DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HERC2 and rcbtb2

DIOPT Version :9

Sequence 1:	NP_608388.2	Gene:	HERC2 / 33035	FlyBaseID:	FBgn0031107	Length:	4912	Species:	Drosophila melanogaster
Sequence 2:	NP_001004950.1	Gene:	rcbtb2 / 448359	XenbaseID:	XB-GENE-952598	Length:	526	Species:	Xenopus tropicalis

Alignment Length:	292	Identity:	101/292 - (34%)
Similarity:	148/292 - (50%)	Gaps:	15/292 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly  3073 VKKVAVHSGGKHALALTLDGKVFSWGEGEDGKLGHGNRTTLDKPRLVEALRAKKIRDVACGSS-H 3136
            :::..|...|...|.||.:.:||..|....|.||.|:..::.:||.::.|..|:|..::.||. |
Frog    21 IQQACVFGAGNEVLYLTKNDEVFVMGTNSSGCLGTGDAQSILEPRRIDMLSGKRIVSLSYGSGPH 85

  Fly  3137 SAAISSQGELYTWGLGEYGRLGHGDNTTQLKP-KLVTALAGRRVVQVACGSRDAQTLALTEDGAV 3200
            ...::|.||:|:||...|.:||:|.....|.| ::.|.|..::.:.|||||.  .::.||.||.|
Frog    86 VVIVTSDGEVYSWGHNAYSQLGNGSTNQALSPCQVSTNLINKKAISVACGSH--HSMVLTCDGEV 148

  Fly  3201 FSWGDGDFGKLGRGGSEGSDTPHEIER-LSGIGVVQIECGAQFSLALTRAGEVWTWGKGDYYRLG 3264
            ::||..:.|::|.|.:.....|.::.. |....|:.|.||...|:|:...|||:.||.....:||
Frog   149 YAWGYNNSGQVGSGSTANQPIPRKVTSCLQNKTVIGIACGQMSSMAVVDNGEVYAWGYNGNGQLG 213

  Fly  3265 HGGDQHVRKPQPIGGLRGRRVIHVAVGALHCLAVTDAGQVYAWGDNDHGQQGSGNTFVNKKPALV 3329
            .|...:...|..|..|:|.||..|..|..|.||:||.|.:||||.|.:||.|:||......|..|
Frog   214 LGSSGNQPTPCRIAALQGIRVEQVVCGYAHTLALTDEGVMYAWGANSYGQLGTGNKSNQSYPVQV 278

  Fly  3330 IGLDAVFVNRVACGSSHSIA----------WG 3351
            |......|...||.|||:.|          ||
Frog   279 IVDKERIVEIAACHSSHTSAAKSQSGQVYMWG 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HERC2	NP_608388.2	RCC1	638..683	CDD:278826
		RCC1	687..737	CDD:278826
		RCC1	740..787	CDD:278826
		RCC1	790..841	CDD:278826
		RCC1_2	828..857	CDD:290274
		Cyt-b5	1290..1363	CDD:278597
		MIB_HERC2	1928..1987	CDD:284184
		UBA_HERC2	2515..2559	CDD:270585
		Cul7	2624..2699	CDD:288381
		APC10-HERC2	2762..2932	CDD:176485
		RCC1	3037..3088	CDD:278826	3/14 (21%)
		RCC1	3091..3140	CDD:278826	15/49 (31%)
		RCC1	3144..3194	CDD:278826	18/50 (36%)
		RCC1	3197..3246	CDD:278826	15/49 (31%)
		RCC1	3250..3298	CDD:278826	18/47 (38%)
		RCC1	3302..3350	CDD:278826	21/57 (37%)
		RCC1_2	4136..4166	CDD:290274
		RCC1	4154..4203	CDD:278826
		RCC1	4206..4257	CDD:278826
		RCC1	4260..4309	CDD:278826
		RCC1	4312..4360	CDD:278826
		RCC1	4364..4413	CDD:278826
		HECTc	4509..4880	CDD:238033
		HECTc	4553..4878	CDD:214523
rcbtb2	NP_001004950.1	ATS1	<17..269	CDD:227511	88/249 (35%)
		RCC1	250..298	CDD:366085	20/47 (43%)
		BTB_POZ	349..465	CDD:365784
		BACK_RCBTB2	462..526	CDD:350604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062377at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010