DRSC/TRiP Functional Genomics Resources

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Protein Alignment HERC2 and rcc1l

DIOPT Version :9

Sequence 1:NP_608388.2 Gene:HERC2 / 33035 FlyBaseID:FBgn0031107 Length:4912 Species:Drosophila melanogaster
Sequence 2:NP_001007510.1 Gene:rcc1l / 493236 XenbaseID:XB-GENE-963910 Length:449 Species:Xenopus tropicalis


Alignment Length:504 Identity:115/504 - (22%)
Similarity:178/504 - (35%) Gaps:157/504 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  4001 LHCHAHQLESTSTLLHEDHTLFQAPHDAQLLQWLNRRPDDWALSWGGASTIYGWGHNHRGQLGGL 4065
            |.|..|.....|..:.:.    :|..:..:.|::..|..       ....::.||.:|.|.||  
 Frog    13 LKCKGHLQRHLSAKVSKS----RAQDELPVFQYVGERAK-------RKKRVFVWGFSHTGALG-- 64

  Fly  4066 EGSRIKTPTPCEALSLLRPVQLAGGEQSLFAVTP-----DGKL--FATGYGSGGRLGVGGSDSWA 4123
                    .|    |.:.| :....:...|.:||     |.|:  .|.|||.             
 Frog    65 --------IP----SFVIP-ETGRKKPKKFQLTPYRLDMDEKISSAACGYGF------------- 103

  Fly  4124 IPTLLGSLQHVFVKKVAVNSGGKHCLALTTEGEVYAWGEG--EDGKLGHGNRMSYDRPKLVEHL- 4185
              |||.|                     .|......||.|  :|.::|. :|...||.|..|:: 
 Frog   104 --TLLSS---------------------KTANITKIWGMGLNKDSQIGF-HRSRRDRTKGYEYIL 144

  Fly  4186 ------------NGMSVADIACGSAHSAAITASGHVLTWGKGRYGRL------GHGDSEDQLRPK 4232
                        ....|..::||.|||..:|....|.:.|...||:.      |...||.||..:
 Frog   145 EPSPIPLPLDKPQETKVLQVSCGRAHSLILTDKEGVFSLGNNSYGQCAREVIEGEIYSESQLIHR 209

  Fly  4233 LVEALLGYRAIDIACGSGDAQTLCITDDDNVWSWGDGDYGKLGRGGSDGCKLPYKI-ESLAGLGV 4296
            :.|  |..|.:.:|||..  .:|..|:...|:|.|.|..|:.|.|..:.|..|.|: ..:||:.:
 Frog   210 VRE--LDSRVVQVACGQD--HSLFRTEKGEVYSCGWGADGQTGLGHFNVCSNPTKLGGDMAGVNI 270

  Fly  4297 VKVECGSQFSVALTKSGAVYTWGKGDFHRLG------------HGSVDHVRRPKKVA-------- 4341
            |:|.......:|:::.|.:|.||..::.:|.            |....||.:.|.||        
 Frog   271 VQVATYGDCCLAVSEEGQLYGWGNSEYLQLACVTDSTQVNVPQHLPFQHVGKVKHVACGGTGCIA 335

  Fly  4342 ------------ALQGK---------------------------KIISIATGSLHCVACSDSGEV 4367
                        .:.||                           ::..:.:|..|..|.::.||:
 Frog   336 VNGDGSVFVWGYGILGKGPNFLEAQQPEIIPQSLFGLSDFNPDIRVTKVFSGLGHFAALNNRGEL 400

  Fly  4368 YTWGDNDEGQLGDGTVTAIQRPRLVAALQGKHIVKVTCGSAHTLALSTS 4416
            :.||.|..|.||.|.......|..| .:.|: :|.|:||..|.:||..|
 Frog   401 FVWGKNLRGCLGTGRFEDQYFPWRV-TVPGE-VVDVSCGVDHMVALVKS 447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HERC2NP_608388.2 RCC1 638..683 CDD:278826
RCC1 687..737 CDD:278826
RCC1 740..787 CDD:278826
RCC1 790..841 CDD:278826
RCC1_2 828..857 CDD:290274
Cyt-b5 1290..1363 CDD:278597
MIB_HERC2 1928..1987 CDD:284184
UBA_HERC2 2515..2559 CDD:270585
Cul7 2624..2699 CDD:288381
APC10-HERC2 2762..2932 CDD:176485
RCC1 3037..3088 CDD:278826
RCC1 3091..3140 CDD:278826
RCC1 3144..3194 CDD:278826
RCC1 3197..3246 CDD:278826
RCC1 3250..3298 CDD:278826
RCC1 3302..3350 CDD:278826
RCC1_2 4136..4166 CDD:290274 4/31 (13%)
RCC1 4154..4203 CDD:278826 16/63 (25%)
RCC1 4206..4257 CDD:278826 16/56 (29%)
RCC1 4260..4309 CDD:278826 14/49 (29%)
RCC1 4312..4360 CDD:278826 15/106 (14%)
RCC1 4364..4413 CDD:278826 17/48 (35%)
HECTc 4509..4880 CDD:238033
HECTc 4553..4878 CDD:214523
rcc1lNP_001007510.1 RCC1 <51..374 CDD:332518 85/378 (22%)
RCC1_2 381..410 CDD:316098 8/28 (29%)
RCC1 398..444 CDD:306840 17/47 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1062377at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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