DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and Wwc2

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_598552.2 Gene:Wwc2 / 52357 MGIID:1261872 Length:1187 Species:Mus musculus


Alignment Length:1312 Identity:252/1312 - (19%)
Similarity:434/1312 - (33%) Gaps:402/1312 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1475 GKSQLQLRADAFISGLAEARVSEPPV---------AAWLALTERY--------CKAHNLMWHQEF 1522
            |..||.|.     .|..|||..:..|         .:|:...:|.        |....|.|..|.
Mouse     6 GSGQLPLP-----RGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEA 65

  Fly  1523 ATEHPVQELERLLSAVLIRHQYLGGLVLNALETEVPPPRQLGEIIRLVHQAKWSVVRTRQQLNRS 1587
            .       .:..:.|..|.|       :|. .|::..||:           :|.  ..::::.:.
Mouse    66 G-------FDPQIGAYYIDH-------INK-TTQIEDPRK-----------QWR--GEQEKMLKD 102

  Fly  1588 YKEVCAPILERLRFLLYEVRPAISPQQR---GLRRLPILQRPPRFKMLVRRLLQELRSSRQPAKP 1649
            |..|....| |.:..||.|:     :||   .|.....|....:.|......|....||.....|
Mouse   103 YLSVAQDAL-RTQKELYHVK-----EQRLALALDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDP 161

  Fly  1650 EDLLNASIQQEQ-----EKKPQSMPKQELEEQEEEETLLRRLNERQIHGEG--ELDPALMQDIVD 1707
             |:|.|.|...|     .|:..|..||||..:::....|::::|:...|:.  ||:.|  :.|: 
Mouse   162 -DILKAEISTTQLRVKKLKRELSHMKQELLYKQQGFETLQQIDEKMSGGQSGYELNEA--KAIL- 222

  Fly  1708 FALQDSCDVETARRAMYCQMQRYQLRLAGLQIVQQLLELHGLLDAAQYSLLNGFLGLHL---KST 1769
                  .::::.|:|:....:..|..:..|..:|:...|...:.:::..|.:..:..||   :.|
Mouse   223 ------TELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNMGSSEPDLRSSPVNSHLSLSRQT 281

  Fly  1770 SSGGGSTGSGSSLHVLGQLNMIS------AYQKARLLLAQSRV----LD---W------------ 1809
            ...|..|.....:.|..:.|:..      .|::|:..:|..::    ||   |            
Mouse   282 LDAGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDGEAWPGALDIEKEKLM 346

  Fly  1810 --------------------AVRELRRLVNQEQQGH-------ARGKDSTNLGTYV--------L 1839
                                :..||.||..:.|  |       |||..|..|...:        |
Mouse   347 LINEKEELLKELQFITPQKRSQEELERLEAERQ--HLEEELMAARGSPSRALTERLKLEEKRKEL 409

  Fly  1840 LKRLPRARFLLSVFGLLAKELGPNELGFLINSGLLGTVLGLLAQTGGEGATGGQVHGELSILYED 1904
            |::|.....|.:......:.|..:.|     |...|:.||.||.:.|...|..:  |.|:.| ..
Mouse   410 LQKLEETTKLTTSLYSQLQSLSSSTL-----SMSSGSSLGSLASSRGSLNTSSR--GSLNSL-SS 466

  Fly  1905 SVLKQKSSKAQLSGPDLAKLMKIGTRIVRGADWKWGDQDGNPPG-------EGRII---SEVGED 1959
            |.|...|...|:......||           |:...::.|..|.       |..::   |:.|:.
Mouse   467 SELYYSSQGDQMDTDYQYKL-----------DFLLQEKGGYIPSGPITTIHENEVVKSPSQPGQS 520

  Fly  1960 GWVRVEWYTGATNSYRMGKEGQYDLQLADSALNVAS------------PTEPEREDV----SGSE 2008
            |...|    |.|.|       .:...|.:::.:|||            |..|...|.    |..:
Mouse   521 GLCGV----GVTAS-------SHTTPLTEASKSVASLSSRSSLSSLSPPGSPLVLDSVFPGSSHD 574

  Fly  2009 ASP---TSDSHPSKLLRHCAAKLLQILAVGTGLHGAQLDKDALRGMTSMFRTIIYPKPSMSNISY 2070
            .||   .:|....:|.|..|       .||.|.:.|.||.|:  |..|        :|.:.:   
Mouse   575 TSPHQFPTDFEDCELSRRFA-------DVGLGENQALLDSDS--GGAS--------QPLLED--- 619

