DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment HERC2 and Wwc2

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001102581.1 Gene:Wwc2 / 498630 RGDID:1559427 Length:1194 Species:Rattus norvegicus


Alignment Length:1380 Identity:258/1380 - (18%)
Similarity:432/1380 - (31%) Gaps:480/1380 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly  1475 GKSQLQLRADAFISGLAEARVSEPPV---------AAWLALTERY--------CKAHNLMWHQEF 1522
            |..||.|.     .|..|||..:..|         .:|:...:|.        |....|.|..|.
  Rat     6 GSGQLPLP-----RGWEEARDYDGKVFYIDHNTRRTSWIDPRDRLTKPLSFADCVGDELPWGWEA 65

  Fly  1523 ATEHPVQELERLLSAVLIRHQYLGGLVLNALETEVPPPRQLGEIIRLVHQAKWSVVRTRQQLNRS 1587
            .       .:..:.|..|.|       :|. .|::..||:           :|.  ..::::.:.
  Rat    66 G-------FDPQIGAYYIDH-------INK-TTQIEDPRK-----------QWR--GEQEKMLKD 102

  Fly  1588 YKEVCAPILERLRFLLYEVRPAISPQQR---GLRRLPILQRPPRFKMLVRRLLQELRSSRQPAKP 1649
            |..|....| |.:..||.|:     :||   .|.....|....:.|......|....||.....|
  Rat   103 YLSVAQDAL-RTQKELYHVK-----EQRLALALDEYVRLNDAYKEKSSSHTSLFSGSSSSTKYDP 161

  Fly  1650 EDLLNASI-----QQEQEKKPQSMPKQELEEQEEEETLLRRLNERQIHGEGELDPALMQDIVDFA 1709
             |:|.|.|     :.::.|:..|..||||..:::....|::::|:...|:...:.:..:.|:   
  Rat   162 -DILKAEISTTRLRVKKLKRELSQMKQELLYKQQGFETLQQIDEKMSGGQSGYELSEAKAIL--- 222

  Fly  1710 LQDSCDVETARRAMYCQMQRYQLRLAGLQIVQQLLELHGLLDAAQYSL----LNGFLGLHLKSTS 1770
                .::::.|:|:....:..|..:..|..:|:...|...:.:::..|    :|..|.|..::..
  Rat   223 ----TELKSIRKAISSGEKEKQDLMQSLAKLQERFHLDQNMGSSEPDLRCSPVNSHLSLSRQTLD 283

  Fly  1771 SG-----GGSTGSGSSLHVLGQLNMISAYQKARLLLAQSRV----LD---W-----AVRELRRLV 1818
            :|     .|..|..|..::..::.:...|::|:..:|..::    ||   |     ..:|...|:
  Rat   284 AGSQTSISGDIGVRSRSNLAEKVRLSLQYEEAKRSMANLKIELSKLDGEAWPGALDVEKEKLMLI 348

  Fly  1819 N--------------------------------QEQQGHARG----------------------- 1828
            |                                :|:...|||                       
  Rat   349 NEKEELLKELQFITPQKRTQDELERLEAERQRLEEELVAARGLPSRALAERLKLEEKRKELLQKL 413

  Fly  1829 KDSTNLGTYVL--LKRLPRARFLL---SVFGLLAKELGP------NELGFLINSGLLGTVLG--- 1879
            :::|.|.||:.  ||.|..:...:   |..|.||...|.      ..|..|.:|.|..:..|   
  Rat   414 EETTKLTTYLYSQLKSLSSSTLSMSSGSSLGSLASSRGSLNTSSRGSLNSLSSSDLYYSSQGDQM 478

  Fly  1880 ----------LLAQTGGEGATGGQVHGELSILYEDSVLKQKSSKAQLSGPDLAKLMKIGTRIVRG 1934
                      ||.:.||...:     |.::.::|:.|:|..|...| ||     |..:|....  
  Rat   479 DTDYQYKLDFLLQEKGGYIPS-----GPITTIHENEVVKSPSQPGQ-SG-----LCGLGVAAT-- 530

  Fly  1935 ADWKWGDQDGNPPGEGRIISEVGEDGWVRVEWYTGATNSYRMGKEGQYDLQLADSALNVASPTEP 1999
                    ...||                   .|.|:.|..       .|....|..:::.|..|
  Rat   531 --------SHTPP-------------------LTEASKSVT-------SLSSRSSLSSLSPPGSP 561

  Fly  2000 EREDV----SGSEASP---TSDSHPSKLLRHCAAKLLQILAVGTGLHGAQLDKDALRGMTSMFRT 2057
            ...|.    |..:.||   |:|....:|.||.|       .:|.|.:...||.|:          
  Rat   562 LVLDSTFPGSSHDTSPHQFTADLEDCELSRHFA-------DIGLGENQVLLDSDS---------- 609

