSS----------HSCHSTAGNTPTELPPPLPMQQQLAP----GRGKSQLQLR 1482
                .||..||.:|.          ...|...|..|.....|.|....:|.    .:.|..:.||
Human   981 TVAEVDESNGEEKSEPVSEIETSVVKGSHFPVGVVPPRAKSPTPESSTIASYVTLRKTKKMMDLR 1045

  Fly  1483 ADAFISGLAEARVSEPPVAAWLALTERYCKAHNLMWHQEFATEHPVQELERLLSAVLIRHQYLGG 1547
                         :|.|.:|    .|:.|.|.:.  ......|..::.:.|...|.| |.:..|
Human  1046 -------------TERPRSA----VEQLCLAEST--RPRMTVEEQMERIRRHQQACL-REKKKG- 1089

  Fly  1548 LVLNALETEVPPPRQLGEIIRLVHQAKWSVVRTRQQLNRSYKEVCAPILERLRFLLYEVRP---- 1608
              ||.:......|.|....:|      .:..||.|...|..||:...|.|.      :|:|
Human  1090 --LNVIGASDQSPLQSPSNLR------DNPFRTTQTRRRDDKELDTAIREN------DVKPDHET 1140

  Fly  1609 ---------AISPQ----QRGLRRLP------ILQRPPRFKMLVRRLLQELRSSRQPA----KPE 1650
                     ...||    .:.|::..      :.:..|.....|..:.:|....:.|.    .|:
Human  1141 PATEIVQLKETEPQNVDFSKELKKTENISYEMLFEPEPNGVNSVEMMDKERNKDKMPEDVTFSPQ 1205

  Fly  1651 DLLNASIQQEQEKKPQSMPKQELEEQEE 1678
            |....: ..:.|:.|:...|..::||||
Human  1206 DETQTA-NHKPEEHPEENTKNSVDEQEE 1232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826	4/34 (12%)
		RCC1_2	828..857	CDD:290274	3/28 (11%)
		Cyt-b5	1290..1363	CDD:278597	20/99 (20%)
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
PLEKHA5	NP_001243399.1	WW	12..41	CDD:278809
		WW	58..87	CDD:278809
		PH_PEPP1_2_3	164..267	CDD:270068
		PH	170..266	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900