  Fly  2071 ALGWLNLGFIRAISGDCP--RLC-----LELSTPGWLSHYL----------SLLEQPAGNEAGVY 2118
                      :.:| |||  .||     :|.|.|.....:|          :..::....::|||
Mouse   620 ----------KGLS-DCPGELLCEGATDVEKSLPKRRGLHLRGDKTTRVSAAASDESVAGDSGVY 673

  Fly  2119 RQLHCLRLLQLILAQWGAEEEPRMPALVHQLFATLGRIALHCPGDASLLPTAEGKARVLLTASHS 2183
                     :..:.|.|..|:  :|               :...|.:::.||:  .::.|.....
Mouse   674 ---------EASMKQPGEMED--VP---------------YSEEDVTIVETAQ--VQIGLRYDTK 710

  Fly  2184 GSVAEELVALLRRLH--TLPSWNPVINSFLAQKLCVAAELLAEQSHSTALDSEQVFVLGVLGAMG 2246
            .|....::|.||.||  ::|.         :.|:.....||...:..:.|...:|          
Mouse   711 SSSFMVIIAQLRNLHAFSIPH---------SSKVYFRVALLPSSADVSCLFRTKV---------- 756

  Fly  2247 GHDLRPRVGLHCFHEGSHMVIASFTPKGRCLLAPGGVGSGVGFVKVQLPAVMPH-----LDHTVF 2306
                .|......:::...:.::....:.:.|             :|.|.:...|     |..|..
Mouse   757 ----HPPTESVLYNDVFRVAVSQAALQQKTL-------------RVDLCSASKHRREECLAGTQI 804

  Fly  2307 SLSRLPMNEMLLNAWTVLLYGPAPELRELP--SSADGRLDLALLRAQQLQMAVLHTNGVLYRHQV 2369
            ||:.||.:..:...|..||  |:   :::|  .:.||..:.. .|:||..:..:..:.|      
Mouse   805 SLADLPFSNEIFMLWYNLL--PS---KQMPCKKNEDGNEEPG-ARSQQPMLDPIDLDAV------ 857

  Fly  2370 ALRRILKQRAPGSIYASPDEPDRSDAESQQPGEQDQQLSSGSGQEPQLLIQCI-LLRATQASPVK 2433
               ..|..|....:.|...|..:.:.|.:...|:     .|.|::      |: :||.....|..
Mouse   858 ---SALLARTSAELLAVEQELAQEEEEEELRPER-----RGPGRD------CLTMLREASDEPAA 908

  Fly  2434 ACYSYMDLATAALNCIQS--------LATQAHQELSEGGGVPPNGRALSSPPQPTMVHGVPVYNV 2490
            ...|.:.||..: .|.:.        ..:|..:|.:|..|..|:|       .||:|.       
Mouse   909 LRESGVPLAEGS-RCTEDPKPCPRGPETSQCRKEPAEDPGQLPSG-------LPTLVD------- 958

  Fly  2491 ARKEQKPSEQVEQKSKWPAAATDAQLIGQIMEMGFTRRTVELALKQLSLQAEIMPTPEQIVQWI- 2554
              ||....|.|:  |.......|...:.. .:..|.|.:|.:..:..|        |.:..|:| 
Mouse   959 --KETNTDEVVD--SNMAVRPKDRSSLSS-RQHPFVRNSVIVRSQTFS--------PGERSQYIC 1010

  Fly  2555 -LEHPDVCANTIEEDTLPLASSASSHDPEAD----------SDNECPSSNS------TTSSSTSS 2602
             |...|..::|:.:.:|.:.:|.........          :..|||...|      ..:|.|..
Mouse  1011 RLNRSDSDSSTLAKKSLFVRNSTERRSLRVKRAVCQPTLRRTAQECPVRTSLDLELDLQASLTRQ 1075

  Fly  2603 DTVEGQPMAVSG 2614
            ..:..:..|:.|
Mouse  1076 SRLNDELQALRG 1087

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184 11/68 (16%)
UBA_HERC2 2515..2559 CDD:270585 8/45 (18%)
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
Wwc2NP_598552.2 WW 12..41 CDD:278809 7/33 (21%)
WW 59..88 CDD:278809 8/43 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 438..464 9/27 (33%)
C2_Kibra 699..822 CDD:176062 26/160 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 830..849 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 874..963 24/116 (21%)
Phage_Nu1 <1088..>1146 CDD:294991 252/1312 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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