DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HERC2 and NEDD4

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001271267.1	Gene:	NEDD4 / 4734	HGNCID:	7727	Length:	1319	Species:	Homo sapiens

Alignment Length:	637	Identity:	151/637 - (23%)
Similarity:	253/637 - (39%)	Gaps:	151/637 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  4310 TKSGAVYTWGKGDFHRLGHGSVDHVRR------PKKVAALQGKKIIS--IATGSLHCVACSDSGE 4366
            |.||....|.:....|.....|||..|      |...|.::..::.|  .:.|.....:.||||:
Human   765 TSSGLPPGWEEKQDERGRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQ 829

  Fly  4367 VYTW-GDNDEGQLGDG------------------TVTAIQRPRL--VAALQGKHIVKVTCGSAHT 4410
            ..|. .:.::|.|..|                  ..|..:.|||  .|.|:||
Human   830 QVTQPSEIEQGFLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGK------------ 882

  Fly  4411 LALSTSQLSERLRPLPNPPLEYDLVRDLAPEALH--ARLILLHH---FSELVCPCLAMLPISGDL 4470
            .:|.|   |..|.||| |..|         |..|  .|:..::|   .::...|.|..:.|:|.
Human   883 TSLDT---SNDLGPLP-PGWE---------ERTHTDGRIFYINHNIKRTQWEDPRLENVAITGP- 933

  Fly  4471 SLGALKDVLVYNIKEAAFRKVIQTTMVRDKQHG-PVIELNRIQVKRSRNRCNGLAGI--DGMKSV 4532
            ::...:|   |..|...||:.::      ||:. |    |:.::|..|      |.:  |..:.:
Human   934 AVPYSRD---YKRKYEFFRRKLK------KQNDIP----NKFEMKLRR------ATVLEDSYRRI 979

  Fly  4533 FGQMVQKLPLLTQEALALPHRVWKVKFVGESVDDCGGGYSESIAEMCDELQN-----------GS 4586
            .|         .:.|..|..|:| ::|.||...|.||...|....:..|:.|           .:
Human   980 MG---------VKRADFLKARLW-IEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDN 1034

  Fly  4587 VPLLINTPNGRGEAGANRDCFLLDPTLSSVLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVWRQL 4651
            ..|.||..:|.    .|.|            .::.|:|:|.:.|:||..|..|......|.::.:
Human  1035 YTLQINPNSGL----CNED------------HLSYFKFIGRVAGMAVYHGKLLDGFFIRPFYKMM 1083

  Fly  4652 TGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFST-----SSARGHEVPLSTRYTHI 4711
            ..:.:...|:..||.:|...|..|  :::||   |.|:|.|..     .....||:........:
Human  1084 LHKPITLHDMESVDSEYYNSLRWI--LENDP---TELDLRFIIDEELFGQTHQHELKNGGSEIVV 1143

  Fly  4712 SPRNRAEYVRLALGFR-LHEFDEQVKAVRDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLK 4775
            :.:|:.||:.|.:.:| ::...:|:.|.::|..::||..|:.:|...||:.::||..|:.:...:
Human  1144 TNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWR 1208

  Fly  4776 SVATYK-GFDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLPRT-IADFRGRDFVLQVLEKN 4838
            ....|| |:..:..::.|||:.:....:::|...|:||.|.:|:|.. .|:..|         .|
Human  1209 EHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYG---------SN 1264

  Fly  4839 PPDHF----------LPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSID 4880
            .|..|          ||.::|||..|.:|.|.....|.:||:.||...:..|
Human  1265 GPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 1316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826
		RCC1	3091..3140	CDD:278826
		RCC1	3144..3194	CDD:278826
		RCC1	3197..3246	CDD:278826
		RCC1	3250..3298	CDD:278826
		RCC1	3302..3350	CDD:278826
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826	12/55 (22%)
		RCC1	4364..4413	CDD:278826	14/69 (20%)
		HECTc	4509..4880	CDD:238033	96/401 (24%)
		HECTc	4553..4878	CDD:214523	88/353 (25%)
NEDD4	NP_001271267.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..229
		C2	<517..570	CDD:417471
		Mediates interaction with TNIK. /evidence=ECO:0000250	578..981		59/260 (23%)
		WW	611..643	CDD:197736
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..780		4/14 (29%)
		WW	769..798	CDD:395320	6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	796..834		9/37 (24%)
		WW	842..871	CDD:395320	3/28 (11%)
		WW	893..925	CDD:197736	10/41 (24%)
		HECTc	986..1315	CDD:214523	89/359 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5021
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900