  Fly  2058 IIYPKPSMS-----NISYALGWLNLGFIRAISGDCPRLCLELSTPGWLSHYL----------SLL 2107
               ..||.|     ::....|    |.:...|.|     :|.|.|.....:|          :..
  Rat   610 ---GGPSQSLLEDKDLDECTG----GLLYEGSAD-----VEKSLPKRRGLHLRGDKTARVSAAAS 662

  Fly  2108 EQPAGNEAGVYRQLHCLRLLQLILAQWGAEEEPRMPALVHQLFATLGRIALHCPGDASLLPTAEG 2172
            ::....::|||.                        |.|.|            ||:...:|..|.
  Rat   663 DESVAGDSGVYE------------------------ASVKQ------------PGEIEDIPYREE 691

  Fly  2173 KARVLLTA-----------SHSGSVAEELVALLRRLH--TLPSWNPVINSFLAQKLCVAAELLAE 2224
            ...::.||           |.|..|   ::|.||.||  ::|                       
  Rat   692 DVTIVETAQVQIGLRYDTKSSSFMV---IIAQLRNLHAFSIP----------------------- 730

  Fly  2225 QSHSTALDSEQVFVLGVLGAMGGHDLRPRVGLH------CFHEGSHMVIASFTPKGRCLLAPGGV 2283
              ||    |:..|.:.||.:........|..:|      .:::...:.|:....:.:.|      
  Rat   731 --HS----SKVYFRVAVLPSSADVSCLFRTKVHPPTESVLYNDVFRVAISQVVLQQKTL------ 783

  Fly  2284 GSGVGFVKVQLPAVMPH-----LDHTVFSLSRLPMNEMLLNAWTVLLYGPAPELRELP------- 2336
                   :|.|.:|...     |..|..||:.||.:..:...|..||  |:   :::|       
  Rat   784 -------RVDLCSVSKRRREECLAGTQISLADLPFSNEIFMLWYNLL--PS---KQIPCKKKEEG 836

  Fly  2337 ------SSADGRLDLALLRAQQLQMAVLHTNGVLYRHQVALRRILKQRAPGSIYASPDEPDRSDA 2395
                  .|....||.|.|.|         .:.:|.|....|..:.::.|        .|.:..:.
  Rat   837 GGQPGAQSPQPALDSADLDA---------VSALLARTSAELLAVEQELA--------QEEEEEEE 884

  Fly  2396 ESQQPGEQDQQLSSGSGQEPQLLIQCI-LLRATQASPVKACYSYMDLATAA------LNCIQSLA 2453
            |..:|..:      |.|::      |: :||...|..|.|..|.:.||...      ..|.:...
  Rat   885 EELRPEHR------GPGED------CLTMLREASAETVAAKESGVHLAEGGHCPEDPSPCTRGPG 937

  Fly  2454 TQAHQELSEGGGVPPNGRALSSPPQPTMVHGVPVYNVARKEQKPSEQVEQKSKWPAAATDAQLIG 2518
            |...|...|.|.....|:..::  .||:|.         ||....|.|:  |.......|...:.
  Rat   938 TSRDQCRKEKGRTEDPGQPATA--VPTLVD---------KETNTDEAVD--SNIAVRPKDRSSLS 989

  Fly  2519 QIMEMGFTRRTVELALKQLSLQAEIMPTPEQIVQWI--LEHPDVCANTIEEDTLPLASSASSHDP 2581
            . ....|.|.:|.:..:..|        |.:..|:|  |...|..::|:.:.:|.:.:|......
  Rat   990 S-QHHPFVRSSVIVRSQTFS--------PGERSQYICRLNRSDSDSSTLAKKSLFVRNSTERRSL 1045

  Fly  2582 EAD----------SDNECPSSNS------TTSSSTSSDTVEGQPMAVSGPAPPVKFESRKDFQTA 2630
            ...          :..|||...|      ..:|.|....:..:..|:.|...  |.|..|.....
  Rat  1046 RVKRAVCQPTLRRTAQECPVRTSLDLELDLQASLTRQSRLNDELQALRGLQQ--KLEELKAQGET 1108

  Fly  2631 DLYALYVRGLVRPGM 2645
            ||         .|||
  Rat  1109 DL---------PPGM 1114

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184 7/58 (12%)
UBA_HERC2 2515..2559 CDD:270585 8/45 (18%)
Cul7 2624..2699 CDD:288381 6/22 (27%)
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274
RCC1 4154..4203 CDD:278826
RCC1 4206..4257 CDD:278826
RCC1 4260..4309 CDD:278826
RCC1 4312..4360 CDD:278826
RCC1 4364..4413 CDD:278826
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
Wwc2NP_001102581.1 WW 12..41 CDD:278809 7/33 (21%)
WW 59..88 CDD:278809 8/43 (19%)
DUF342 <283..385 CDD:302792 14/101 (14%)
YlqD 351..>420 CDD:287979 5/68 (7%)
C2_Kibra 699..822 CDD:176062 30/167 (18%)
Phage_Nu1 <1095..>1153 CDD:294991 8/31 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5021
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.