DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and Magi2

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	XP_006535806.1	Gene:	Magi2 / 50791	MGIID:	1354953	Length:	1414	Species:	Mus musculus

Alignment Length:	1298	Identity:	247/1298 - (19%)
Similarity:	374/1298 - (28%)	Gaps:	514/1298 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly  2298 MPHLDHTVFSLSRLPMNEMLLNAWTVLLYGPAPELRELPSSADGRLDLALLRAQQLQMAVLHTNG 2362
            |||.:     |...|:.              ||..||.|        |....|.||:...|.|.
Mouse   391 MPHTE-----LGAKPLQ--------------APGFREKP--------LFTRDASQLKGTFLSTT- 427

  Fly  2363 VLYRHQVALRRILKQRAPGSIYA--SPDEPDR----SDAESQQPGEQDQQLSSGSGQEPQLLI-- 2419
                        ||:...|..:.  ..||||.    .......|..||.::.:|     .:::
Mouse   428 ------------LKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETG-----DVIVYI 475

  Fly  2420 -QCILLRATQASPVKACYSYMDLATAALNCIQSLATQAHQELSEGGGVPPNGRALSSPPQPTMVH 2483
             :..:|..|.|..||...|.....:..|...:........|......|||  .|:...|.|.||:
Mouse   476 NEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPP--LAIMERPPPVMVN 538

  Fly  2484 GVPVYN-----VARKEQKPSEQVEQK----SKWPAAATDAQLIGQI--------MEMGFTRRTVE 2531
            |...|.     ::|..|...:..::.    ...||   |.||.|..        :.|..:..|
Mouse   539 GRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPA---DGQLDGTYPPPVHDDNVSMASSGAT-- 598

  Fly  2532 LALKQLSLQAEIM------------------PTPEQIVQWILEHPDV--CANTIEEDTLPLASSA 2576
                    |||:|                  ||.:::.|.:    |:  |....|.|.:...:..
Mouse   599 --------QAELMTLTIVKGAQGFGFTIADSPTGQRVKQIL----DIQGCPGLCEGDLIVEINQQ 651

  Fly  2577 S----SHDPEADSDNECPSSNSTT-------------SSSTSSDTVE--GQPM-AVSGPA----- 2616
            :    ||....|...:||..:.|:             :.....|..|  |.|. ::|.||
Mouse   652 NVQNLSHTEVVDILKDCPVGSETSLIIHRGGFFSPWKTPKPMMDRWENQGSPQTSLSAPAVPQNL 716

  Fly  2617 --PPV-----------KFESRKDFQTADLYALY--------VRGLVRPGMTVRCCR---DFEE-- 2655
              ||.           .|:.||    .|.|.||        .|..|.|..:.|...   |::|
Mouse   717 PFPPALHRSSFPDSTEAFDPRK----PDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELD 777

  Fly  2656 -------------IKQGD-------MGTVLIV---DTEG-LH--DLNVQVD-----WRNHGSTYW 2689
                         |..||       :|.|:.:   |.:| ||  |..|.||     .:.|...
Mouse   778 VHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYV-- 840

  Fly  2690 VCFVHIELVEAAQTHHQPRPPPIAVGARVRLRTSSLRYGMLCPLRLGRSQGSSAIGVVSSVRSKQ 2754
                 |:|:     ||..|...:    .:.:|...|..|..|| ..|||.||.:.. .||.||..
Mouse   841 -----IDLM-----HHAARNGQV----NLTVRRKVLCGGEPCP-ENGRSPGSVSTH-HSSPRSDY 889

  Fly  2755 LTVDFPDQPAWQGHINEVELVASQPTSATLPSLGDSCSQMPPSDLIEDWSRCIRSLTVSSNEAAA 2819
            .|....:..|              |:|...|..|.:...:..||::         :....||...
Mouse   890 ATYSNSNHAA--------------PSSNASPPEGFASHSLQTSDVV---------IHRKENEGFG 931

  Fly  2820 KHLLNGSNQPWQSCS------------SGPCRHWIRLELHDRILVHSLTLKVSPEDHSHMPSLLE 2872
            ..:::..|:|....:            ..|.....:|::.||||.      |:.:...:||.
Mouse   932 FVIISSLNRPESGATITVPHKIGRIIDGSPADRCAKLKVGDRILA------VNGQSIINMPH--- 987

  Fly  2873 IRVGDCVDSLKEYTWIPVPAGAS---RVLLMQQV--PTYYPWVEVVVKQCQNNGIQCKIHGIKFV 2932
               .|.|..:|:       ||.|   |::..:::  ||..|..|
Mouse   988 ---ADIVKLIKD-------AGLSVTLRIIPQEELNSPTSAPSSE--------------------- 1021

  Fly  2933 GRRQQPDLQHILANAQFLASEYSAGVGPGSTAGAGAVSTSHEEAAAAPEQDLPCTVMVWGLNDKE 2997
              :|.|           :|.::|........|.....:.:...|..||.|.|
Mouse  1022 --KQSP-----------MAQQHSPLAQQSPLAQPSPATPNSPVAQPAPPQPL------------- 1060

  Fly  2998 QLGGLKGS-------------KVKVPTFSQTISRLRPIHIAGGSKSLFIVSQDGKVYACGEGTNG 3049
            ||.|.:.|             .::.|.|  |..|..|:                         :.
Mouse  1061 QLQGHENSYRSEVKARQDVKPDIRQPPF--TDYRQPPL-------------------------DY 1098

  Fly  3050 RLGLGVTHNVPLP----HQLPVLRQYVVK-----------KVAVHSGGKHALALTLDGKVFSWGE 3099
            |...|..::.|.|    ...|..|||.:.           .|.:..|.|        |..||...
Mouse  1099 RQPPGGDYSQPPPLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAK--------GFGFSIRG 1155

  Fly  3100 GEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSSHSAAISSQGELYTWGLGE------YGRLG 3158
            |.:.|:                                       :||...|.|      .||:.
Mouse  1156 GREYKM---------------------------------------DLYVLRLAEDGPAIRNGRMR 1181

  Fly  3159 HGDNTTQLKPKLVTALAGRRVVQ-VACGSRDAQTLALTEDGAVFSWGDGDFGKLGRGGSEGSDTP 3222
            .||...::..:....:...|.:: :..|.|..:.|.                |.|.|.....|.|
Mouse  1182 VGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLL----------------KRGTGQVPEYDEP 1230

  Fly  3223 HEIERLSGIGVVQIECGAQFSLALT---------------RAGEVWTWGKGDYYRLGHGGDQHVR 3272
            |.....:.......|.|......|:               :.|...||   |..|     :..||
Mouse  1231 HAWSAAAAAAPGLPEVGVSLEDILSPFSPSHPAPPSDPSHQIGPDPTW---DIQR-----EHDVR 1287

  Fly  3273 KPQPI--GGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALVIGLDAV 3335
            ||:.:  ||.:.:|:                      |:.   ::.|.:...:.:|.|
Mouse  1288 KPKELSAGGQKKQRL----------------------GEQ---RERSASPQRSARPRL------- 1320

  Fly  3336 FVNRVACGSSHSIAWGLPNAS--SDEEKRGPVPFSSTRDPLGGSSLGIYEAETMQTLKQEAKP 3396
              ..|..|.      |.|.|.  :.|...|.......|:.||.:  |..|||....::..|:|
Mouse  1321 --EEVPGGQ------GRPEAGRPASEAADGKEALRGRREGLGAA--GAREAEAKVGVRSGARP 1373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585	12/69 (17%)
		Cul7	2624..2699	CDD:288381	28/118 (24%)
		APC10-HERC2	2762..2932	CDD:176485	31/186 (17%)
		RCC1	3037..3088	CDD:278826	11/65 (17%)
		RCC1	3091..3140	CDD:278826	5/48 (10%)
		RCC1	3144..3194	CDD:278826	12/56 (21%)
		RCC1	3197..3246	CDD:278826	8/48 (17%)
		RCC1	3250..3298	CDD:278826	12/49 (24%)
		RCC1	3302..3350	CDD:278826	6/47 (13%)
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
Magi2	XP_006535806.1	PDZ_signaling	22..96	CDD:238492
		NK	118..290	CDD:388413
		WW	303..332	CDD:366073
		WW	349..378	CDD:366073
		PDZ	427..508	CDD:214570	18/98 (18%)
		PDZ	601..682	CDD:214570	15/84 (18%)
		MAGI_u5	681..755	CDD:374709	16/77 (21%)
		PDZ	774..860	CDD:214570	21/101 (21%)
		PDZ_signaling	919..1006	CDD:238492	21/114 (18%)
		PDZ_signaling	1138..1218	CDD:238492	20/142 (14%)
		MAGI_u1	1245..1285	CDD:374706	8/47 (17%)
		PHA03307	<1255..>1407	CDD:223039	32/169 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900